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Showing 1-30 of 2597 results for "S5442" within Papers
T G Cotter et al.
Diabetes research and clinical practice, 106(3), e56-e59 (2014-12-03)
We sought to determine the attainment of targets for glycaemic control and vascular risk reduction in an Irish cohort of T1DM adults. Of 797 patients (53% male, mean age 40.3 ± 14.8 years, HbA1c 8.5 ± 1.6% (69.6 ± 17.8
Saeed Samarghandian et al.
BioMed research international, 2014, 920857-920857 (2014-08-13)
Diabetic encephalopathy is one of the severe complications in patients with diabetes mellitus. Findings indicate that saffron extract has antioxidant properties but its underlying beneficial effects on diabetic encephalopathy were unclear. In the present study, the protective activities of saffron
Fred K Tabung et al.
Annals of epidemiology, 25(6), 398-405 (2015-04-23)
Many dietary factors have either proinflammatory or anti-inflammatory properties. We previously developed a dietary inflammatory index (DII) to assess the inflammatory potential of diet. In this study, we conducted a construct validation of the DII based on data from a
José M A Wijnands et al.
Journal of hypertension, 33(8), 1642-1650 (2015-07-03)
Arterial stiffness may be a mechanism to explain the association between uric acid and cardiovascular disease. We aimed to analyse associations between serum uric acid and regional and local arterial stiffness, and assess potential differences related to sex and glucose
Nitin Shivappa et al.
Cancer causes & control : CCC, 26(10), 1439-1447 (2015-07-26)
Diet and inflammation have been suggested to be important risk factors for esophageal squamous cell cancer (ESCC). In this study, we examined the association between the dietary inflammatory index (DII) and ESCC in a case-control study conducted between 1992 and
P Lestaevel et al.
Journal of molecular neuroscience : MN, 53(3), 469-479 (2013-06-12)
Alzheimer's disease is associated with genetic risk factors, of which the apolipoprotein E (ApoE) is the most prevalent, and is affected by environmental factors that include education early in life and exposure to metals. The industrial and military use of
Chihiro Okuma et al.
Journal of pharmacological sciences, 128(3), 150-157 (2015-07-29)
Monoacyglycerol acyltransferases (MGATs) are known to play important roles in intestinal TG absorption. In contrast, the role of MGATs in the liver is still unclear. We investigated the effects of JTP-103237, a novel MGAT inhibitor, on hepatic MGAT activity and
Tsubasa Miyoshi et al.
Biochimica et biophysica acta, 1838(12), 3069-3077 (2014-08-26)
We examined the volumetric behavior of the dipalmitoylphosphatidylcholine (DPPC)/cholesterol binary bilayer system with high accuracy and more cholesterol concentrations to reveal the detailed molecular states in the liquid-disordered (Ld) phase, the liquid-ordered (Lo) phase and the gel phase. We measured
Zhiping Hu et al.
Physical chemistry chemical physics : PCCP, 17(35), 22711-22720 (2015-08-11)
The aggregation and fibril formation of amyloid β(Aβ) peptides onto a ganglioside-GM1-containing lipid membrane is a cause of neurodegenerative diseases. The mechanism of the initial binding and the conformational changes of Aβ on the membrane should be clarified. Fluorescence microscopy
Gabriel F Ballester-Lozano et al.
The British journal of nutrition, 114(5), 713-726 (2015-07-30)
Seven isoproteic and isolipidic semi-purified diets were formulated to assess specific nutrient deficiencies in sulphur amino acids (SAA), n-3 long-chain PUFA (n-3 LC-PUFA), phospholipids (PL), P, minerals (Min) and vitamins (Vit). The control diet (CTRL) contained these essential nutrients in
N P Mikaelyan et al.
Bulletin of experimental biology and medicine, 159(2), 197-200 (2015-06-23)
Considerable changes in serum lipids and lipoprotein profiles associated with hypertriglyceridemia, hypercholesterolemia, increased VLDL and LDL concentrations, and reduced HDL level occur at the early stages of streptozotocin-induced diabetes (day 7) in rats. The level of saturated palmitic fatty acid
T Pina et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 29(10), 1995-2001 (2015-04-01)
Altered secretion patterns of proinflammatory adipokines may influence the increased risk of cardiovascular mortality observed in patients with chronic inflammatory diseases. To determine whether two adipokines, leptin and resistin, correlate with metabolic syndrome features and disease severity in psoriatic patients
Soichiro Murata et al.
International journal of molecular sciences, 16(6), 12051-12063 (2015-05-30)
Hepatocyte-specific Phosphatase and tensin homolog (Pten)-knockout (KO) mice exhibit hepatic lesions analogous to non-alcoholic steatohepatitis (NASH). 1,8-cineole is a monoterpene oxide and it has several biological effects including hepatoprotective effects. In this study we revealed that 1,8-cineole ameliorates NASH of
Michal Holčapek et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 990, 52-63 (2015-04-10)
Differences among lipidomic profiles of healthy volunteers, obese people and three groups of cardiovascular disease (CVD) patients are investigated with the goal to differentiate individual groups based on the multivariate data analysis (MDA) of lipidomic data from plasma, erythrocytes and
Alexandra Bédard et al.
Nutrients, 7(5), 3705-3723 (2015-05-20)
Sex differences have been previously highlighted in the cardioprotective effects of the Mediterranean diet (MedDiet). The objective of this study was to investigate whether sex differences also exist with regard to LDL particle size distribution and oxidation. Participants were 37
Elisabetta Albi et al.
PloS one, 9(5), e98250-e98250 (2014-05-29)
Maintaining a good health requires the maintenance of a body homeostasis which largely depends on correct functioning of thyroid gland. The cells of the thyroid tissue are strongly sensitive to hypogravity, as already proven in mice after returning to the
Bieong-Kil Kim et al.
International journal of molecular sciences, 15(5), 7293-7312 (2014-05-03)
Cationic liposomes are broadly used as non-viral vectors to deliver genetic materials that can be used to treat various diseases including cancer. To circumvent problems associated with cationic liposome-mediated delivery systems such as low transfection efficiency and serum-induced inhibition, cholesterol-based
Sophie Stukas et al.
Journal of lipid research, 55(8), 1721-1729 (2014-06-22)
A key step in plasma HDL maturation from discoidal to spherical particles is the esterification of cholesterol to cholesteryl ester, which is catalyzed by LCAT. HDL-like lipoproteins in cerebrospinal fluid (CSF) are also spherical, whereas nascent lipoprotein particles secreted from
Itandehui Castro-Quezada et al.
European journal of nutrition, 54(4), 523-534 (2014-07-10)
To examine the association between dietary glycaemic index (GI) and dietary glycaemic load (GL) with cardiovascular disease (CVD) risk factors in a rural elderly population. A cross-sectional study was conducted in 343 subjects (60-74 years) residing in a Spanish rural
R Stöhr et al.
Scientific reports, 5, 9023-9023 (2015-03-18)
Atherosclerosis is a chronic inflammatory disease characterized by the infiltration of pro-inflammatory macrophages into a lipid-laden plaque. ITCH is an E3 ubiquitin ligase that has been shown to polarize macrophages to an anti-inflammatory phenotype. We therefore investigated the effect of
Christiana A Georgiou et al.
Food chemistry, 145, 918-926 (2013-10-17)
In recent years, cholesterol oxidation products (COPs) have drawn scientific interest, particularly due to their implications on human health. A big number of these compounds have been demonstrated to be cytotoxic, mutagenic, and carcinogenic. The main source of COPs is
Prue Cormie et al.
BJU international, 115(2), 256-266 (2014-01-29)
To determine if supervised exercise minimises treatment toxicity in patients with prostate cancer initiating androgen-deprivation therapy (ADT). This is the first study to date that has investigated the potential role of exercise in preventing ADT toxicity rather than recovering from
Tomokazu Sumida et al.
Nature communications, 6, 6241-6241 (2015-02-27)
Hypertension induces structural remodelling of arteries, which leads to arteriosclerosis and end-organ damage. Hyperplasia of vascular smooth muscle cells (VSMCs) and infiltration of immune cells are the hallmark of hypertensive arterial remodelling. However, the precise molecular mechanisms of arterial remodelling
Hidetaka Hamasaki et al.
Journal of diabetes research, 2015, 526201-526201 (2015-06-13)
To investigate the association between daily physical activity and metabolic risk factors in Japanese adults with prediabetes or untreated early type 2 diabetes (T2D). Daily physical activity level was measured using a triaxial accelerometer. We assessed correlations between physical activity
Marilia C O Sprandel et al.
Cardiovascular diabetology, 14, 107-107 (2015-08-14)
We previously showed that unesterified-cholesterol transfer to high-density lipoprotein (HDL), a crucial step in cholesterol esterification and role in reverse cholesterol transport, was diminished in non-diabetic patients with coronary artery disease (CAD). The aim was to investigate whether, in patients
Emina Vorkapic et al.
Atherosclerosis, 241(2), 561-568 (2015-06-24)
Abdominal aortic aneurysm (AAA) is characterized by inflammation, loss of smooth muscle cells (SMCs), and degradation of the extracellular matrix in the vessel wall. Innate immune receptors such as Toll-like receptors (TLRs) were recently shown to regulate immunological processes leading
Swathi Seshadri et al.
Acta ophthalmologica, 93(4), e266-e274 (2014-12-10)
To investigate the relationship between retinal microvascular reactivity, circulatory markers for CVD risk and systemic antioxidative defence capacity in healthy middle-aged individuals with low to moderate risk of CVD. Retinal vascular reactivity to flickering light was assessed in 102 healthy
Dominique Hansen et al.
Experimental physiology, 100(7), 818-828 (2015-05-13)
What is the central question of this study? It remains uncertain whether significant fat-free mass wasting occurs early after coronary artery bypass graft surgery, and the aetiology of this wasting in these particular conditions is unexplored. What is the main
Ekaterina S Menchinskaya et al.
Natural product communications, 8(10), 1377-1380 (2013-12-21)
In non-cytotoxic concentrations, frondoside A (1) from the sea cucumber Cucumaria okhotensis and cucumarioside A2-2 (2) from C. japonica, as well as their complexes with cholesterol block the activity of membrane transport P-glycoprotein in cells of the ascite form of
Eriks Smagris et al.
Hepatology (Baltimore, Md.), 61(1), 108-118 (2014-06-12)
A sequence polymorphism (rs738409, I148M) in patatin-like phospholipid domain containing protein 3 (PNPLA3) is strongly associated with nonalcoholic fatty liver disease (NAFLD), but the mechanistic basis for this association remains enigmatic. Neither ablation nor overexpression of wild-type PNPLA3 affects liver
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