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Showing 1-30 of 165 results for "S4264" within Papers
Jeong-Tae Yeon et al.
Amino acids, 46(11), 2605-2614 (2014-09-14)
Natural polyamines have numerous biological activities. Several studies have reported their beneficial role in bone metabolism, but their mode of action is not fully understood. Bone diseases such as osteoporosis, which is characterized by impaired bone structure and low bone
Dimitra Hadjipavlou-Litina et al.
Bioorganic & medicinal chemistry, 18(23), 8204-8217 (2010-11-03)
A series of symmetric and asymmetric spermine (SPM) conjugates with all-trans-retinoic acid (ATRA), acitretin (ACI), (E)-3-(trioxsalen-4'-yl)acrylic acid (TRAA) and L-DOPA, amides of ACI, l-DOPA and TRAA with 1-aminobutane, benzylamine, dopamine and 1,12-diaminobutane as well as hybrid conjugates of O,O'-dimethylcaffeic acid
Michael P Greenwood et al.
Endocrinology, 156(8), 2905-2917 (2015-05-12)
The polyamines spermidine and spermine are small cations present in all living cells. In the brain, these cations are particularly abundant in the neurons of the paraventricular (PVN) and supraoptic nuclei (SON) of the hypothalamus, which synthesize the neuropeptide hormones
Tetsuya Hori et al.
Cell reports, 33(7), 108388-108388 (2020-11-19)
CENP-A incorporation is critical for centromere specification and is mediated by the chaperone HJURP. The CENP-A-targeting domain (CATD) of CENP-A specifically binds to HJURP, and this binding is conserved. However, the binding interface of CENP-A-HJURP is yet to be understood.
Donatella Restuccia et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 32(7), 1156-1163 (2015-04-03)
Cocoa contains many compounds such as biogenic amines (BAs), known to influence consumer health. Spermidine, spermidine, putrescine, histamine, tyramine, β-phenylethylamine, cadaverine and serotonine have been found in several cocoa-based products using HPLC with UV detection after derivatisation with dansyl-chloride. Once
Jong-Pyo Kang et al.
Antonie van Leeuwenhoek, 108(3), 619-626 (2015-07-01)
A novel bacterial strain DCY104(T) isolated from soil of a ginseng field in Yeoncheon County, Republic of Korea is described in this study. Cells were short rod-shaped, motile by mean of one polar flagellum, strictly aerobic, Gramreaction negative, oxidase and
Hou-Pan Song et al.
Journal of ethnopharmacology, 159, 23-35 (2014-12-03)
Atractylodes macrocephala Koidz (AMK), a valuable traditional Chinese herbal medicine, has been widely used in clinical practice for treating patients with disorders of the digestive system. AMK has shown noteworthy promoting effect on improving gastrointestinal function and immunity, which might
Fen Hu et al.
PloS one, 9(9), e107217-e107217 (2014-09-26)
The local concentration of extracellular Ca(2+) ([Ca(2+)]o) in bone microenvironment is accumulated during bone remodeling. In the present study we investigated whether elevating [Ca(2+)]o induced store-operated calcium entry (SOCE) in primary rat calvarial osteoblasts and further examined the contribution of
Mounia SidAhmed-Mezi et al.
PloS one, 9(6), e100612-e100612 (2014-06-27)
GABAA receptor (GABAAR) function is maintained by an endogenous phosphorylation mechanism for which the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is the kinase. This phosphorylation is specific to the long intracellular loop I2 of the α1 subunit at two identified serine
Fan Zhang et al.
Proteomics, 15(4), 773-786 (2014-11-21)
Macrophages are heterogeneous and plastic populations that are an essential component of inflammation and host defense. To understand how macrophages respond to cytokine signals, we used 2DE to identify protein profiles in macrophages stimulated with interleukin 4 (M2) and those
Swati Mandal et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(6), 2169-2174 (2013-01-25)
The polyamines, putrescine, spermidine, and spermine, are essential polycations, intimately involved in the regulation of cellular proliferation. Although polyamines exert dynamic effects on the conformation of nucleic acids and macromolecular synthesis in vitro, their specific functions in vivo are poorly
Ekaterina V Filippova et al.
Journal of molecular biology, 427(22), 3538-3553 (2015-09-28)
The spermidine N-acetyltransferase SpeG is a dodecameric enzyme that catalyzes the transfer of an acetyl group from acetyl coenzyme A to polyamines such as spermidine and spermine. SpeG has an allosteric polyamine-binding site and acetylating polyamines regulate their intracellular concentrations.
Gui-Xin Ruan et al.
Molecular pharmaceutics, 11(10), 3322-3329 (2014-04-17)
The incidence of hepatic diseases continuously increases worldwide and causes significant mortality because of inefficient pharmacotherapy. Gene therapy is a new strategy in the treatment of hepatic diseases, but the disadvantages of insufficient retention in the liver and undesirable side
Julia Michaelis et al.
Chemical communications (Cambridge, England), 49(6), 618-620 (2012-12-12)
Most DNA-templated reactions suffer from product inhibition. We explored a DNA-triggered fluorophor transfer reaction and demonstrated that comb-type polylysine-polydextran copolymers increase the turnover in template by promoting strand exchange.
Diego Sanchez et al.
Experimental gerontology, 67, 19-47 (2015-04-15)
A detailed knowledge of the mechanisms underlying brain aging is fundamental to understand its functional decline and the baseline upon which brain pathologies superimpose. Endogenous protective mechanisms must contribute to the adaptability and plasticity still present in the healthy aged
Maria Rosecler Miranda Rossetto et al.
Food chemistry, 188, 218-224 (2015-06-05)
Relationships between endogenous levels of polyamines by thin layer chromatography (TLC) and gas chromatography (GC), nitrate and response to the application of ethylene were established between organic and conventional vegetables (broccoli, collard greens, carrots and beets), both raw and cooked.
T A Swift et al.
Biochimica et biophysica acta, 885(2), 221-230 (1986-02-21)
The effect of the polyamine, spermine, on the interaction of human 125I-labeled FSH with membrane-bound receptors derived from bovine calf testes has been examined. Concentrations of spermine less than 0.01 M resulted in a slight but insignificant (P greater than
Kathryn H Condon et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 3799-3814 (2013-03-01)
Angelman syndrome (AS) is a severe disorder of postnatal brain development caused by neuron-specific loss of the HECT (homologous to E6AP carboxy terminus) domain E3 ubiquitin ligase Ube3a/E6AP. The cellular role of Ube3a remains enigmatic despite recent descriptions of synaptic
Yang Yang et al.
Journal of the American Society of Nephrology : JASN, 29(9), 2310-2325 (2018-07-26)
Autosomal-dominant polycystic kidney disease (ADPKD) is the leading inherited renal disease worldwide. The proproliferative function of macrophages is associated with late-stage cyst enlargement in mice with PKD; however, the way in which macrophages act on cyst-lining epithelial cells (CLECs) has
Gordana Bjelaković et al.
Journal of basic and clinical physiology and pharmacology, 24(1), 67-72 (2013-02-22)
Glucocorticoids (GCs) exert a wide range of anti-inflammatory, immunosuppressive, and antineoplastic activities. The aim of our investigation was to elucidate the effect of dexamethasone, a synthetic GC, on polyamine metabolism in the rat thymus. Male albino Wistar rats, weighing 180-230
Titti Ekegren et al.
Analytical biochemistry, 338(2), 179-185 (2005-03-05)
A high-performance liquid chromatography (HPLC) assay with fluorescence detection was developed for the determination of the polyamines putrescine, spermidine, spermine in samples of human spinal cord, cerebellum, cerebrospinal fluid (CSF), skeletal muscle, and muscle microdialysates without an extensive sample preparation.
Mingzhu Wu et al.
Plant molecular biology, 81(1-2), 27-40 (2012-10-24)
Here, α-Amy2/54 gene expression was used as a molecular probe to investigate the interrelationship among nitric oxide (NO), cyclic GMP (cGMP), and heme oxygenase-1 (HO-1) in GA-treated wheat aleurone layers. The inducible expressions of α-Amy2/54 and α-amylase activity were respectively
Yury Y Vilin et al.
Molecular pharmacology, 84(4), 572-581 (2013-07-28)
Intracellular polyamines are endogenous blockers of inwardly rectifying potassium (Kir) channels and underlie steeply voltage-dependent rectification. Kir channels with strong polyamine sensitivity typically carry a negatively charged side chain at a conserved inner cavity position, although acidic residues at any
Go Kuwata et al.
Journal of cancer research and clinical oncology, 139(6), 925-932 (2013-02-28)
N (1),N (12)-Diacetylspermine (DiAcSpm) is a tumor marker featured by increase in the urine of patients with cancers, including early colorectal cancer, but where and how DiAcSpm is made remains unclear. We aimed to clarify whether colorectal cancer tissues produce
Wen-Hua Chen et al.
Chemistry & biodiversity, 10(3), 385-393 (2013-03-16)
Four dimeric sterol-polyamine conjugates have been synthesized from the homo- and hetero-connection of monomeric sterol-polyamine analogs in a head-to-tail manner. These dimeric conjugates show strong antibacterial activity against a broad spectrum of Gram-positive bacteria, whereas their corresponding activities against Gram-negative
Lipika Goyal et al.
Cancer chemotherapy and pharmacology, 72(6), 1305-1314 (2013-10-15)
N(1),N(11)-diethylnorspermine (DENSPM), a synthetic analog of the naturally occurring polyamine spermine, can induce polyamine depletion and inhibit tumor cell growth. The objectives of this phase I study were to assess the safety, maximum-tolerated dose (MTD), pharmacokinetics, and preliminary antitumor activity
Bidirectional transport of spermine across the inner membrane of liver mitochondria.
A Toninello et al.
Advances in experimental medicine and biology, 250, 491-496 (1988-01-01)
Philippe de Medina et al.
Journal of medicinal chemistry, 52(23), 7765-7777 (2009-10-14)
We describe here the syntheses and the biological properties of new alkylaminooxysterols. Compounds were synthesized through the trans-diaxial aminolysis of 5,6-alpha-epoxysterols with various natural amines including histamine, putrescine, spermidine, or spermine. The regioselective synthesis of these 16 new 5alpha-hydroxyl-6beta-aminoalkylsterols is
Yu Zhu et al.
Molecular pharmaceutics, 12(2), 332-341 (2014-08-26)
Polycations are explored as carriers to deliver therapeutic nucleic acids. Polycations are conventionally pharmacological inert with the sole function of delivering therapeutic cargo. This study reports synthesis of a self-immolative polycation (DSS-BEN) based on a polyamine analogue drug N(1),N(11)-bisethylnorspermine (BENSpm).
Hui Chan Kwak et al.
Biochemical pharmacology, 96(3), 256-266 (2015-06-07)
The present study was aimed to investigate the metabolomics of sulfur amino acids in Zucker diabetic fatty (ZDF) rats, an obese type 2 diabetic animal model. Plasma levels of total cysteine, homocysteine and methionine, but not glutathione (GSH) were markedly
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