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Showing 1-10 of 10 results for "SAB4200697" within Papers
Chang Chen et al.
Metabolic brain disease, 34(1), 203-212 (2018-11-15)
Parkinson's disease (PD) is a common chronic neurodegenerative disease and greatly affects the quality of PD patients' life. Current symptomatic treatment of PD is limited. There are no effective treatment and drugs that could radically cure PD. Increasing experimental evidence
Chun Chen et al.
NPJ Parkinson's disease, 7(1), 39-39 (2021-05-14)
Here we report the application of a mass spectrometry-based technology, imaging mass cytometry, to perform in-depth proteomic profiling of mitochondrial complexes in single neurons, using metal-conjugated antibodies to label post-mortem human midbrain sections. Mitochondrial dysfunction, particularly deficiency in complex I
Guoxue Zhu et al.
Aging, 13(15), 19510-19528 (2021-08-03)
Parkinson's disease (PD), the typical neurodegenerative disease, is characterized by the progressive loss of dopaminergic neurons in the substantia nigra (SN). However, no therapeutic agent used currently could slow down neuronal cell loss so as to decelerate or halt the
TYROSINE HYDROXYLASE. THE INITIAL STEP IN NOREPINEPHRINE BIOSYNTHESIS.
NAGATSU T, et al.
The Journal of Biological Chemistry, 2910-2917 (1964)
The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease.
Tekin I, et al.
Parkinsonism & Related Disorders, 86-90 (2016)
S P Craig et al.
Cytogenetics and cell genetics, 42(1-2), 29-32 (1986-01-01)
Phenylalanine hydroxylase (PAH) and tyrosine hydroxylase (TH) are consecutive enzymes in the metabolic pathway leading to the production of catecholamine neurotransmitters. A comparison of recently available sequence data of these enzymes in the rat indicates about 70% homology in the
Role of N-terminus of tyrosine hydroxylase in the biosynthesis of catecholamines.
Nakashima A, et al.
Journal of neural transmission (Vienna, Austria : 1996), 116, 1355-1362 (2009)
Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40.
Haycock JW
The Journal of Biological Chemistry, 265, 11682-11691 (1990)
Lili Tang et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 9838295-9838295 (2020-07-14)
This study aimed to explore the protective effects of Wenshen-Yanggan decoction on dopaminergic (DA) neuron injury in a rotenone-induced mouse model with chronic Parkinson's disease (PD) and explore its mechanism of action. Ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used
Chun Chen et al.
NPJ Parkinson's disease, 9(1), 120-120 (2023-08-09)
Mitochondrial dysfunction has been suggested to contribute to Parkinson's disease pathogenesis, though an understanding of the extent or exact mechanism of this contribution remains elusive. This has been complicated by challenging nature of pathway-based analysis and an inability simultaneously study
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