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Showing 1-30 of 178 results for "R2500" within Papers
Ali El-Agamey et al.
Journal of photochemistry and photobiology. B, Biology, 212, 112023-112023 (2020-09-28)
Laser excitation of a single precursor, namely 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (HHEMP), has been used for generating the radical cations and radical anions of various carotenoids in methanol. In the presence of oxygen, laser excitation of HHEMP undergoes an efficient α-cleavage reaction (Norrish
Shiho Kawamura et al.
Structure (London, England : 1993), 21(3), 426-437 (2013-02-26)
Rhodopsin, the photoreceptor pigment of the retina, initiates vision upon photon capture by its covalently linked chromophore 11-cis-retinal. In the absence of light, the chromophore serves as an inverse agonist locking the receptor in the inactive dark state. In the
Lei Zhang et al.
Frontiers in bioscience (Scholar edition), 5, 661-671 (2013-01-02)
Abnormal migration of retinal pigment epithelium (RPE) contributes to a variety of disorders such as proliferative vitreoretinopathy. Here, the effect of epidermal growth factor (EGF), and signaling by its receptor (ERGR)/phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) on RPE cell migration
Lifen Jiang et al.
eLife, 9 (2020-01-22)
Many animals exhibit an astonishing ability to form groups of large numbers of individuals. The dynamic properties of such groups have been the subject of intensive investigation. The actual grouping processes and underlying neural mechanisms, however, remain elusive. Here, we
Nicolas Taveau et al.
Experimental & molecular medicine, 52(7), 1090-1101 (2020-07-10)
Environmental light has deleterious effects on the outer retina in human retinopathies, such as ABCA4-related Stargardt's disease and dry age-related macular degeneration. These effects involve carbonyl and oxidative stress, which contribute to retinal cell death and vision loss. Here, we
Yunchuan Zhang et al.
Current biology : CB, 31(6), 1337-1343 (2021-02-06)
Memory forms when a previously neutral stimulus (CS+) becomes competent to predict a biologically potent stimulus (US). However, if the CS+ is repeatedly presented without the US after the memory formation, this memory will be suppressed by newly formed extinction
Nicholas C Flytzanis et al.
Nature communications, 5, 4894-4894 (2014-09-16)
Probing the neural circuit dynamics underlying behaviour would benefit greatly from improved genetically encoded voltage indicators. The proton pump Archaerhodopsin-3 (Arch), an optogenetic tool commonly used for neuronal inhibition, has been shown to emit voltage-sensitive fluorescence. Here we report two
Soh Kohatsu et al.
Nature communications, 6, 6457-6457 (2015-03-07)
The courtship ritual of male Drosophila represents an innate behaviour that is initiated by female-derived sensory stimuli. Here we report that moving light spots can induce courtship-like following pursuit in tethered wild-type male flies provided the fly is primed by
Jiang Bian et al.
Chronobiology international, 37(12), 1677-1692 (2020-10-30)
As the circadian pacemaker of birds, the retina possesses the ability to receive light information, generate circadian oscillation, and secrete melatonin. Previous studies have confirmed that monochromatic green light can accelerate the circadian rhythmic expression of clock genes in the
Lieuwe Biewenga et al.
ACS omega, 5(5), 2397-2405 (2020-02-18)
The efficient engineering of iminium biocatalysis has drawn considerable attention, with many applications in pharmaceutical synthesis. Here, we report a tailor-made iminium-activated colorimetric "turn-on" probe, specifically designed as a prescreening tool to facilitate engineering of iminium biocatalysis. Upon complexation of
Lisha Shao et al.
Neuron, 102(5), 1025-1036 (2019-05-11)
Female behavior changes profoundly after mating. In Drosophila, the mechanisms underlying the long-term changes led by seminal products have been extensively studied. However, the effect of the sensory component of copulation on the female's internal state and behavior remains elusive.
Alexandria H Jaeger et al.
eLife, 7 (2018-10-12)
Each taste modality is generally encoded by a single, molecularly defined, population of sensory cells. However, salt stimulates multiple taste pathways in mammals and insects, suggesting a more complex code for salt taste. Here, we examine salt coding in Drosophila.
Keiichi Inoue et al.
Biochimica et biophysica acta, 1837(5), 562-577 (2013-06-05)
Retinal proteins (~rhodopsins) are photochemically reactive membrane-embedded proteins, with seven transmembrane α-helices which bind the chromophore retinal (vitamin A aldehyde). They are widely distributed through all three biological kingdoms, eukarya, bacteria and archaea, indicating the biological significance of the retinal
Elena G Govorunova et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(37), 22833-22840 (2020-09-03)
Channelrhodopsins are light-gated ion channels widely used to control neuronal firing with light (optogenetics). We report two previously unknown families of anion channelrhodopsins (ACRs), one from the heterotrophic protists labyrinthulea and the other from haptophyte algae. Four closely related labyrinthulea
Tadao Maeda et al.
Photochemistry and photobiology, 88(6), 1309-1319 (2012-03-21)
Accumulation of all-trans-retinal (all-trans-RAL), reactive vitamin A aldehyde, is one of the key factors in initiating retinal photodamage. This photodamage is characterized by progressive retinal cell death evoked by light exposure in both an acute and chronic fashion. Photoactivated rhodopsin
Optogenetic and pharmacologic dissection of feedforward inhibition in Drosophila motion vision
Mauss AS, et al.
The Journal of Neuroscience, 34(6), 2254-2263 (2014)
Tadao Maeda et al.
The Journal of biological chemistry, 288(48), 34484-34493 (2013-10-17)
Differentiated retinal pigmented epithelial (RPE) cells have been obtained from human induced pluripotent stem (hiPS) cells. However, the visual (retinoid) cycle in hiPS-RPE cells has not been adequately examined. Here we determined the expression of functional visual cycle enzymes in
Tatsuo S Okubo et al.
Neuron, 107(5), 924-940 (2020-07-19)
Spatial maps in the brain are most accurate when they are linked to external sensory cues. Here, we show that the compass in the Drosophila brain is linked to the direction of the wind. Shifting the wind rightward rotates the
Jeffrey L Rhoades et al.
Cell, 176(1-2), 85-97 (2018-12-26)
Animals must respond to the ingestion of food by generating adaptive behaviors, but the role of gut-brain signaling in behavioral regulation is poorly understood. Here, we identify conserved ion channels in an enteric serotonergic neuron that mediate its responses to
Marc C Liggins et al.
Journal of immunology (Baltimore, Md. : 1950), 203(6), 1589-1597 (2019-08-20)
A subset of dermal fibroblasts undergo rapid differentiation into adipocytes in response to infection and acutely produce the cathelicidin antimicrobial peptide gene Camp Vitamin A and other retinoids inhibit adipogenesis yet can show benefit to skin disorders, such as cystic
Eugenia Poliakov et al.
PloS one, 7(11), e49975-e49975 (2012-12-05)
In order to maintain visual sensitivity at all light levels, the vertebrate eye possesses a mechanism to regenerate the visual pigment chromophore 11-cis retinal in the dark enzymatically, unlike in all other taxa, which rely on photoisomerization. This mechanism is
Yujia Hu et al.
Current biology : CB, 30(24), 4896-4909 (2020-10-17)
Sensory stimuli with graded intensities often lead to yes-or-no decisions on whether to respond to the stimuli. How this graded-to-binary conversion is implemented in the central nervous system (CNS) remains poorly understood. Here, we show that graded encodings of noxious
Javier Valdes-Aleman et al.
Neuron, 109(1), 105-122 (2020-10-30)
The mechanisms by which synaptic partners recognize each other and establish appropriate numbers of connections during embryonic development to form functional neural circuits are poorly understood. We combined electron microscopy reconstruction, functional imaging of neural activity, and behavioral experiments to
Tadao Maeda et al.
Investigative ophthalmology & visual science, 54(1), 455-466 (2012-12-20)
Investigate whether retinas of mice with impaired retinal cycles exposed to light or kept in the dark tolerate prolonged high-dose administration of QLT091001, which contains as an active ingredient, the 9-cis-retinal precursor, 9-cis-retinyl acetate. Four- to six-week-old Lrat(-/-) and Rpe65(-/-)
Ye Zhang et al.
Nature communications, 10(1), 1560-1560 (2019-04-07)
In the Drosophila antenna, different subtypes of olfactory receptor neurons (ORNs) housed in the same sensory hair (sensillum) can inhibit each other non-synaptically. However, the mechanisms underlying this underexplored form of lateral inhibition remain unclear. Here we use recordings from
Mitsumasa Koyanagi et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(13), 4998-5003 (2013-03-13)
Most opsins selectively bind 11-cis retinal as a chromophore to form a photosensitive pigment, which underlies various physiological functions, such as vision and circadian photoentrainment. Recently, opsin 3 (Opn3), originally called encephalopsin or panopsin, and its homologs were identified in
Eglof Ritter et al.
The Journal of biological chemistry, 288(15), 10451-10458 (2013-02-27)
Channelrhodopsins are microbial type rhodopsins that operate as light-gated ion channels. Largely prolonged lifetimes of the conducting state of channelrhodopsin-2 may be achieved by mutations of crucial single amino acids, i.e. cysteine 128. Such mutants are of great scientific interest
Ulrike Scheib et al.
Science signaling, 8(389), rs8-rs8 (2015-08-14)
Blastocladiomycota fungi form motile zoospores that are guided by sensory photoreceptors to areas of optimal light conditions. We showed that the microbial rhodopsin of Blastocladiella emersonii is a rhodopsin-guanylyl cyclase (RhGC), a member of a previously uncharacterized rhodopsin class of
Lei Li et al.
Cell reports, 28(11), 2979-2995 (2019-09-12)
Munc13 proteins play several roles in regulating short-term synaptic plasticity. However, the underlying molecular mechanisms remain largely unclear. Here we report that C. elegans UNC-13L, a Munc13-1 ortholog, has three domains that inhibit synaptic vesicle (SV) exocytosis. These include the X
Cheng-Yi Chiang et al.
Enzyme and microbial technology, 139, 109585-109585 (2020-08-01)
The undecaprenyl pyrophosphate phosphatase (UppP) is an integral membrane pyrophosphatase. In bacteria, UppP catalyzes the dephosphorylation of undecaprenyl pyrophosphate (C55-pp) to undecaprenyl phosphate (C55-P) in the periplasmic space, which is an essential step for the isoprenyl lipid carrier to reenter
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