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Showing 1-30 of 706 results for "R5010" within Papers
Jiung-Pang Huang et al.
Journal of cardiovascular pharmacology, 72(5), 231-241 (2018-11-07)
We investigated whether resveratrol (RSV) can attenuate obesity and diabetes progression and improve diabetes-induced vascular dysfunction, and we attempted to delineate its underlying mechanisms. Male C57Bl/6 mice were administered a high-fat diet (HFD) for 17 weeks. Mice developed type 2
Yi Cai et al.
Die Pharmazie, 70(6), 399-403 (2015-07-21)
Resveratrol, a natural phenolic compound found in red grapes, has been reported to inhibit proliferation and induce apoptosis via regulation of AMPK signaling pathways in several cancer cell types. However, little is known about the effect of resveratrol on the
Cedric J Lion et al.
Journal of medicinal chemistry, 48(4), 1292-1295 (2005-02-18)
The parallel solution-phase synthesis of a series of 30 monohydroxylated (E)-stilbene analogues is described. In vitro screening revealed low micromolar activity (GI(50)) against the MDA MB 468 breast cancer cell line. Activity in MDA MB 468 cells correlated with the
Satya Dash et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(12), 2895-2901 (2013-09-28)
Overproduction of hepatic apolipoprotein B (apoB)-100 containing very low-density lipoprotein particles and intestinal apoB-48 containing chylomicrons contributes to hypertriglyceridemia seen in conditions such as obesity and insulin resistance. Some, but not all, preclinical and clinical studies have demonstrated that the
João Paulo Silva Nunes et al.
Frontiers in immunology, 12, 755862-755862 (2021-12-07)
Infection by the protozoan Trypanosoma cruzi causes Chagas disease cardiomyopathy (CCC) and can lead to arrhythmia, heart failure and death. Chagas disease affects 8 million people worldwide, and chronic production of the cytokines IFN-γ and TNF-α by T cells together
Tiantian Liu et al.
Journal of virology, 88(8), 4229-4236 (2014-01-31)
Respiratory syncytial virus (RSV) is the most important cause of lower respiratory tract infection in young children and the leading cause of infant hospitalization worldwide. Uncontrolled response to RSV is mediated by a toll-like receptor (TLR)-mediated immune response. Resveratrol possesses
Bin Liu et al.
Molecular medicine reports, 10(4), 1697-1702 (2014-07-23)
The present study compared the effect of resveratrol on HCT116 and Caco-2 human colon cancer cells. Annexin V/propidium iodide staining, MTT assay and western blot analysis revealed that resveratrol induced cycle arrest in the two cell lines, which was evidenced
Salah O Bashir
Archives of physiology and biochemistry, 125(2), 104-113 (2018-02-14)
This study investigated if a combination of resveratrol (RES) and insulin could reverse type 1 diabetic mellitus-induced (T1DM) nephropathy and illustrates mechanism of action. Rats were divided into six groups (n = 10/group) as follows: control, control + RES (20 mg/kg), T1DM, T1DM + RES, T1DM + insulin (1 U/g)
Yusufhan Yazir et al.
Physiology & behavior, 138, 297-304 (2014-12-03)
A number of studies have recently focused on the neuroprotective and anti-inflammatory effects of resveratrol. In prior studies, we described its beneficial effects on scopolamine-induced learning deficits in rats. The aim of this study was to investigate the effects of
Y Irnidayanti et al.
Brazilian journal of biology = Revista brasleira de biologia, 82, e235781-e235781 (2021-04-01)
Resveratrol, a natural polyphenol found in tempeh, has not been investigated especially in vitro as a neuroprotective agent against 2-methoxyethanol (2-ME)-induced beta-amyloid cytotoxicity. Beta amyloid peptides (Aβ) could initiate neurotoxic events and neuron-inflammatory response via microglial activation. However, it remains
Fan Du et al.
Frontiers in microbiology, 12, 611323-611323 (2021-03-13)
Resveratrol (RSV) is a potential alternative therapy for non-alcoholic fatty liver disease (NAFLD) that has been evaluated in many clinical trials, but the mechanisms of RSV action have not been fully elucidated. Recent studies suggested that the gut microbiota is
Nurcan Değirmencioğlu et al.
Food chemistry, 194, 587-594 (2015-10-17)
In this study, the changes in phenolic composition, total phenolic content, and antioxidant capacity of tarhanas supplemented with oat flour (OF) at the levels of 20-100% (w/w) after three drying treatments (sun-, oven-, and microwave drying) were investigated. A total
Agnes Csiszár et al.
The journals of gerontology. Series A, Biological sciences and medical sciences, 70(3), 303-313 (2014-03-20)
Resveratrol (3,4',5-trihydroxystilbene) is a plant-derived polyphenolic trans-stilbenoid, which exerts multifaceted antiaging effects. Here, we propose a novel delivery system for resveratrol, which significantly increases its cellular uptake into aged cells. Combination of resveratrol with a positively charged lipid component to
Eun Sung Kim et al.
PloS one, 10(5), e0128078-e0128078 (2015-05-30)
Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) secrete various beneficial molecules, which have anti-apoptotic activity and cell proliferation. However, the effect of hUCB-MSCs in melanogenesis is largely unclear. In this study, we show that conditioned media (CM) derived from
Rana Barakat et al.
MicrobiologyOpen, 3(1), 1-14 (2013-12-07)
The blue-green phenazine, Pyocyanin (PYO), is a well-known virulence factor produced by Pseudomonas aeruginosa, notably during cystic fibrosis lung infections. It is toxic to both eukaryotic and bacterial cells and several mechanisms, including the induction of oxidative stress, have been
Alba Serrano et al.
Nutrients, 12(2) (2020-02-16)
Neonatal supplementation with resveratrol (RSV) or nicotinamide riboside (NR) programs in male mice brown adipocyte-like features in white adipose tissue (WAT browning) together with improved metabolism in adulthood. We tested the involvement in this programming of long-term epigenetic changes in
Yajing Ma et al.
Brain, behavior, and immunity, 87, 455-464 (2020-02-01)
Patients with temporomandibular disorders (TMDs) often experience persistent facial pain. However, the treatment of TMD pain is still inadequate. In recent years, the disturbance of gut microbiota has been shown to play an important role in the pathogenesis of different
Paula Aranaz et al.
Molecules (Basel, Switzerland), 24(6) (2019-03-20)
Phenolic compounds might modulate adiposity. Here, we report our observation that polyphenols and phenolic acids inhibit adipogenesis in 3T3-L1 with different intensity depending on the family and the stage of differentiation. While quercetin and resveratrol inhibited lipid accumulation along the
Jin-Ah Lee et al.
Nutrients, 7(11), 9650-9661 (2015-11-28)
The aim of this study was to improve the anti-inflammatory activities of apigenin through co-treatment with resveratrol as a bioenhancer of apigenin. RAW 264.7 cells pretreated with hepatic metabolites formed by the co-metabolism of apigenin and resveratrol (ARMs) in HepG2
Wei Zhu et al.
Nutrition & metabolism, 11, 35-35 (2014-08-21)
The exact mechanism of the protective role of Resveratrol (Res) in lipid metabolism and oxidative stress is not well elucidated. The present study aimed to investigate the potential benefits and possible mechanisms of Res on the amelioration of oxidative stress
Young-Hee Kim et al.
Diabetes, 59(7), 1825-1835 (2010-04-29)
This study investigated the effects of resveratrol, a natural polyphenol with neuroprotective properties, on retinal neuronal cell death mediated by diabetes-induced activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of
Anne Marie Thompson et al.
American journal of physiology. Heart and circulatory physiology, 307(4), H533-H541 (2014-06-29)
Loss of vascular smooth muscle cell (VSMC) function is a hallmark of vascular disease. VSMCs become increasingly dysregulated, apoptotic, and senescent as we age. Sirtuin 1 (SirT1) is a deactylase that regulates substrates associated with stress mitigation, metabolism, and aging.
Emilie André et al.
Stem cells and development, 28(22), 1498-1513 (2019-09-19)
Cardiac progenitor cells (CPCs) in the adult mammalian heart, as well as exogenous CPCs injected at the border zone of infarcted tissue, display very low differentiation rate into cardiac myocytes and marginal repair capacity in the injured heart. Emerging evidence
Alyssa A Sprouse et al.
Anticancer research, 34(10), 5363-5374 (2014-10-03)
Resveratrol (RES) inhibits cell growth, induces apoptosis and augments chemotherapeutics in multiple cancer types, although its effects on drug-resistant cancer cells are unknown. To study the effects of resveratrol in triple-negative breast cancer cells that are resistant to the common
Ban-Feng Ruan et al.
Bioorganic & medicinal chemistry, 19(8), 2688-2695 (2011-03-29)
Twenty-three resveratrol derivatives possessing chalcone moiety were synthesized and characterized, and their biological activities were also evaluated as potential antiproliferation and tubulin polymerization inhibitors. Compound C19 exhibited the most potent activity in vitro, which inhibited the growth of HepG2, B16-F10
Chen Huang et al.
Oncology reports, 33(2), 875-884 (2014-12-09)
Solid tumors grow faster and need more glucose than normal tissue; however, due to poor angiogenesis and excessive growth, tumors remote from blood vessels are always under glucose starvation. Even so, cancer cells remain alive in vivo. Thus, making cancer
Jyun-Bin Huang et al.
International journal of molecular sciences, 21(19) (2020-10-04)
Status epilepticus may cause molecular and cellular events, leading to hippocampal neuronal cell death. Peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) is an important regulator of vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR2), also known as fetal
Min Li Liu et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 19(3), 713-717 (2014-09-28)
This study aimed to investigate the effects of resveratrol on cell proliferation, apoptosis and protein expression of survivin in human gastric cancer (SGC7901) cell line. SGC7901 cell proliferation and G0/G1 phase of the cell cycle induced by resveratrol (treatment group)
Ke Ke et al.
Bone, 81, 237-246 (2015-07-15)
Emerging evidence suggests that microRNAs (miRs) influence skeletal structure by modulating osteoclastogenesis and bone resorption. We have demonstrated previously that the up-regulation of heme oxygenase-1 (HO-1) attenuated osteoclastogenesis in bone marrow-derived macrophages (BMMs). RANKL-induced osteoclastogenesis elevates microRNA-183 (miR-183) in BMM.
Tae Hyung Kim et al.
Biochimica et biophysica acta, 1840(1), 615-625 (2013-10-29)
Multidrug resistance is a major problem in the treatment of breast cancer, and a number of studies have attempted to find an efficient strategy with which to overcome it. In this study, we investigate the synergistic anticancer effects of resveratrol
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