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Showing 1-30 of 915 results for "PHR1462" within Papers
Emmanuelle Berthelot et al.
European journal of clinical investigation, 44(10), 982-988 (2014-09-05)
Coupled arterial and left ventricular properties are poorly documented in acute heart failure. The aim of this prospective noninvasive study was to document early changes in ventricular-arterial coupling in patients with acutely decompensated HF (ADHF). We studied 19 patients hospitalized
Silvia Monticone et al.
The Journal of clinical endocrinology and metabolism, 100(1), E114-E118 (2014-10-17)
Familial hyperaldosteronism type III (FH-III) is a rare and clinically heterogeneous condition, that can display mild as well as severe phenotypes. Point mutations in the KCNJ5 gene, affecting the ion selectivity of the inward rectifier K(+) channel 4 (Kir3.4), underlie
Cristiano Sacchetti et al.
ACS nano, 8(12), 12280-12291 (2014-11-22)
Osteoarthritis (OA) is a common and debilitating degenerative disease of articular joints for which no disease-modifying medical therapy is currently available. Inefficient delivery of pharmacologic agents into cartilage-resident chondrocytes after systemic administration has been a limitation to the development of
Harjit Chahal et al.
Heart (British Cardiac Society), 101(1), 58-64 (2014-11-09)
Heart failure (HF) is a leading cause of mortality especially in older populations. Early detection of high-risk individuals is imperative for primary prevention. The purpose of this study was to develop a HF risk model from a population without clinical
Lisa Nezvitsky et al.
American journal of physiology. Renal physiology, 307(5), F634-F647 (2014-07-25)
The unfolded protein response and endoplasmic reticulum-associated degradation (ERAD) contribute to injury in renal glomerular diseases, including those mediated by complement C5b-9. In the present study, we address the role of protein-tyrosine phosphatase 1B (PTP1B) in complement-mediated glomerular injury and
T G Cotter et al.
Diabetes research and clinical practice, 106(3), e56-e59 (2014-12-03)
We sought to determine the attainment of targets for glycaemic control and vascular risk reduction in an Irish cohort of T1DM adults. Of 797 patients (53% male, mean age 40.3 ± 14.8 years, HbA1c 8.5 ± 1.6% (69.6 ± 17.8
Elena Ratto et al.
Journal of hypertension, 33(3), 605-611 (2014-11-27)
A new classification of left ventricular geometry based on left ventricular dilatation and concentricity has recently been developed. This classification identifies subgroups differing with regard to systemic haemodynamics, left ventricular function and cardiovascular prognosis. We investigated the relationship between the
Lucia A Possamai et al.
Liver international : official journal of the International Association for the Study of the Liver, 35(3), 764-773 (2014-09-23)
Variations in intestinal microbiota may influence acetaminophen metabolism. This study aimed to determine whether intestinal microbiota are a source of differential susceptibility to acetaminophen-induced hepatotoxicity. Conventionally housed C3H/HeH (CH) and C3H/HeH germ-free (GF) mice were administered a 200 mg/kg IP
Nikhil Sharma et al.
American journal of physiology. Renal physiology, 308(5), F400-F410 (2014-12-30)
High fructose intake has been associated with increased incidences of renal disease and hypertension, among other pathologies. Most fructose is cleared by the portal system and metabolized in the liver; however, systemic levels of fructose can rise with increased consumption.
Yusuke Gotoh et al.
Biochemical and biophysical research communications, 456(2), 670-675 (2014-12-17)
The Na(+)/Ca(2+) exchanger (NCX) is a bidirectional transporter that is controlled by membrane potential and transmembrane gradients of Na(+) and Ca(2+). Although two isoforms of NCX1 and NCX2 are coexpressed on the basolateral membrane of the distal nephron, the functional
Ki-Bum Won et al.
Coronary artery disease, 26(2), 150-156 (2014-10-31)
Compared with coronary computed tomographic angiography (CCTA), the coronary artery calcium score (CACS) may be limited in predicting adverse cardiovascular events in asymptomatic diabetic patients. We evaluated the predictive value of CACS for obstructive coronary plaques (OCPs) assessed by CCTA
Lenka Hošková et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 37(8), 724-732 (2014-04-11)
Chronic immunosuppressive therapy is often complicated by the development of both arterial hypertension and renal dysfunction. The principal aim of this study was to assess the effects of dual inhibition of renin-angiotensin system (RAS) and other antihypertensive treatment on blood
Wei Zheng et al.
The Journal of pharmacology and experimental therapeutics, 353(2), 288-298 (2015-02-24)
Small vessel vasculitis is a life-threatening condition and patients typically present with renal and pulmonary injury. Disease pathogenesis is associated with neutrophil accumulation, activation, and oxidative damage, the latter being driven in large part by myeloperoxidase (MPO), which generates hypochlorous
Monica Locatelli et al.
Journal of the American Society of Nephrology : JASN, 25(8), 1786-1798 (2014-03-01)
Shiga toxin (Stx)-producing Escherichia coli is the offending agent of postdiarrhea-associated hemolytic uremic syndrome (HUS), a disorder of glomerular ischemic damage and widespread microvascular thrombosis. We previously documented that Stx induces glomerular complement activation, generating C3a responsible for microvascular thrombosis
Jiao Liu et al.
Shock (Augusta, Ga.), 43(1), 31-38 (2014-09-26)
Sepsis is a major cause of acute kidney injury (AKI) with high rates of morbidity and mortality. Surfactant proteins A and D (SP-A, SP-D) play a critical role in host defense and regulate inflammation during infection. Recent studies indicate SP-A
Hanan Hagar et al.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 67(2), 133-141 (2014-12-10)
Cisplatin is one of the most potent chemotherapeutic antitumor drugs used in the treatment of a wide range of solid tumors. Its primary dose-limiting side effect is nephrotoxicity. This study aims to investigate the effect of betaine supplementation on cisplatin-induced
Orlando M Gutiérrez et al.
American journal of kidney diseases : the official journal of the National Kidney Foundation, 64(2), 204-213 (2014-04-01)
Nutrition is linked strongly with health outcomes in chronic kidney disease (CKD). However, few studies have examined relationships between dietary patterns and health outcomes in persons with CKD. Observational cohort study. 3,972 participants with CKD (defined as estimated glomerular filtration
Hsin-Fang Chung et al.
Clinical nutrition (Edinburgh, Scotland), 34(2), 229-234 (2014-04-12)
The n-3 polyunsaturated fatty acids (PUFAs) and the inflammatory indicator, interleukin-6 (IL-6), have been implied in the development of renal dysfunction. This longitudinal study examined the effect of n-3 PUFAs and IL-6 on the risk of renal function decline and
Feng He et al.
Diabetologia, 57(8), 1726-1736 (2014-06-09)
The contribution of aberrantly expressed microRNAs (miRNAs) to diabetic nephropathy in vivo is poorly understood. Integrated comparative miRNA array profiling was used to examine the expression of serum miRNAs in patients with diabetic nephropathy. The abundance of miRNA-135a (miR-135a) was
Axel C Carlsson et al.
Clinical journal of the American Society of Nephrology : CJASN, 9(8), 1393-1401 (2014-06-14)
Kidney injury molecule-1 (KIM-1) has been suggested as a clinically relevant highly specific biomarker of acute kidney tubular damage. However, community-based data on the association between urinary levels of KIM-1 and the risk for cardiovascular mortality are lacking. This study
J A Hall et al.
Veterinary journal (London, England : 1997), 202(3), 588-596 (2014-12-03)
The purpose of this study was to determine whether feeding cats reduced protein and phosphorus foods with added fish oil, L-carnitine, and medium-chain triglycerides (MCT) altered serum biomarkers of renal function. Thirty-two healthy cats, mean age 14.0 (8.3-19.6) years, were
C Ponticelli et al.
Transplantation proceedings, 46(10), 3375-3382 (2014-12-17)
This multicenter, randomized, prospective, controlled trial (EVIDENCE study) aimed to determine short-term effects of early steroid withdrawal in renal transplant patients initially treated with everolimus, low-dose cyclosporine (CsA), and steroids. Patients were randomized to standard triple therapy with CsA, everolimus
Raffaele Caruso et al.
Mediators of inflammation, 2014, 281790-281790 (2014-08-19)
The mechanical circulatory support (MCS) is an effective treatment in critically ill patients with end-stage heart failure (ESHF) that, however, may cause a severe multiorgan failure syndrome (MOFS) in these subjects. The impact of altered inflammatory response, associated to MOFS
Meyeon Park et al.
American heart journal, 168(6), 931-939 (2014-12-03)
Subclinical volume overload in the absence of diagnosed heart failure (HF) may be an underrecognized contributor to kidney function decline in coronary artery disease (CAD) patients. We evaluated associations of circulating N-terminal pro-B-type natriuretic peptide (NT-proBNP), a marker of ventricular
Mahbubur Rahman et al.
Nature communications, 5, 3944-3944 (2014-05-23)
The ketone body β-hydroxybutyrate (BHB) is an endogenous factor protecting against stroke and neurodegenerative diseases, but its mode of action is unclear. Here we show in a stroke model that the hydroxy-carboxylic acid receptor 2 (HCA2, GPR109A) is required for
Dominik Linz et al.
American journal of hypertension, 28(2), 256-265 (2014-07-16)
Hypertension and metabolic syndrome (MetS) are associated with increased sympathetic activation possibly contributing to the progression of renal damage and cardiac remodeling. Renal sympathetic denervation (RDN) decreases sympathetic renal efferent and afferent nerve activity. Obese spontaneously hypertensive rats (SHRs-ob) were
Chrysoula Christou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 964, 195-201 (2014-02-01)
In the current paper the analytical conditions for the determination of ten free organic acids by GC-MS are studied with the aim to establish a method for organic acid profiling in human urine to be used as a tool for
Wei-Xin Xiong et al.
Chinese medical journal, 128(6), 727-732 (2015-03-12)
We investigated whether and to what extent the ratio between circulating fibrinogen (Fg) and its degradation products (FDP) reflects the severity of coronary artery disease (CAD) in type 2 diabetic patients. Plasma levels of Fg and FDP were determined, and
J Walstab et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(6), 810-820 (2014-04-09)
Impaired 5-HT3 receptor function is likely involved in the pathogenesis of functional gastrointestinal disorders (FGID) and 5-HT3 receptor antagonists are effective treatments for chemotherapy-induced nausea and vomiting (CINV) and irritable bowel syndrome (IBS). The monoterpene alcohol menthol and the aporphine
Jonas Björk et al.
Clinical chemistry and laboratory medicine, 53(3), 403-414 (2014-10-03)
The recently established international cystatin C calibrator makes it possible to develop non-laboratory specific glomerular filtration rate (GFR) estimating (eGFR) equations. This study compares the performance of the arithmetic mean of the revised Lund-Malmö creatinine and CAPA cystatin C equations
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