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Showing 1-30 of 441 results for "S8750" within Papers
Narcy Arizmendi et al.
Respiratory research, 15, 71-71 (2014-06-28)
Pulmonary fibrotic diseases induce significant morbidity and mortality, for which there are limited therapeutic options available. Rac2, a ras-related guanosine triphosphatase expressed mainly in hematopoietic cells, is a crucial molecule regulating a diversity of mast cell, macrophage, and neutrophil functions.
Martijs J Jonker et al.
Nucleic acids research, 42(11), e94-e94 (2014-04-29)
Structural variations in genomes are commonly studied by (micro)array-based comparative genomic hybridization. The data analysis methods to infer copy number variation in model organisms (human, mouse) are established. In principle, the procedures are based on signal ratios between test and
Zhongyan Lu et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 308(4), R283-R293 (2014-12-19)
Currently, the mechanism(s) responsible for the regulation of urea transporter B (UT-B) expression levels in the epithelium of the rumen remain unclear. We hypothesized that rumen fermentation products affect ruminal UT-B expression. Therefore, the effects of short-chain fatty acids (SCFA)
Jennifer Vandooren et al.
The Biochemical journal, 465(2), 259-270 (2014-11-02)
Gelatinase B/matrix metalloproteinase-9 (MMP-9) (EC cleaves many substrates and is produced by most cell types as a zymogen, proMMP-9, in complex with the tissue inhibitor of metalloproteinases-1 (TIMP-1). Natural proMMP-9 occurs as monomers, homomultimers and heterocomplexes, but our knowledge about
Laure Thibaudeau et al.
Disease models & mechanisms, 7(2), 299-309 (2014-04-10)
The skeleton is a preferred homing site for breast cancer metastasis. To date, treatment options for patients with bone metastases are mostly palliative and the disease is still incurable. Indeed, key mechanisms involved in breast cancer osteotropism are still only
Minsuk Kong et al.
Applied and environmental microbiology, 81(7), 2274-2283 (2015-01-18)
Bacillus cereus is an opportunistic human pathogen responsible for food poisoning and other, nongastrointestinal infections. Due to the emergence of multidrug-resistant B. cereus strains, the demand for alternative therapeutic options is increasing. To address these problems, we isolated and characterized
Christian Hinderer et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(12), 2018-2027 (2014-07-17)
Enzyme replacement therapy has revolutionized the treatment of the somatic manifestations of lysosomal storage diseases (LSD), although it has been ineffective in treating central nervous system (CNS) manifestations of these disorders. The development of neurotrophic vectors based on novel serotypes
Shi-Jun Dong et al.
The international journal of biochemistry & cell biology, 68, 33-41 (2015-08-19)
During the industrial bioethanol fermentation, Saccharomyces cerevisiae cells are often stressed by bacterial contaminants, especially lactic acid bacteria. Generally, lactic acid bacteria contamination can inhibit S. cerevisiae cell growth through secreting lactic acid and competing with yeast cells for micronutrients
Sun-Ah Kim et al.
Archives of pharmacal research, 38(2), 239-248 (2014-12-17)
5-FU is an anticancer drug that is widely used to treat cancers, including colorectal cancer (CRC); however, chemoresistance to 5-FU remains an important problem to be resolved. The role of microRNAs (miRs) in chemosensitivity has recently been studied in the
Brian R Fritz et al.
Nucleic acids research, 42(10), 6774-6785 (2014-05-06)
In vitro ribosome construction could enable studies of ribosome assembly and function, provide a route toward constructing minimal cells for synthetic biology, and permit the construction of ribosome variants with new functions. Toward these long-term goals, we recently reported on
Xia Gao et al.
Biochimica et biophysica acta, 1851(2), 152-162 (2014-12-03)
Mice lacking phosphatidylethanolamine N-methyltransferase (PEMT, Pemt(-/-) mice) are resistant to high-fat diet (HFD)-induced obesity (DIO) but develop non-alcoholic steatohepatitis. PEMT expression is strongly induced during differentiation of 3T3-L1 adipocytes. Hence, we hypothesized that white adipose tissue (WAT) might be a
Armando Díaz-Valle et al.
Journal of virological methods, 225, 23-29 (2015-09-08)
Obtaining pure and soluble viral capsid proteins (CPs) has been a major challenge in the fields of science and technology in recent decades. In many cases, the CPs can self-assemble in the absence of a viral genome, resulting in non-infectious
Yasutada Akiba et al.
The Journal of physiology, 593(3), 585-599 (2014-11-30)
Luminal lipid in the duodenum modulates gastroduodenal functions via the release of gut hormones and mediators such as cholecystokinin and 5-HT. The effects of luminal short-chain fatty acids (SCFAs) in the foregut are unknown. Free fatty acid receptors (FFARs) for
Mohamed Abdel-Tawab Korany et al.
Journal of chromatographic science, 52(8), 837-847 (2013-09-06)
A novel high performance liquid chromatographic (HPLC) method with a pre-column derivatization reaction has been developed and validated. The method was used for the determination of the aminoglycoside antibiotic amikacin sulphate (AMK) in the presence of its synthetic precursor kanamycin
Iain M McIntyre et al.
Journal of analytical toxicology, 39(2), 152-155 (2014-12-18)
A 24-year-old man whose medical history was significant for alcohol abuse and depression was found unresponsive in bed. He had several prior suicide attempts with 'pills' and had also been hospitalized for an accidental overdose on a previous occasion. Autopsy
Iain M McIntyre et al.
Journal of analytical toxicology, 39(2), 156-159 (2014-11-29)
A 20-year-old man, a college student, became unresponsive in front of his girlfriend. He was known to consume alcohol and take an unknown drug at some point while in attendance at a local music festival earlier in the day/evening. Upon
Marianna Villano et al.
Bioelectrochemistry (Amsterdam, Netherlands), 107, 1-6 (2015-09-08)
The effect of the set anode potential (between + 200 mV and - 200 mV vs. SHE, standard hydrogen electrode) on the performance and distribution of internal potential losses has been analyzed in a continuous-flow methane-producing microbial electrolysis cell (MEC).Both
Md Musfiqur Rahman et al.
Food chemistry, 174, 248-255 (2014-12-23)
A simultaneous method was developed to analyse thiamethoxam and its metabolite clothianidin in Swiss chard using tandem mass spectrometry (in the positive electrospray ionisation mode using multiple reaction monitoring mode) to estimate the dissipation pattern and the pre-harvest residue limit
André Valle de Bairros et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 975, 24-33 (2014-12-03)
In this study, it is shown a method for the determination of benzodiazepines and their main metabolites in urine samples by hollow-fiber liquid-phase microextraction (LPME) in the three-phase mode. Initially, the hydrolysis step was performed using 100 μL of sodium
E Espino-Pérez et al.
Carbohydrate polymers, 135, 256-266 (2015-10-11)
Cellulose nanocrystals (CNC) and starch nanocrystals (SNC) were grafted by ozone-initiated free-radical polymerisation of styrene in a heterogeneous medium. Surface functionalisation was confirmed by infrared spectroscopy, contact angle measurements, and thermogravimetric and elemental analysis. X-ray diffraction and scanning electron microscopy
Gözde Türköz Bakırcı et al.
Food chemistry, 160, 379-392 (2014-05-07)
The purpose of this study was to investigate pesticide residues in fruits and vegetables from the Aegean region of Turkey. A total of 1423 samples of fresh fruit and vegetables were collected from 2010 to 2012. The samples were analysed
Dinesh Koju et al.
Journal of microbiology and biotechnology, 22(8), 1127-1132 (2012-06-21)
Nargenicin A1 is a 28-membered polyketide macrolide, with antibacterial activity against methicillin-resistant Staphylococcus aureus, produced by Nocardia sp. CS682. In this study, the production of nargenicin A1 was improved by enhancing the supply of different biosynthetic precursors. In Nocardia sp.
Qiong Jin et al.
Bioresource technology, 117, 148-154 (2012-05-23)
Dietzia natronolimnaea JQ-AN was isolated from industrial wastewater containing aniline. Under aerobic conditions, the JQ-AN strain degraded 87% of the aniline in a 300 mg L(-1) aniline solution after 120 h of shake flask incubation in a medium containing sodium
S Srinivasa et al.
The British journal of surgery, 100(1), 66-74 (2012-11-08)
Goal-directed fluid therapy (GDFT) has been compared with liberal fluid administration in non-optimized perioperative settings. It is not known whether GDFT is of value within an enhanced recovery protocol incorporating fluid restriction. This study evaluated GDFT under these circumstances in
Qiong Dai et al.
ACS nano, 9(3), 2876-2885 (2015-02-26)
Engineered particles adsorb biomolecules (e.g., proteins) when introduced in a biological medium to form a layer called a "corona". Coronas, in particular the protein corona, play an important role in determining the surface properties of particles and their targeting abilities.
Sascha Eichendorff et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 17(1), 87-93 (2014-07-24)
The hemoglobin scavenger receptor CD163 is exclusively expressed on monocytes and tissue macrophages, also at sites of inflammation. We examined whether gallium-68 (Ga-68)-labeled anti-CD163-antibody can detect the receptor in vivo. We radiolabeled anti-CD163 antibody with Ga-68 and evaluated stability and
Estrid Hein et al.
Molecular immunology, 63(2), 209-214 (2014-07-30)
The complement system plays a pathophysiological role in systemic lupus erythematosus (SLE). This study aims to investigate whether an association exists between the ficolins that are part of the lectin complement pathway and SLE. EDTA plasma samples from 68 Danish
Sara A Murray et al.
Journal of immunology (Baltimore, Md. : 1950), 194(5), 2268-2279 (2015-02-04)
The costimulatory molecule CD40 enhances immunity through several distinct roles in T cell activation and T cell interaction with other immune cells. In a mouse model of immunity to liver stage Plasmodium infection, CD40 was critical for the full maturation
Adelina B Batista et al.
PloS one, 9(10), e111427-e111427 (2014-10-28)
Mo-CBP3 is a chitin-binding protein purified from Moringa oleifera Lam. seeds that displays inhibitory activity against phytopathogenic fungi. This study investigated the structural properties and the antifungal mode of action of this protein. To this end, circular dichroism spectroscopy, antifungal
Annika I Ostermann et al.
Analytical and bioanalytical chemistry, 407(5), 1403-1414 (2014-12-30)
Oxylipins are potent lipid mediators. For the evaluation of their biological roles, several LC-MS based methods have been developed. While these methods are similar, the described sample preparation procedures for the extraction of oxylipins differ considerably. In order to deduce
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