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Showing 1-29 of 29 results for "SAB4200176" within Papers
Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells
Rodriguez HMA, et al.
Journal of Cellular Physiology, 234(1), 692-708 (2019)
Esophageal squamous cell carcinomas with distinct invasive depth show different gene expression profiles associated with lymph node metastasis
Sato T, et al.
International Journal of Oncology, 28(5), 1043-1055 (2006)
Ján Vančo et al.
International journal of molecular sciences, 22(14) (2021-07-25)
A series of new heteroleptic copper(II) complexes of the composition [Cu(L)(bpy)]NO3·2MeOH (1), [Cu(L)(dimebpy)]NO3·2H2O (2), [Cu(L)(phen)]NO3·2MeOH (3), [Cu(L)(bphen)]NO3·MeOH (4), [Cu(L)(dppz)]NO3·MeOH (5) was prepared, where HL = 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-ene-1-yl)-4H,8H-benzo[1,2-b:3,4-b']dipyran-4-one, (pomiferin) and bpy = 2,2'-bipyridine, dimebpy = 4,4'-dimethyl-2,2'-bipyridine, phen = 1,10-phenanthroline, bphen = 4,7-diphenyl-1,10-phenanthroline
Alexey I Goncharov et al.
Biochemistry. Biokhimiia, 86(11), 1446-1460 (2021-12-16)
Progesterone and its synthetic analogues act on cells through different types of receptors, affecting proliferation and apoptosis. These compounds exert their effect through the nuclear receptors and the insufficiently studied membrane progesterone receptors (mPRs) belonging to the progestin and adiponectin
Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-
Daniele S, et al.
Cellular Signalling, 27(8), 1609-1629 (2015)
María A Rodríguez-Hernández et al.
Journal of cellular physiology, 234(1), 692-708 (2018-08-23)
Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) stress, c-Jun-N-terminal kinase (JNK), Akt, and 5'AMP-activated protein kinase (AMPK)
Kristina A Sharlo et al.
Biomolecules, 13(9) (2023-09-28)
Skeletal muscle abnormalities and atrophy during unloading are accompanied by the accumulation of excess calcium in the sarcoplasm. We hypothesized that calcium accumulation may occur, among other mechanisms, due to the inhibition of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity. Consequently, the
Trazodone regulates neurotrophic/growth factors, mitogen-activated protein kinases and lactate release in human primary astrocytes
Daniele S, et al.
Journal of Neuroinflammation, 12(1), 1-24 (2015)
Jie Liu et al.
Molecular medicine reports, 24(3) (2021-07-20)
Previous studies have identified microRNA (miRNA/miR)‑3613‑3p as a heat stress (HS)‑related miRNA in endothelial cells that can lead to apoptosis. However, the mechanism underlying the miR‑3613‑3p‑mediated apoptosis of HS‑exposed endothelial cells remains unclear. In the present study, western blot analysis
Simona Daniele et al.
Cellular signalling, 27(8), 1609-1629 (2015-04-26)
Growing evidence suggests that alterations of the inflammatory/immune system contribute to the pathogenesis of major depression and that inflammatory processes may influence the antidepressant treatment response. Depressed patients exhibit increased levels of inflammatory markers in both the periphery and brain
Simona Daniele et al.
Journal of neuroinflammation, 12, 225-225 (2015-12-03)
In the central nervous system, glial cells provide metabolic and trophic support to neurons and respond to protracted stress and insults by up-regulating inflammatory processes. Reactive astrocytes and microglia are associated with the pathophysiology of neuronal injury, neurodegenerative diseases and
Xiuli Zhang et al.
Kidney & blood pressure research, 43(2), 500-512 (2018-04-09)
Evidence from our and other groups has demonstrated that zinc transporter 7 in SLC30 family (ZnT7) inhibited epithelial-to-mesenchymal transition (EMT) and apoptosis in rat peritoneal mesothelial cells (RPMCs) under high glucose (HG) concentration. In the present study, we investigated the
Kristina A Sharlo et al.
Current issues in molecular biology, 45(7), 5613-5630 (2023-07-28)
Skeletal muscle disuse leads to pathological muscle activity as well as to slow-to-fast fiber-type transformation. Fast-type fibers are more fatigable than slow-type, so this transformation leads to a decline in muscle function. Prochlorperazine injections previously were shown to attenuate autonomous
The Role of c-Jun N-Terminal Kinase (JNK) in Retinal Degeneration and Vision Loss
Kim BJ, et al.
Advances in Experimental Medicine and Biology, Adv(Exp), Med-Med (2018)
Xuehui Yu et al.
American journal of cancer research, 12(10), 4825-4839 (2022-11-17)
Glioblastoma (GBM) is the most frequently observed and aggressive type of high-grade malignant glioma. Temozolomide (TMZ) is the primary agent for GBM treatment. However, TMZ resistance remains a major challenge. In this study, we report that MDK is overexpressed in
Nargis Nasrin et al.
PloS one, 4(12), e8414-e8414 (2009-12-23)
SIRT1 is a NAD-dependent deacetylase that regulates a variety of pathways including the stress protection pathway. SIRT1 deacetylates a number of protein substrates, including histones, FOXOs, PGC-1alpha, and p53, leading to cellular protection. We identified a functional interaction between cJUN
Edward Kabara et al.
Frontiers in microbiology, 3, 215-215 (2012-07-27)
Mycobacterium avium subspecies paratuberculosis (MAP) is able to survive intracellularly in macrophages by preventing normal phagosome maturation processes utilized to destroy bacteria. Infected macrophages often undergo apoptotic cell death to efficiently present bacterial antigens to the host adaptive immune system
Jing Liu et al.
Cell research, 15(1), 36-42 (2005-02-03)
JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-kB activation, prolonged JNK activation contributes to TNF-a induced apoptosis. JNK is also essential for UV induced apoptosis. However, recent studies reveal
Feng Dong et al.
Canadian journal of physiology and pharmacology, 96(1), 1-7 (2017-02-09)
Epithelial-to-mesenchymal transition is a cellular process associated with cancer invasion and metastasis. However, the antimetastatic effects of chimaphilin remain elusive. In this study, we attempted to investigate the potential use of chimaphilin as an inhibitor of TGF-β1-induced epithelial-to-mesenchymal transition in
Yongjie Wei et al.
Molecular cell, 30(6), 678-688 (2008-06-24)
Starvation induces autophagy to preserve cellular homeostasis in virtually all eukaryotic organisms. However, the mechanisms by which starvation induces autophagy are not completely understood. In mammalian cells, the antiapoptotic protein, Bcl-2, binds to Beclin 1 during nonstarvation conditions and inhibits
HSP70 Facilitates Memory Consolidation of Fear Conditioning through MAPK Pathway in the Hippocampus
Porto RR, et al.
Neuroscience, 375, 108-118 (2018)
Jiao Zheng et al.
Cancer management and research, 11, 5231-5242 (2019-06-27)
Background: Hepatocellular carcinoma (HCC) is a particularly prevalent type of liver cancer and is one of the deadliest malignancies in Asia. Tangeretin is a biological compound extracted from traditional Chinese herbs and has been shown to have potential antitumour properties;
Chengliang Yuan et al.
Journal of biochemical and molecular toxicology, 36(1), e22943-e22943 (2021-11-02)
Eriocitrin, a lemons flavanone, exhibits several biological properties, antiproliferative, and proapoptotic effects. However, its molecular mechanical action is not entirely clarified. Oxidative stress causes abnormal stimulation of signal transducer and activator of transcription 3 (STAT3) and c-Jun NH2-terminal kinase (JNK), p38
Veronika Leláková et al.
Journal of ethnopharmacology, 263, 113147-113147 (2020-08-01)
Macaranga Thou. (Euphorbiaceae) is a large genus that comprises over 300 species distributed between Western Africa and the islands of the South Pacific. Plants of this genus have a long-standing history of use in traditional medicine for different purposes, including
Yanfang Li et al.
Cardiovascular engineering and technology, 11(2), 219-227 (2020-01-10)
Recent studies have demonstrated that miRNAs play a vital role in regulating myocardial ischemia/reperfusion injury (MIRI). MiR-217 has been proven to be implicated in cardiac diseases such as chronic heart failure and cardiac myxoma. However, the role of miR-217 in
B Dérijard et al.
Cell, 76(6), 1025-1037 (1994-03-25)
The ultraviolet (UV) response of mammalian cells is characterized by a rapid and selective increase in gene expression mediated by AP-1 and NF-kappa B. The effect on AP-1 transcriptional activity results, in part, from enhanced phosphorylation of the c-Jun NH2-terminal
JNK Signaling in Apoptosis
Dhanasekaran DN, et al.
Oncogene, 27(48), 6245-6245 (2008)
Nan-Shan Chang et al.
The Journal of biological chemistry, 278(11), 9195-9202 (2003-01-07)
Transient activation of c-Jun N-terminal kinase (JNK) promotes cell survival, whereas persistent JNK activation induces apoptosis. Bovine testicular hyaluronidase PH-20 activates JNK1 and protects L929 fibroblasts from staurosporine-mediated cell death. PH-20 also induces the expression of a p53-interacting WW domain-containing
Patrick Robison et al.
Skeletal muscle, 4(1), 1-1 (2014-01-05)
The NFATc transcription factor family is responsible for coupling cytoplasmic calcium signals to transcription programs in a wide variety of cell types. In skeletal muscle, these transcription factors control the fiber type in response to muscle activity. This excitation-transcription (E-T)
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