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Showing 1-30 of 277 results for "PHR1106" within Papers
Shewit Kalayou et al.
Cell biology and toxicology, 30(6), 361-376 (2014-11-25)
The mycotoxin alternariol (AOH) is an important contaminant of fruits and cereal products. The current study sought to address the effect of a non-toxic AOH concentration on the proteome of the steroidogenic H295R cell model. Quantitative proteomics based on stable
Amelia Barilli et al.
Biochimica et biophysica acta, 1842(9), 1364-1371 (2014-05-06)
Celiac disease (CD) is an autoimmune enteropathy triggered in susceptible individuals by the ingestion of gliadin-containing grains. Recent studies have demonstrated that macrophages play a key role in the pathogenesis of CD through the release of inflammatory mediators such as
Carina T Ribeiro et al.
The Journal of urology, 191(5 Suppl), 1578-1584 (2014-04-01)
We assessed reproductive and testicular function in adult rats after testicular torsion created before, during and after puberty, and with vs without resveratrol or arginine treatment. Age matched rats were divided into groups, including simulated surgery without testicular torsion, 720-degree
Naoki Aizawa et al.
Neurourology and urodynamics, 34(4), 368-374 (2014-02-18)
We measured single-unit mechanosensitive afferent activities (SAAs) during reflexic, rhythmic bladder contractions (RBCs), and examined whether L-arginine, an NO substrate, and mirabegron, a Ī²3-adrenoceptor agonist, and oxybutynin, an antimuscarinic agent, can affect the SAAs in such condition. Twenty-nine female Sprague-Dawley
Rachana Sainger et al.
The Journal of heart valve disease, 22(2), 156-165 (2013-06-27)
Aortic valve sclerosis (AVSc), the early asymptomatic stage of calcific aortic valve disease (CAVD), is characterized by a progressive thickening of the aortic cusps without obstruction of the left ventricular outflow. In spite of its high prevalence, there are no
L-Arginine modulates neonatal lymphocyte proliferation through an interleukin-2 independent pathway.
Yu HR, Kuo HC, Huang LT, et al.
Immunology, 143(2), 184-192 (2014)
Anil Kumar et al.
The Journal of surgical research, 188(1), 268-279 (2014-02-04)
Traumatic head injury is turning out to be a major cause of disability and death. Nitric oxide (NO), an intercellular messenger plays a crucial role in the pathophysiology of several neurologic disorders. Therefore, the present study was designed to investigate
Isabelle Dunand-Sauthier et al.
Journal of immunology (Baltimore, Md. : 1950), 193(4), 1690-1700 (2014-07-11)
Arginine, a semiessential amino acid implicated in diverse cellular processes, is a substrate for two arginases-Arg1 and Arg2-having different expression patterns and functions. Although appropriately regulated Arg1 expression is critical for immune responses, this has not been documented for Arg2.
Pratima Tripathi et al.
Indian journal of biochemistry & biophysics, 50(2), 99-104 (2013-06-01)
Increased production of oxygen free radicals and decreased oxidant capacity occur in coronary artery diseases (CAD) This pro-oxidant shift in intracellular redox state may induce cell death by either direct cell membrane damage by lipic peroxidation or apoptosis through activation
IstvƔn TƩlessy
Orvosi hetilap, 155(51), 2021-2027 (2014-12-17)
Reviewing the literature of nutrition therapy one can conclude that during the last decade the pharmacological action of several nutrients has been demonstrated. However, research activity is still at the beginning and it could be verified in a restricted number
Jose CĆ³rdoba-ChacĆ³n et al.
Endocrinology, 154(7), 2393-2398 (2013-05-23)
l-arginine (l-Arg) rapidly stimulates GH and insulin release in vivo. It has been hypothesized that l-Arg stimulates GH release by lowering hypothalamic somatostatin (SST) tone. l-Arg may also act directly at the pituitary to stimulate GH release. Moreover, l-Arg has
Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma.
Philippe Bahadoran et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), e324-e326 (2013-05-30)
Ting-lei Gu et al.
PloS one, 6(4), e19169-e19169 (2011-05-10)
Activating mutations of FMS-like tyrosine kinase-3 (FLT3) are found in approximately 30% of patients with acute myeloid leukemia (AML). FLT3 is therefore an attractive drug target. However, the molecular mechanisms by which FLT3 mutations lead to cell transformation in AML
Zhenlong Wu et al.
Current opinion in clinical nutrition and metabolic care, 15(6), 529-538 (2012-10-19)
Brown adipose tissue (BAT), which is present in humans, plays an important role in oxidation of fatty acids and glucose. The purpose of this review is to highlight an important role for L-arginine in regulating BAT growth and development, thereby
Cinzia Franchin et al.
Biochimica et biophysica acta, 1854(6), 609-623 (2014-10-04)
CK2 is an extremely pleiotropic Ser/Thr protein kinase, responsible for the generation of a large proportion of the human phosphoproteome and implicated in a wide variety of biological functions. CK2 plays a global role as an anti-apoptotic agent, a property
Jiang-Rui Zhou et al.
Journal of neuroimmunology, 260(1-2), 55-59 (2013-04-30)
Despite increasing evidence highlighting the role of NPY in the modulation of inflammatory reaction, surprisingly little is known about the direct effects of NPY on the release of proinflammatory mediators. In the present work, we have evaluated the effects of
Jason R McKnight et al.
Amino acids, 39(2), 349-357 (2010-05-04)
Over the past 20 years, growing interest in the biochemistry, nutrition, and pharmacology of L-arginine has led to extensive studies to explore its nutritional and therapeutic roles in treating and preventing human metabolic disorders. Emerging evidence shows that dietary L-arginine
Xinyan Wu et al.
Nature communications, 5, 4961-4961 (2014-09-24)
The PIK3CA gene is frequently mutated in human cancers. Here we carry out a SILAC-based quantitative phosphoproteomic analysis using isogenic knockin cell lines containing 'driver' oncogenic mutations of PIK3CA to dissect the signalling mechanisms responsible for oncogenic phenotypes induced by
Aurelie Vivares et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(1), 29-44 (2014-07-30)
1. The quantitative prediction of the pharmacokinetic parameters of a drug from data obtained using human in vitro systems remains a significant challenge i.e. prediction of metabolic clearance in humans and estimation of the relative contribution of enzymes involved in
Reeder M Robinson et al.
Archives of biochemistry and biophysics, 550-551, 58-66 (2014-04-29)
The mechanism of Mycobacterium smegmatis G (MbsG), a flavin-dependent l-lysine monooxygenase, was investigated under steady-state and rapid reaction conditions using primary and solvent kinetic isotope effects, substrate analogs, pH and solvent viscosity effects as mechanistic probes. The results suggest that
Vitaly V Vostrikov et al.
Biochimica et biophysica acta, 1848(1 Pt B), 315-322 (2014-09-25)
Phospholamban (PLN) is a single-pass membrane protein that regulates the sarco(endo)plasmic reticulum CaĀ²āŗ-ATPase (SERCA). Phosphorylation of PLN at Ser16 reverses its inhibitory function under Ī²-adrenergic stimulation, augmenting CaĀ²āŗ uptake in the sarcoplasmic reticulum and muscle contractility. PLN exists in two
Hanning You et al.
American journal of physiology. Renal physiology, 307(11), F1292-F1301 (2014-10-17)
Our recent publication showed that pharmacological blockade of arginases confers kidney protection in diabetic nephropathy via a nitric oxide (NO) synthase (NOS)3-dependent mechanism. Arginase competes with endothelial NOS (eNOS) for the common substrate L-arginine. Lack of L-arginine results in reduced
Chika Fujii et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(12), 2457-2459 (2014-01-08)
Hand-foot syndrome( HFS) has been reported to be the most common adverse effect of capecitabine, with an incidence of more than 50%. AboundTM, containing Ī²-hydroxy-Ī²-methyl butyric acid( HMB), L-glutamine, and L-arginine is effective in the treatment of decubitus ulcers and
Sabina Leanti La Rosa et al.
Infection and immunity, 83(5), 2156-2167 (2015-03-18)
In the present study, the commensal and pathogenic host-microbe interaction of Enterococcus faecalis was explored using a Caenorhabditis elegans model system. The virulence of 28 E. faecalis isolates representing 24 multilocus sequence types (MLSTs), including human commensal and clinical isolates
Renata P Assis et al.
BMC nephrology, 16, 50-50 (2015-04-18)
In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that accumulate in CKD, we used in vitro model systems to
Kevin S Heffernan et al.
Journal of cardiovascular pharmacology and therapeutics, 15(1), 17-23 (2010-01-08)
With advancing age, peripheral conduit and resistance arteries lose the ability to effectively dilate owing to endothelial dysfunction. This vascular senescence contributes to increased risk of cardiovascular disease (CVD) with aging. L-arginine plays a role in numerous physiological processes including
A Martinsen et al.
Pflugers Archiv : European journal of physiology, 466(7), 1377-1389 (2013-10-29)
The Ca(2+)-dependent kinase myosin light chain kinase (MLCK) is the activator of smooth muscle contraction. In addition, it has been reported to be involved in Ca(2+) channel regulation in cultured cells, and we previously showed that the MLCK inhibitor ML-7
Matthew J Kan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(15), 5969-5982 (2015-04-17)
The pathogenesis of Alzheimer's disease (AD) is a critical unsolved question; and although recent studies have demonstrated a strong association between altered brain immune responses and disease progression, the mechanistic cause of neuronal dysfunction and death is unknown. We have
Jason M Fye et al.
The Journal of biological chemistry, 289(16), 11556-11565 (2014-03-13)
TREX1 is a 3'-deoxyribonuclease that degrades single- and double-stranded DNA (ssDNA and dsDNA) to prevent inappropriate nucleic acid-mediated immune activation. More than 40 different disease-causing TREX1 mutations have been identified exhibiting dominant and recessive genetic phenotypes in a spectrum of
[Endogenous metabolites--arginine/nitric oxide regulate the body's physiological function].
Wen-Qian Dong et al.
Sheng li ke xue jin zhan [Progress in physiology], 43(5), 334-337 (2013-01-16)
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