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Showing 1-30 of 319 results for "PHR1009" within Papers
Lianguo Wang et al.
Circulation research, 114(9), 1410-1421 (2014-02-27)
Sarcoplasmic reticulum (SR) Ca(2+) cycling is key to normal excitation-contraction coupling but may also contribute to pathological cardiac alternans and arrhythmia. To measure intra-SR free [Ca(2+)] ([Ca(2+)]SR) changes in intact hearts during alternans and ventricular fibrillation (VF). Simultaneous optical mapping
Georgios Petrides et al.
The American journal of psychiatry, 172(1), 52-58 (2014-08-27)
Up to 70% of patients with treatment-resistant schizophrenia do not respond to clozapine. Pharmacological augmentation to clozapine has been studied with unimpressive results. The authors examined the use of ECT as an augmentation to clozapine for treatment-refractory schizophrenia. In a
Rosario Villegas et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(21), 7179-7189 (2014-05-23)
Axonal degeneration represents an early pathological event in neurodegeneration, constituting an important target for neuroprotection. Regardless of the initial injury, which could be toxic, mechanical, metabolic, or genetic, degeneration of axons shares a common mechanism involving mitochondrial dysfunction and production
Susanne Burdak-Rothkamm et al.
Cancer letters, 356(2 Pt B), 454-461 (2014-10-12)
Radiotherapy is an important treatment option for many human cancers. Current research is investigating the use of molecular targeted drugs in order to improve responses to radiotherapy in various cancers. The cellular response to irradiation is driven by both direct
[How much coffee is healthy?].
Franziska Etter
Praxis, 103(25), 1531-1532 (2014-12-11)
Biomedicine. Human stem cells from cloning, finally.
Gretchen Vogel
Science (New York, N.Y.), 340(6134), 795-795 (2013-05-21)
Fouad F Al-Qaim et al.
Journal of chromatography. A, 1345, 139-153 (2014-04-29)
An analytical method that facilitated the analysis of 11 pharmaceuticals residue (caffeine, prazosin, enalapril, carbamazepine, nifedipine, levonorgestrel, simvastatin, hydrochlorothiazide, gliclazide, diclofenac-Na, and mefenamic acid) with a single pre-treatment protocol was developed. The proposed method included an isolation and concentration procedure
Carolina Paola GarcĆa et al.
Stem cell research, 12(2), 400-414 (2014-01-02)
Embryonic stem cells (ESCs) need to maintain their genomic integrity in response to DNA damage to safeguard the integrity of the organism. DNA double strand breaks (DSBs) are one of the most lethal forms of DNA damage and, if not
Elizabeth C Lowcock et al.
Nutrition and cancer, 65(3), 398-409 (2013-03-28)
Associations between caffeine and coffee consumption and breast cancer risk are uncertain, with studies suggesting inverse and null associations. Variation in cytochrome P450 1A2 (CYP1A2), a gene responsible for caffeine metabolism, may modify these associations. Cases (n = 3,062) were
Rachel A Newman et al.
Perceptual and motor skills, 116(1), 280-293 (2013-07-09)
Naps are an effective strategy for maintaining alertness and cognitive performance; however, upon abrupt wakening from naps, sleep inertia (temporary performance degradation) may ensue. In the present study, attenuation of post-nap sleep inertia was attempted by administration of caffeine gum.
M Sandeep et al.
Indian journal of experimental biology, 52(12), 1165-1172 (2015-02-06)
Meclizine and caffeine combination is used for the treatment of morning sickness. Both compounds are teratogenic and caffeine is known to possess anti-fertility activity also. The present study was undertaken to evaluate the reproductive toxic effect of meclizine and caffeine
Samuel W Cramer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(14), 5664-5679 (2015-04-10)
The Ca(2+) channelopathies caused by mutations of the CACNA1A gene that encodes the pore-forming subunit of the human Cav2.1 (P/Q-type) voltage-gated Ca(2+) channel include episodic ataxia type 2 (EA2). Although, in EA2 the emphasis has been on cerebellar dysfunction, patients
Min Cheng et al.
The Canadian journal of cardiology, 30(4), 448-454 (2014-04-01)
The association between habitual caffeine intake with incident atrial fibrillation (AF) was unknown. We conducted a meta-analysis to investigate the association between chronic exposure of caffeine and the risk of AF and to evaluate the potential dose-response relation. We searched
S Uccella et al.
British journal of cancer, 109(7), 1908-1913 (2013-09-12)
Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously. Prospective cohort of 23,356 postmenopausal women with 471 Type I and 71 Type II EC cases. Type I
G D'Arena et al.
International journal of immunopathology and pharmacology, 26(1), 117-125 (2013-03-27)
Regulatory T cells (Tregs) are considered to be key immunomodulatory cells of the immune system and are increased in chronic lymphocytic leukemia (CLL). Rai stage 0 identifies patients with early stage CLL for which there is no effective intervention at
Yu-Chi Liu et al.
PLoS genetics, 10(3), e1004209-e1004209 (2014-03-22)
The olfactory systems of insects are fundamental to all aspects of their behaviour, and insect olfactory receptor neurons (ORNs) exhibit exquisite specificity and sensitivity to a wide range of environmental cues. In Drosophila melanogaster, ORN responses are determined by three
Youjin Je et al.
The British journal of nutrition, 111(7), 1162-1173 (2013-11-28)
Coffee consumption has been shown to be associated with various health outcomes, but no comprehensive review and meta-analysis of the association between coffee consumption and total mortality has been conducted. To quantitatively assess this association, we conducted a meta-analysis of
Zhi-Qiang Chang et al.
Journal of aquatic animal health, 26(4), 272-277 (2014-11-05)
Cytochrome P450s (CYPs) are the main catalytic enzymes for metabolism by a variety of endogenous and exogenous substrates in mammals, fish, insects, etc. We evaluated the application of a multidrug cocktail on changes in CYP1, CYP2, and CYP3 activity in
In-Ah Lee et al.
Journal of gastroenterology, 49(8), 1206-1216 (2013-08-09)
The initial trigger of inflammatory bowel disease (IBD) can be partly attributed towards the interaction and invasion of intestinal epithelial cells (IECs) and submucosal compartments. Identifying safe and economical methods to block these interactions may help prevent the onset of
Yueming Zhou et al.
The Analyst, 139(21), 5387-5392 (2014-08-26)
Better sensitivity and interface of ambient sampling/ionization mass spectrometry remain a challenge. Herein, a novel, plasma-based, ambient sampling/ionization/transmission (PASIT) integrated source in a pin-to-funnel configuration was developed for the sensitive analysis of complex samples. With the funnel sleeve directly affected
Surajit Sahu et al.
Experimental neurology, 248, 470-481 (2013-08-08)
It has been established that sleep deprivation (SD) reduces the proliferation of neuronal precursors in the adult hippocampus. It has also been reported that psychostimulant drugs modulate adult neurogenesis. We examined the modulatory role of two psychostimulant drugs modafinil and
Chikako Kiyohara et al.
Arthritis care & research, 66(7), 1048-1056 (2014-01-29)
N-acetyltransferase 2 (NAT2) is involved in the metabolism of various environmental substances, both with and without carcinogenic potential. Alcoholic and nonalcoholic caffeine-rich beverages may be associated with markers of inflammation. Systemic lupus erythematosus (SLE) is a chronic, multifaceted inflammatory disease.
Nancy N Maserejian et al.
American journal of epidemiology, 177(12), 1399-1410 (2013-06-01)
Evidence to substantiate recommendations for restriction of caffeinated or acidic beverages as self-management for lower urinary tract symptoms (LUTS) is limited. We examined longitudinal and acute associations between beverage intake and LUTS in the Boston Area Community Health (BACH) cohort
Markus Fehrholz et al.
PloS one, 9(5), e97357-e97357 (2014-05-16)
Caffeine administration is an important part of the therapeutic treatment of bronchopulmonary dysplasia (BPD) in preterm infants. However, caffeine mediated effects on airway remodelling are still undefined. The TGF-Ī²/Smad signalling pathway is one of the key pathways involved in airway
Regina Wierzejska
Roczniki Panstwowego Zakladu Higieny, 63(2), 141-147 (2012-08-30)
Caffeine is widely consumed by people of all ages. In the last period a market of caffeine-containing products, particularly energy drinks and food supplements increased. Caffeine for years is under discussion, whether has positive whether adverse impact on health. Children
Mariana N Batista et al.
Archives of virology, 160(2), 399-407 (2014-12-11)
Hepatitis C is considered the major cause of cirrhosis and hepatocellular carcinoma. Conventional treatment is not effective against some hepatitis C virus (HCV) genotypes; therefore, new treatments are needed. Coffee and, more recently, caffeine, have been found to have a
Martin KronschlƤger et al.
Experimental eye research, 127, 179-183 (2014-08-12)
The aim of the present study was to examine if topically applied caffeine influences pupil size in ketamine/xylazine anesthetized animals. Two experiments were carried out. In the first experiment, caffeine was topically applied to one of the eyes of 10
Anne-Laure Gassner et al.
Journal of chromatography. A, 1353, 121-130 (2014-06-14)
Procedures for estimating the measurement uncertainty (MU) of the concentration of a given analyte in a sample are of major concern for analytical chemists. Unfortunately, it is still unclear how and why MU should be assessed. While several possibilities exist
Dimitrios Moustakas et al.
PloS one, 10(4), e0123310-e0123310 (2015-04-17)
The stimulant effect of energy drinks is primarily attributed to the caffeine they contain. Many energy drinks also contain other ingredients that might enhance the tonic effects of these caffeinated beverages. One of these additives is guarana. Guarana is a
Kathleen T Sachse et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 28(2), 395-401 (2007-08-09)
Caffeine, the most widely consumed psychoactive drug and a weak adenosine receptor antagonist, can be neuroprotective or neurotoxic depending on the experimental model or neurologic disorder. However, its contribution to pathophysiology and outcome in traumatic brain injury (TBI) in humans
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