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Showing 1-30 of 706 results for "R3501" within Papers
Shamaila Tahir et al.
Materials (Basel, Switzerland), 11(5) (2018-05-19)
To investigate the effect of negative pressure wound therapy (NPWT) with and without instillation (NPWTi) on in vitro mature biofilm. Mature biofilms of Pseudomonas aeruginosa and Staphylococcus aureus were grown under shear (130 rpm) on polycarbonate coupons in a CDC
Milu T Cherian et al.
Molecular pharmacology, 87(5), 878-889 (2015-03-13)
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are xenobiotic sensors that enhance the detoxification and elimination of xenobiotics and endobiotics by modulating the expression of genes encoding drug-metabolizing enzymes and transporters. Elevated levels of drug-metabolizing enzymes and efflux
A H Diacon et al.
Antimicrobial agents and chemotherapy, 51(8), 2994-2996 (2007-05-23)
We studied the early bactericidal activity of twice the standard dose of rifampin in subjects with pulmonary tuberculosis evidenced by positive smears. The observed mean 2-day activity was almost double that reported at the standard dose. Further studies are warranted
[Antibiotic regimens in tuberculous meningitis].
Ingrid Skinlo Rokstad
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 133(3), 278-278 (2013-04-06)
Toshihiro Sato et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 17(4), 475-484 (2015-01-13)
Organic anion-transporting polypeptide (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of numerous drugs. Thus, reduced OATP1B1 and OATP1B3 activity in chronic kidney disease (CKD) may have a major impact on the hepatic clearance of drugs. The effect of drug-uremic
Nitin Nema et al.
Middle East African journal of ophthalmology, 21(2), 189-192 (2014-05-03)
Paradoxical response to anti-tubercular drugs remains a diagnostic dilemma. In India where tuberculosis is quite prevalent, paradoxical response to anti-tubercular treatment (ATT) is either misdiagnosed or under-diagnosed. We report two cases of optochiasmatic arachnoiditis due to paradoxical response in children
Sarah K Lawrence et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1180-1190 (2014-04-22)
Dabrafenib is a potent ATP-competitive inhibitor for the V600 mutant b-rapidly accelerated fibrosarcoma (b-raf) kinase currently approved in the United States for the treatment of metastatic melanoma. Studies were conducted in human liver microsomes, recombinant human cytochrome P450 (P450) enzymes
Noriyuki Hatsugai et al.
Bio-protocol, 8(5), e2758-e2758 (2018-03-05)
We describe a protocol to measure the electrolyte leakage from plant tissues, resulting from loss of cell membrane integrity, which is a common definition of cell death. This simple protocol is designed to measure the electrolyte leakage from a tissue
Gerald L Newton et al.
Bioorganic & medicinal chemistry, 19(13), 3956-3964 (2011-06-15)
The mycothiol biosynthesis enzyme MshC catalyzes the ligation of cysteine with the pseudodisaccharide GlcN-Ins and has been identified as an essential enzyme in Mycobacterium tuberculosis. We now report on the development of NTF1836 as a micromolar inhibitor of MshC. Using
Karen L Stirrett et al.
Bioorganic & medicinal chemistry letters, 18(8), 2662-2668 (2008-04-09)
Drugs inhibiting the iron scarcity-induced, siderophore-mediated iron-scavenging systems of Mycobacterium tuberculosis (Mtb) and Yersinia pestis (Yp) may provide new therapeutic lines of defense. Compounds with structural similarities to siderophores were synthesized and evaluated as antimicrobials against Mtb and Yp under
Naeimeh Salehi et al.
Bioorganic chemistry, 83, 559-568 (2018-11-25)
A novel series of benzylpyridinium-based benzoheterocycles (benzimidazole, benzoxazole or benzothiazole) were designed as potent acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. The title compounds 4a-q were conveniently synthesized via condensation reaction of 1,2-phenylenediamine, 2-aminophenol or 2-aminothiophenol with pyridin-4-carbalehyde, followed by N-benzylation
Ethical issues in adapting new technologies for rapid diagnosis.
Richard A Cash
Indian journal of medical ethics, 10(4), 254-255 (2013-10-25)
Simone Hanna Brütsch et al.
Antioxidants & redox signaling, 22(4), 281-293 (2014-10-15)
Glutathione peroxidases (Gpx) and lipoxygenases (Alox) are functional counterplayers in the metabolism of hydroperoxy lipids that regulate cellular redox homeostasis. Gpx4 is a moonlighting protein that has been implicated not only as an enzyme in anti-oxidative defense, gene expression regulation
Radosław Izdebski et al.
Antimicrobial agents and chemotherapy, 51(4), 1155-1163 (2007-01-11)
The frequency of tetracycline resistance in Streptococcus pneumoniae isolates in Poland is one of the highest in Europe. The aim of this study was to analyze the clonal diversity and resistance determinants of tetracycline-nonsusceptible S. pneumoniae isolates identified in Poland
Toshiyuki Kudo et al.
Xenobiotica; the fate of foreign compounds in biological systems, 45(5), 413-419 (2014-12-04)
1. Blood levels of S-warfarin have been reported to be increased by concomitant administration of metronidazole (MTZ), an antiprotozoal imidazole derivative. 2. To elucidate the mechanism of this interaction and to identify other possible drug-drug interactions, we conducted an in
Yihao Zang et al.
iScience, 24(8), 102930-102930 (2021-08-20)
Cotton fiber is an excellent model for studying plant cell elongation and cell wall biogenesis as well because they are highly polarized and use conserved polarized diffuse growth mechanism. Fiber strength is an important trait among cotton fiber qualities due
Qingqing Huang et al.
Journal of medicinal chemistry, 52(21), 6757-6767 (2009-10-13)
The actual development and clinical use of new therapeutics for tuberculosis (TB) have remained stagnant for years because of the complexity of the disease process, the treatment of which at present requires the administration of drug combinations over a 6
Kozo Ochi et al.
Antimicrobial agents and chemotherapy, 53(1), 193-201 (2008-11-13)
The methyltransferases RsmG and KsgA methylate the nucleotides G535 (RsmG) and A1518 and A1519 (KsgA) in 16S rRNA, and inactivation of the proteins by introducing mutations results in acquisition of low-level resistance to streptomycin and kasugamycin, respectively. In a Bacillus
Viralkumar V Panchal et al.
PLoS pathogens, 16(7), e1008672-e1008672 (2020-07-25)
Most clinical MRSA (methicillin-resistant S. aureus) isolates exhibit low-level β-lactam resistance (oxacillin MIC 2-4 μg/ml) due to the acquisition of a novel penicillin binding protein (PBP2A), encoded by mecA. However, strains can evolve high-level resistance (oxacillin MIC ≥256 μg/ml) by
Do-Won Jeong et al.
International journal of food microbiology, 188, 108-115 (2014-08-12)
To select starters for jeotgal, a traditional Korean high-salt-fermented seafood, the safety and technological properties of its predominant bacteria isolates, which were identified as Staphylococcus equorum, were assessed. Among the 185 S. equorum isolates from jeotgal, 126 ampicillin-sensitive strains were
Yoshitomo Suhara et al.
Journal of medicinal chemistry, 54(13), 4918-4922 (2011-05-31)
Vitamin K(2) has been demonstrated to induce gene expression related to bone formation through a nuclear steroid and xenobiotic receptor (SXR). We synthesized new vitamin K analogues with the same isoprene side chains symmetrically introduced at the 2 and 3
Maria Elena Martino et al.
Cell host & microbe, 24(1), 109-119 (2018-07-17)
Animal-microbe facultative symbioses play a fundamental role in ecosystem and organismal health. Yet, due to the flexible nature of their association, the selection pressures that act on animals and their facultative symbionts remain elusive. Here we apply experimental evolution to
Laurent Poirel et al.
Antimicrobial agents and chemotherapy, 55(2), 934-936 (2010-12-01)
Seven carbapenem-resistant NDM-1-positive Klebsiella pneumoniae isolates were recovered from patients hospitalized between 2007 and 2009 in different wards at a referral and tertiary care center in Nairobi. Most of the isolates were obtained from urine. All isolates carried the bla(NDM-1)
Gde Sasmita Julyantoro Pande et al.
Applied microbiology and biotechnology, 99(24), 10805-10813 (2015-09-08)
Inactivation of quorum sensing (QS) signal molecules, such as acylhomoserine lactones (AHLs) of pathogenic bacteria, has been proposed as a novel method to combat bacterial diseases in aquaculture. Despite the importance of micro-algae for aquaculture, AHL degradation by bacteria associated
Lydia Hemala et al.
Research in microbiology, 165(6), 447-456 (2014-06-01)
Selection pressure in hydrocarbon-contaminated soils may lead not only to increased microbial resistance to antibiotics, but also to increased capacity of the soil indigenous population to produce antimicrobial compounds. Therefore, we studied the antibiotic resistance pattern and antibacterial and/or antifungal
Tomoshige Matsumoto et al.
Kekkaku : [Tuberculosis], 88(3), 291-296 (2013-05-16)
Multidrug resistance (MDR) involves resistance to both isoniazid and rifampicin, which makes the treatment of tuberculosis very difficult. Extensive drug resistance (XDR) occurs when, in addition to isoniazid and rifampicin resistance, the microorganisms are resistant to a fluoroquinolone and an
Conditionally fluorescent molecular probes for detecting single base changes in double-stranded DNA.
Sherry Xi Chen et al.
Nature chemistry, 5(9), 782-789 (2013-08-24)
Small variations in nucleic acid sequences can have far-reaching phenotypic consequences. Reliably distinguishing closely related sequences is therefore important for research and clinical applications. Here, we demonstrate that conditionally fluorescent DNA probes are capable of distinguishing variations of a single
Zuzana Svetlíková et al.
Antimicrobial agents and chemotherapy, 53(9), 4015-4018 (2009-07-08)
Nosocomial outbreaks attributable to glutaraldehyde-resistant, rapidly growing mycobacteria are increasing. Here, evidence is provided that defects in porin expression dramatically increase the resistance of Mycobacterium smegmatis and Mycobacterium chelonae to glutaraldehyde and another aldehyde disinfectant, ortho-phthalaldehyde. Since defects in porin
Srinivas Kantevari et al.
European journal of medicinal chemistry, 46(10), 4827-4833 (2011-07-05)
A series of novel hexahydro-2H-pyrano[3,2-c]quinoline analogues derived from dibenzo[b,d]furan and 9-methyl-9H-carbazole has been synthesized in very good yields through SnCl(2)·2H(2)O catalyzed one-pot Povarov reaction (imino-Diels-Alder reaction). The imines generated in situ from dibenzo[b,d]furan-2-carbaldehyde or 9-methyl-9H-carbazole-3-carbaldehyde and aromatic amines, were reacted
Mohamed Jawed Ahsan et al.
Bioorganic & medicinal chemistry letters, 21(18), 5259-5261 (2011-08-03)
In the present investigation, a series of 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues were synthesized and were evaluated for antitubercular activity by two fold serial dilution technique. All the newly synthesized compounds showed low to high inhibitory activities against Mycobacterium tuberculosis H(37)Rv and INH
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