RAB0246

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Showing 1-30 of 57 results for "RAB0246" within Papers

Novel G3/DT adjuvant promotes the induction of protective T cells responses after vaccination with a seasonal trivalent inactivated split-virion influenza vaccine.

Carolien E van de Sandt et al.

Vaccine, 32(43), 5614-5623 (2014-08-21)

Vaccines used against seasonal influenza are poorly effective against influenza A viruses of novel subtypes that may have pandemic potential. Furthermore, pre(pandemic) influenza vaccines are poorly immunogenic, which can be overcome by the use of adjuvants. A limited number of

Oral immunization with Lactococcus lactis-expressing EspB induces protective immune responses against Escherichia coli O157:H7 in a murine model of colonization.

B Ahmed et al.

Vaccine, 32(31), 3909-3916 (2014-06-01)

Enterohemorrhagic Escherichia coli (EHEC) have been responsible for several outbreaks of hemolytic-uremic syndrome (HUS) worldwide. HUS is the most common cause of acute renal failure in children and results in fatalities as high as 50% in the elderly. Currently, neither

Effect of zinc supplementation on E-ADA activity, seric zinc, and cytokines levels of Trypanosoma evansi infected Wistar rats.

Nathieli B Bottari et al.

Microbial pathogenesis, 74, 15-19 (2014-07-06)

The aim of this study was to evaluate the effect of zinc supplementation on the ecto-adenosine deaminase activity (E-ADA), zinc seric levels and cytokines (TNF-α, IL-1, IL-6, and IL -10) on rats experimentally infected by Trypanosoma evansi. Four groups with

Glyphosate-rich air samples induce IL-33, TSLP and generate IL-13 dependent airway inflammation.

Sudhir Kumar et al.

Toxicology, 325, 42-51 (2014-08-31)

Several low weight molecules have often been implicated in the induction of occupational asthma. Glyphosate, a small molecule herbicide, is widely used in the world. There is a controversy regarding a role of glyphosate in developing asthma and rhinitis among

Blockade of the T cell immunoglobulin and mucin domain protein 3 pathway exacerbates sepsis-induced immune deviation and immunosuppression.

Z Zhao et al.

Clinical and experimental immunology, 178(2), 279-291 (2014-06-20)

Sepsis is a life-threatening condition, but the pathophysiological basis and biomarkers for the monitoring of sepsis and as targets for therapy remain to be determined. We have shown previously that T cell immunoglobulin and mucin domain protein 3 (Tim-3), a

Investigation into in vitro and in vivo models using intestinal epithelial IPEC-J2 cells and Caenorhabditis elegans for selecting probiotic candidates to control porcine enterotoxigenic Escherichia coli.

M Zhou et al.

Journal of applied microbiology, 117(1), 217-226 (2014-03-29)

To identify a fast, economic and reliable method for preselecting lactic acid-producing bacterial (LAB) isolates to control enterotoxigenic Escherichia coli (ETEC). Two assays with porcine intestinal epithelial IPEC-J2 cells or Caenorhabditis elegans for selecting effective probiotic candidates were compared. Both

Structure elucidation and immunomodulatory activity of a beta glucan from the fruiting bodies of Ganoderma sinense.

Xiao-Qiang Han et al.

PloS one, 9(7), e100380-e100380 (2014-07-12)

A polysaccharide named GSP-2 with a molecular size of 32 kDa was isolated from the fruiting bodies of Ganoderma sinense. Its structure was well elucidated, by a combined utilization of chemical and spectroscopic techniques, to be a β-glucan with a

Controlling the activation of the Bv8/prokineticin system reduces neuroinflammation and abolishes thermal and tactile hyperalgesia in neuropathic animals.

D Maftei et al.

British journal of pharmacology, 171(21), 4850-4865 (2014-06-07)

Chemokines are involved in neuroinflammation and contribute to chronic pain processing. The new chemokine prokineticin 2 (PROK2) and its receptors (PKR1 and PKR2 ) have a role in inflammatory pain and immunomodulation. In the present study, we investigated the involvement

Prognostic value of circulating regulatory T cells for worsening heart failure in heart failure patients with reduced ejection fraction.

Naoko Okamoto et al.

International heart journal, 55(3), 271-277 (2014-05-13)

Regulatory T cells (Tregs) play a crucial role in the negative regulation of immune responses. Recent studies suggest that Tregs are involved in the pathogenesis of atherosclerosis and myocarditis. Here, we investigated the involvement of Tregs on worsening heart failure

Unique characteristics of human mesenchymal stromal/progenitor cells pre-activated in 3-dimensional cultures under different conditions.

Joni H Ylostalo et al.

Cytotherapy, 16(11), 1486-1500 (2014-09-19)

Human mesenchymal stromal cells (MSCs) are being used in clinical trials, but the best protocol to prepare the cells for administration to patients remains unclear. We previously demonstrated that MSCs could be pre-activated to express therapeutic factors by culturing the

Disequilibrium of M1 and M2 macrophages correlates with the development of experimental inflammatory bowel diseases.

Wei Zhu et al.

Immunological investigations, 43(7), 638-652 (2014-06-13)

Ulcerative colitis, a major inflammatory bowel disease, is an idiopathic inflammatory disorder of the colonic mucosa, accompanied by an aberrant immune reaction to intestinal microflora. Macrophages are central mediators of intestinal immune homeostasis and inflammation. The relationship between macrophages and

Insulin-like growth factor 2 enhances regulatory T-cell functions and suppresses food allergy in an experimental model.

Gui Yang et al.

The Journal of allergy and clinical immunology, 133(6), 1702-1708 (2014-04-05)

The functions of regulatory T (Treg) cells are important in immunity, and the regulatory mechanisms of Treg cell activities are not fully understood yet. We sought to investigate the role of insulin-like growth factor (IGF) 2 in the upregulation of

Chitosan-assisted immunotherapy for intervention of experimental leishmaniasis via amphotericin B-loaded solid lipid nanoparticles.

Vineet Jain et al.

Applied biochemistry and biotechnology, 174(4), 1309-1330 (2014-08-12)

Solid lipid nanoparticles (SLNs) have emerged as an excellent substitute over polymeric nanoparticles and, when incorporated with chitosan which activates the macrophage to impart an immune response, produce excellent results to fight against deleterious diseases like leishmaniasis where its parasite

Effect of hydrodynamics-based delivery of IL-18BP fusion gene on rat experimental autoimmune myocarditis.

He Chang et al.

Clinical and experimental medicine, 14(4), 397-408 (2013-10-15)

Interleukin-18 (IL-18) is a powerful and important cytokine in myocarditis. IL-18-binding protein (IL-18BP), a naturally occurring antagonist of IL-18, is presumed to play a vital regulatory function in IL-18-mediated immune responses. The purpose of this study was to evaluate the

Leishmania genome analysis and high-throughput immunological screening identifies tuzin as a novel vaccine candidate against visceral leishmaniasis.

Bhavana Sethu Lakshmi et al.

Vaccine, 32(30), 3816-3822 (2014-05-13)

Leishmaniasis is a neglected tropical disease caused by Leishmania species. It is a major health concern affecting 88 countries and threatening 350 million people globally. Unfortunately, there are no vaccines and there are limitations associated with the current therapeutic regimens

Effect of propranolol on IL-10, visfatin, Hsp70, iNOS, TLR2, and survivin in amelioration of tumor progression and survival in Solid Ehrlich Carcinoma-bearing mice.

Amany A Abdin et al.

Pharmacological reports : PR, 66(6), 1114-1121 (2014-12-03)

β-Adrenergic signaling could contribute to initiation and progression of breast cancer. This research investigated some potential mechanisms of propranolol in amelioration of progression and survival in breast cancer. Solid Ehrlich Carcinoma (SEC) xenograft model was induced in 30 mice divided

Differential response of human adipose tissue-derived mesenchymal stem cells, dermal fibroblasts, and keratinocytes to burn wound exudates: potential role of skin-specific chemokine CCL27.

Lenie J van den Broek et al.

Tissue engineering. Part A, 20(1-2), 197-209 (2013-08-29)

Many cell-based regenerative medicine strategies toward tissue-engineered constructs are currently being explored. Cell-cell interactions and interactions with different biomaterials are extensively investigated, whereas very few studies address how cultured cells will interact with soluble wound-healing mediators that are present within

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1.

Ian A Parish et al.

The Journal of clinical investigation, 124(8), 3455-3468 (2014-07-09)

During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression of

Human regulatory B cells combine phenotypic and genetic hallmarks with a distinct differentiation fate.

Wenyu Lin et al.

Journal of immunology (Baltimore, Md. : 1950), 193(5), 2258-2266 (2014-08-01)

Regulatory B cells (B-reg) produce IL-10 and suppress inflammation in both mice and humans, but limited data on the phenotype and function of these cells have precluded detailed assessment of their contribution to host immunity. In this article, we report

Chrysin alleviates testicular dysfunction in adjuvant arthritic rats via suppression of inflammation and apoptosis: comparison with celecoxib.

Hebatallah A Darwish et al.

Toxicology and applied pharmacology, 279(2), 129-140 (2014-06-17)

Long standing rheumatoid arthritis (RA) is associated with testicular dysfunction and subfertility. Few studies have addressed the pathogenesis of testicular injury in RA and its modulation by effective agents. Thus, the current study aimed at evaluating the effects of two

Bracteanolide A abrogates oxidative stress-induced cellular damage and protects against hepatic ischemia and reperfusion injury in rats.

Ting-Yu Chao et al.

Food science & nutrition, 9(9), 4758-4769 (2021-09-18)

Liver diseases, including viral hepatitis, liver cirrhosis, and liver cancer, mostly remain silent until the late stages and pose a continuing threat to millions of people worldwide. Liver transplantation is the most appropriate solution in the case of liver failure

Trichinella spiralis excretory-secretory products protect against polymicrobial sepsis by suppressing MyD88 via mannose receptor.

Linlin Du et al.

BioMed research international, 2014, 898646-898646 (2014-07-24)

Trichinella spiralis (T. spiralis) or its excretory-secretory products (TsES) protect hosts from autoimmune diseases, which depend on inducing host T helper (Th) 2 immune response and inhibiting inflammatory factors. Sepsis is a systemic inflammatory response syndrome (SIRS) evoked by infection.

Activation of toll-like receptor-7 exacerbates lupus nephritis by modulating regulatory T cells.

Li Gong et al.

American journal of nephrology, 40(4), 325-344 (2014-10-25)

Toll-like receptor-7 (TLR7), which recognizes viral single-stranded RNA, can trigger immune complex glomerulonephritis in experimental lupus erythematosus. However, whether it modulates dendritic cells (DCs) phenotype and regulatory T cells (Treg) function is incompletely understood. Splenocytes and bone marrow DCs were

Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice.

Bjarki Johannesson et al.

Disease models & mechanisms, 7(8), 977-985 (2014-07-25)

Allergic contact dermatitis (ACD) is triggered by an aberrant hyperinflammatory immune response to innocuous chemical compounds and ranks as the world's most prevalent occupational skin condition. Although a variety of immune effector cells are activated during ACD, regulatory T (Treg)

Maternal short-chain fructooligosaccharide supplementation influences intestinal immune system maturation in piglets.

Cindy Le Bourgot et al.

PloS one, 9(9), e107508-e107508 (2014-09-23)

Peripartum nutrition is crucial for developing the immune system of neonates. We hypothesized that maternal short-chain fructooligosaccharide (scFOS) supplementation could accelerate the development of intestinal immunity in offspring. Thirty-four sows received a standard or a scFOS supplemented diet (10 g

Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors.

Daniel W Beury et al.

Journal of leukocyte biology, 96(6), 1109-1118 (2014-08-30)

MDSC and macrophages are present in most solid tumors and are important drivers of immune suppression and inflammation. It is established that cross-talk between MDSC and macrophages impacts anti-tumor immunity; however, interactions between tumor cells and MDSC or macrophages are

Early induction of interleukin-10 limits antigen-specific CD4⁺ T cell expansion, function, and secondary recall responses during persistent phagosomal infection.

Abinav Kumar Singh et al.

Infection and immunity, 82(10), 4092-4103 (2014-07-16)

Diverse pathogens have evolved to survive and replicate in the endosomes or phagosomes of the host cells and establish persistent infection. Ehrlichiae are Gram-negative, intracellular bacteria that are transmitted by ticks. Ehrlichiae reside in the endosomes of the host phagocytic

Improvement of spinal non-viral IL-10 gene delivery by D-mannose as a transgene adjuvant to control chronic neuropathic pain.

Ellen C Dengler et al.

Journal of neuroinflammation, 11, 92-92 (2014-06-03)

Peri-spinal subarachnoid (intrathecal; i.t.) injection of non-viral naked plasmid DNA encoding the anti-inflammatory cytokine, IL-10 (pDNA-IL-10) suppresses chronic neuropathic pain in animal models. However, two sequential i.t. pDNA injections are required within a discrete 5 to 72-hour period for prolonged

Maternal sitagliptin treatment attenuates offspring glucose metabolism and intestinal proinflammatory cytokines IL-6 and TNF-α expression in male rats.

Qian Zhang et al.

PeerJ, 8, e10310-e10310 (2020-11-27)

Increasing evidence shows that maternal overnutrition may increase the risk of diabetes in offspring. We hypothesized that maternal sitagliptin intervention may improve glucose intolerance through gut targeting. Female Sprague-Dawley (SD) rats were fed a normal diet (ND) or a high-fat

Helicobacter pylori-induced IL-1β secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the cag pathogenicity island.

Raphaela P Semper et al.

Journal of immunology (Baltimore, Md. : 1950), 193(7), 3566-3576 (2014-08-31)

Infection with the gram-negative bacterium Helicobacter pylori is the most prevalent chronic bacterial infection, affecting ∼50% of the world's population, and is the main risk factor of gastric cancer. The proinflammatory cytokine IL-1β plays a crucial role in the development

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