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Showing 1-30 of 169 results for "R4642" within Papers
Katrine B V Greve et al.
Molecular oncology, 9(2), 437-449 (2014-11-05)
SSX cancer/testis antigens are frequently expressed in melanoma tumors and represent attractive targets for immunotherapy, but their role in melanoma tumorigenesis has remained elusive. Here, we investigated the cellular effects of SSX2 expression. In A375 melanoma cells, SSX2 expression resulted
Marina Eyngor et al.
Journal of clinical microbiology, 52(12), 4137-4146 (2014-09-19)
Tilapines are important for the sustainability of ecological systems and serve as the second most important group of farmed fish worldwide. Significant mortality of wild and cultured tilapia has been observed recently in Israel. The etiological agent of this disease
Vincenzo Carbone et al.
Proteins, 81(11), 2064-2070 (2013-07-23)
Methenyltetrahydromethanopterin cyclohydrolase (Mch) is involved in the methanogenesis pathway of archaea as a C1 unit carrier where N(5) -formyl-tetrahydromethanopterin is converted to methenyl-tetrahydromethanopterin. Mch from Methanobrevibacter ruminantium was cloned, purified, crystallized and its crystal structure solved at 1.37 Å resolution.
Omer Schwartzman et al.
Nature methods, 13(8), 685-691 (2016-07-05)
We developed a targeted chromosome conformation capture (4C) approach that uses unique molecular identifiers (UMIs) to derive high-complexity quantitative chromosome contact profiles with controlled signal-to-noise ratios. UMI-4C detects chromosomal interactions with improved sensitivity and specificity, and it can easily be
Gabriel E Neurohr et al.
Cell, 176(5), 1083-1097 (2019-02-12)
Cell size varies greatly between cell types, yet within a specific cell type and growth condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size is important remains poorly understood. Here we show that growing budding
Anna On-Yee Chan et al.
Chemical communications (Cambridge, England), 49(14), 1428-1430 (2013-01-17)
A new approach for selective modification of cysteine-containing peptides through gold-mediated oxidative allene-thiol coupling reaction in aqueous medium is developed.
Cyanobacterial Harmful Bloom Lipopolysaccharides Induce Pro-Inflammatory Effects in Immune and Intestinal Epithelial Cells In Vitro.
SkoA?kov?!, et al.
Toxins, 15 (2023)
Aja M Rieger et al.
Methods in molecular biology (Clifton, N.J.), 1389, 209-220 (2016-07-28)
The number of investigators using cell death analysis applications has greatly expanded since the introduction of flow cytometry. The Annexin V/propidium iodide (PI) method is among the most commonly used procedures and allows users to determine if cells are viable
Kung-Chi Chang et al.
Nature communications, 11(1), 6438-6438 (2020-12-24)
Misregulation of long non-coding RNA (lncRNA) genes has been linked to a wide variety of cancer types. Here we report on Mammary Tumor Associated RNA 25 (MaTAR25), a nuclear enriched and chromatin associated lncRNA that plays a role in mammary
Ann Boija et al.
Cell, 175(7), 1842-1855 (2018-11-20)
Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DBDs) and activation domains (ADs). The DBDs have been well characterized, but little is known about the mechanisms by which ADs effect gene activation. Here, we report
Panote Prapansilp et al.
Malaria journal, 12, 50-50 (2013-02-07)
Plasma angiopoietin (Ang)-2 is associated with disease severity and mortality in adults and children with falciparum malaria. However the mechanism of action of the angiopoietins in fatal malaria is unclear. This study aimed to determine whether the expression of Ang-1
Xi Chen et al.
Organic & biomolecular chemistry, 11(2), 353-361 (2012-11-23)
Site-selective labeling of endogenous proteins represents a major challenge in chemical biology, mainly due to the absence of unique reactive groups that can be addressed selectively. Recently, we have shown that surface-exposed lysine residues of two endogenous proteins and a
Shlomi Dvir et al.
Cell reports, 35(9), 109198-109198 (2021-06-03)
Embryonic stem cell (ESC) self-renewal and cell fate decisions are driven by a broad array of molecular signals. While transcriptional regulators have been extensively studied in human ESCs (hESCs), the extent to which RNA-binding proteins (RBPs) contribute to human pluripotency
Vincenzo Carbone et al.
The Journal of biological chemistry, 290(35), 21690-21704 (2015-07-16)
One of the most critical events in the origins of cellular life was the development of lipid membranes. Archaea use isoprenoid chains linked via ether bonds to sn-glycerol 1-phosphate (G1P), whereas bacteria and eukaryotes use fatty acids attached via ester
G C Allen et al.
Nature protocols, 1(5), 2320-2325 (2007-04-05)
We describe a modification of the DNA extraction method, in which cetyltrimethylammonium bromide (CTAB) is used to extract nucleic acids from plant tissues. In contrast to the original method, the modified CTAB procedure is faster, omits the selective precipitation and
Jia-En Wu et al.
Theranostics, 10(19), 8903-8923 (2020-08-06)
The loss of cancer-cell junctions and escape from the primary-tumor microenvironment are hallmarks of metastasis. A tight-junction protein, Claudin 1 (CLDN1), is a metastasis suppressor in lung adenocarcinoma. However, as a metastasis suppressor, the underlying molecular mechanisms of CLDN1 has
Teresa Rossi et al.
Journal of experimental & clinical cancer research : CR, 42(1), 7-7 (2023-01-06)
Triple-Negative Breast Cancer (TNBC) is a subtype of breast cancer that differs from other types of breast cancers in the faster spread and worse outcome. TNBC presented limited treatment options. BET (Bromodomain and extra-terminal domain) proteins are epigenetic readers that
Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions.
Chu, C., et al.
Molecular Cell (2011)
Reem Abu Rass et al.
Journal of virology, 96(6), e0175721-e0175721 (2022-02-03)
Emerging viruses impose global threats to animal and human populations and may bear novel genes with limited homology to known sequences, necessitating the development of novel approaches to infer and test protein functions. This challenge is dramatically evident in tilapia
Ao Chen et al.
Cell, 185(10), 1777-1792 (2022-05-06)
Spatially resolved transcriptomic technologies are promising tools to study complex biological processes such as mammalian embryogenesis. However, the imbalance between resolution, gene capture, and field of view of current methodologies precludes their systematic application to analyze relatively large and three-dimensional
Tanzina Tanu et al.
RNA biology, 18(sup1), 537-547 (2021-09-03)
Many long noncoding RNAs (lncRNAs) are localized in the nucleus and play important roles in various biological processes, including cell proliferation, differentiation and antiviral response. Yet, it remains unclear how some nuclear lncRNAs are turned over. Here we show that
Suraj Radhamani et al.
Investigational new drugs, 32(3), 424-435 (2014-03-15)
The DNA dependant protein kinase (DNA-PK) enzyme plays a major part in the repair of double stranded breaks induced by radiation and hence in the radio-resistance of tumour cells. Inhibitors of DNA-PK have been tested successfully in the past for
Yuen Lai Shek et al.
Biochemistry, 52(4), 672-680 (2013-01-09)
We report the first application of volume and compressibility measurements to characterization of interactions between cosolvents (osmolytes) and globular proteins. Specifically, we measure the partial molar volumes and adiabatic compressibilities of cytochrome c, ribonuclease A, lysozyme, and ovalbumin in aqueous
Imidazole C-2 hydrogen/deuterium exchange reaction at histidine for probing protein structure and function with matrix-assisted laser desorption ionization mass spectrometry.
Naoka Hayashi et al.
Biochemistry, 53(11), 1818-1826 (2014-03-13)
Christoph Neumayr et al.
Nature, 606(7913), 406-413 (2022-06-02)
All multicellular organisms rely on differential gene transcription regulated by genomic enhancers, which function through cofactors that are recruited by transcription factors1,2. Emerging evidence suggests that not all cofactors are required at all enhancers3-5, yet whether these observations reflect more
Alessandro Vergara et al.
Inorganic chemistry, 52(19), 10714-10716 (2013-10-08)
A Raman-assisted crystallographic study on the adduct between AziRu, a Ru(III) complex with high antiproliferative activity, and RNase A is presented. The protein structure is not perturbed significantly by the Ru label. The metal coordinates to ND atoms of His105
Srinivasan Damodaran
Biochemistry, 52(46), 8363-8373 (2013-10-26)
Cosolvents affect structural stability of proteins in aqueous solutions. A clear understanding of the mechanism by which cosolvents impact protein stability is critical to understanding protein folding in a biological milieu. In this study, we investigated the Lifshitz-van der Waals
Johan Aarum et al.
EMBO reports, 21(10), e49585-e49585 (2020-09-19)
Most proteins in cell and tissue lysates are soluble. We show here that in lysate from human neurons, more than 1,300 proteins are maintained in a soluble and functional state by association with endogenous RNA, as degradation of RNA invariably
Marko Premzl
Molecular genetics and genomics : MGG, 289(2), 161-167 (2013-12-18)
The present study attempted to update comprehensive eutherian ribonuclease A gene data sets, using public eutherian genomic sequence data sets and new genomics and molecular evolution tests. Among 448 ribonuclease A potential coding sequences, the present analysis annotated 255 complete
Pauline Lejault et al.
Autophagy, 16(12), 2252-2259 (2020-05-19)
Guanine-rich DNA strands can form secondary structures known as G-quadruplexes (G4-DNA or G4s). G4-DNA is important for the regulation of replication and transcription. We recently showed that the expression of Atg7, a gene that is critical for macroautophagy/autophagy, is controlled
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