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Showing 1-30 of 61 results for "SCC109" within Papers
Xinyong Cai et al.
Molecular medicine reports, 22(6), 4579-4588 (2020-11-12)
FGD5 antisense RNA 1 (FGD5‑AS1) is a long non‑coding RNA in acute myocardial infarction (AMI), which is primarily caused by myocardial ischemia‑hypoxia. Retinoid acid receptor‑related orphan receptor α (RORA) is a key protector in maintaining heart function. However, the roles of FGD5‑AS1 and RORA
Qiulian Zhou et al.
EBioMedicine, 85, 104274-104274 (2022-10-02)
Homeodomain-Interacting Protein Kinase 2 (HIPK2) has been reported to maintain basal cardiac function, however, its role in pathological cardiac remodeling remains unclear. HIPK2 inhibitors (tBID and PKI1H) treated mice and two lines of HIPK2-/- mice were subjected to transverse aortic
Matthew Alonzo et al.
Progress in biomaterials, 9(3), 125-137 (2020-09-27)
Hydrogels are a class of biomaterials used for a wide range of biomedical applications, including as a three-dimensional (3D) scaffold for cell culture that mimics the extracellular matrix (ECM) of native tissues. To understand the role of the ECM in
John Henderson et al.
Frontiers in cardiovascular medicine, 8, 737826-737826 (2021-09-07)
Doxorubicin (DOX, an anthracycline) is a widely used chemotherapy agent against various forms of cancer; however, it is also known to induce dose-dependent cardiotoxicity leading to adverse complications. Investigating the underlying molecular mechanisms and strategies to limit DOX-induced cardiotoxicity might
Bruno Moukette et al.
Cell death discovery, 8(1), 504-504 (2022-12-31)
The β1-adrenergic receptor (β1AR) is found primarily in hearts (mainly in cardiomyocytes [CMs]) and β-arrestin-mediated β1AR signaling elicits cardioprotection through CM survival. We showed that microRNA-150 (miR-150) is upregulated by β-arrestin-mediated β1AR signaling and that CM miR-150 inhibits maladaptive remodeling
FTY720-P, a Biased S1PR Ligand, Increases Mitochondrial Function through STAT3 Activation in Cardiac Cells.
Mu??oz, et al.
International Journal of Molecular Sciences, 24 (2023)
Mark Li et al.
Stem cells translational medicine, 10(3), 385-397 (2020-10-25)
To optimize the regenerative proficiency of stem cells, a cardiopoietic protein-based cocktail consisting of multiple growth factors has been developed and advanced into clinical trials for treatment of ischemic heart failure. Streamlining the inductors of cardiopoiesis would address the resource
Tomoya Sakamoto et al.
Nature communications, 13(1), 1991-1991 (2022-04-15)
Estrogen-related receptors (ERR) α and γ were shown recently to serve as regulators of cardiac maturation, yet the underlying mechanisms have not been delineated. Herein, we find that ERR signaling is necessary for induction of genes involved in mitochondrial and
Alexis Bouin et al.
Journal of virology, 97(1), e0142622-e0142622 (2022-12-09)
Group B enteroviruses, including coxsackievirus B3 (CVB3), can persistently infect cardiac tissue and cause dilated cardiomyopathy. Persistence is linked to 5' terminal deletions of viral genomic RNAs that have been detected together with minor populations of full-length genomes in human
Xiangyang Wu et al.
Experimental and therapeutic medicine, 18(4), 3172-3176 (2019-10-02)
MicroRNA-663 (miRNA-663) regulates the expression of transforming growth factor β1 (TGF-β1), which participates in the pathogenesis of myocardial fibrosis. Therefore, microRNA-663 may also serve a role in myocardial fibrosis. The present study aimed to determine whether miRNA-663 participates in myocardial
Da-Yuan Chen et al.
iScience, 26(5), 106634-106634 (2023-04-25)
A simple and robust cell culture system is essential for generating authentic SARS-CoV-2 stocks for evaluation of viral pathogenicity, screening of antiviral compounds, and preparation of inactivated vaccines. Evidence suggests that Vero E6, a cell line commonly used in the
Lucia Scisciola et al.
Cardiovascular diabetology, 22(1), 24-24 (2023-02-04)
Sodium-glucose co-transporters (SGLT) inhibitors (SGLT2i) showed many beneficial effects at the cardiovascular level. Several mechanisms of action have been identified. However, no data on their capability to act via epigenetic mechanisms were reported. Therefore, this study aimed to investigate the
Jake J Wen et al.
Journal of the American College of Surgeons, 230(4), 562-571 (2020-02-08)
Mitochondrial oxidative stress plays a prominent role in the development of burn-induced cardiac dysfunction. AMP-activated kinase (AMPK), an energy sensor, has a central role in the pathogenesis of heart failure. However, its role in cardiac dysfunction after burn injury is
Ahmad H Alammari et al.
Drug metabolism and disposition: the biological fate of chemicals, 51(7), 833-843 (2023-05-15)
Aryl hydrocarbon receptor (AhR) is a multifunctional receptor that regulates cytochrome P450 1A1 (CYP1A1), an arachidonic acid (AA) metabolizing enzyme producing 19-hydroxyeicosatetraenoic acid (HETE). 6-formylindolo[3,2-b]carbazole (FICZ) demonstrates great affinity toward the AhR. Recently, we have shown that 19(S)-HETE is preferentially
Zhe Li et al.
Molecular and cellular biochemistry, 476(9), 3241-3252 (2021-04-22)
Heart inflammation is one of the major causes of heart damage that leads to dilated cardiomyopathy and often progresses to end-stage heart failure. In the present study, we aimed to assess whether human cardiac cells could release immune mediators upon
Elastomeric platform with surface wrinkling patterns to control cardiac cell alignment.
House, et al.
Journal of Biomedical Materials Research Part A, 111, 1228-1242 (2023)
Jake Jianjun Wen et al.
PLoS pathogens, 14(5), e1007065-e1007065 (2018-06-01)
Chagasic cardiomyopathy is caused by Trypanosoma cruzi infection. Poly(ADP-ribose) polymerase 1 (PARP1) is known for its function in nuclear DNA repair. In this study, we have employed genetic deletion and chemical inhibition approaches to determine the role of PARP1 in
Wujing Dai et al.
Cells, 12(2) (2023-01-22)
The Nrf2 gene encodes a transcription factor best known for regulating the expression of antioxidant and detoxification genes. A long list of small molecules has been reported to induce Nrf2 protein via Keap1 oxidation or alkylation. Many of these Nrf2
Jiangbin Wu et al.
EMBO molecular medicine, 13(2), e12710-e12710 (2020-12-29)
Aberrant expression of mitochondrial proteins impairs cardiac function and causes heart disease. The mechanism of regulation of mitochondria encoded protein expression during cardiac disease, however, remains underexplored. Here, we show that multiple pathogenic cardiac stressors induce the expression of miR-574
Lorena Pérez-Carrillo et al.
Antioxidants (Basel, Switzerland), 12(7) (2023-07-29)
Ischemic cardiomyopathy (ICM) is associated with abnormal microRNA expression levels that involve an altered gene expression profile. However, little is known about the underlying causes of microRNA disruption in ICM and whether microRNA maturation is compromised. Therefore, we focused on
Naveen Nagiah et al.
ACS omega, 7(16), 13894-13905 (2022-05-14)
In this study, three types of electrospun scaffolds, including furfuryl-gelatin (f-gelatin) alone, f-gelatin with polycaprolactone (PCL) in a 1:1 ratio, and coaxial scaffolds with PCL (core) and f-gelatin (sheath), were developed for tissue engineering applications. Scaffolds were developed through single
Lucia Scisciola et al.
Journal of translational medicine, 21(1), 662-662 (2023-09-24)
Sodium-glucose cotransporter 2 (SGLT2) inhibitors constitute the gold standard treatment for type 2 diabetes mellitus (T2DM). Among them, empagliflozin (EMPA) has shown beneficial effects against heart failure. Because cardiovascular diseases (mainly diabetic cardiomyopathy) are the leading cause of death in
Xin Gu et al.
Experimental and therapeutic medicine, 26(3), 413-413 (2023-08-10)
Doxorubicin (DOX), as a chemotherapy agent with marked therapeutic effect, can be used to treat certain types of cancer such as leukemia, lymphoma and breast cancer. However, the toxic effects of DOX on cardiomyocytes limit its clinical application. Oxidative stress
Characterization of Experimentally Observed Complex Interplay between Pulse Duration, Electrical Field Strength, and Cell Orientation on Electroporation Outcome Using a Time-Dependent Nonlinear Numerical Model.
Scuderi, et al.
Biomolecules, 13 (2023)
Xuejing Sun et al.
Journal of the American Heart Association, 10(1), e016364-e016364 (2020-12-30)
Background ADRB1 (adrenergic receptor beta 1) responds to neuroendocrine stimulations, which have great implications in hypertension. GRK2 (G protein-coupled receptor kinase 2) is an essential regulator for many G protein-coupled receptors and subsequent cell signaling cascades, but its role as
Xin Liu et al.
Clinical and translational medicine, 12(6), e908-e908 (2022-06-28)
The development of heart ageing is the main cause of chronic disability, disease and death in the elderly. Ample evidence has established a pivotal role for significantly reduced mitophagy in the ageing heart. However, the underlying mechanisms of mitophagy deficiency
Shuxuan Li et al.
Journal of virology, 96(21), e0137322-e0137322 (2022-10-14)
Zika virus (ZIKV) is transmitted mostly via mosquito bites and no vaccine is available, so it may reemerge. We and others previously demonstrated that neonatal infection of ZIKV results in heart failure and can be fatal. Animal models implicated ZIKV
Chrysa Koukorava et al.
Cells, 12(20) (2023-10-27)
Mesothelial cells have been shown to have remarkable plasticity towards mesenchymal cell types during development and in disease situations. Here, we have characterized the potential of mesothelial cells to undergo changes toward perivascular cells using an in vitro angiogenesis assay.
Haiyun Wu et al.
BMC cardiovascular disorders, 23(1), 10-10 (2023-01-11)
Cardiomyocytes injury has been considered as a key contributor for myocardial infarction (MI). Uric acid (UA) can induce cardiomyocytes injury, which is closely related to NLRP3 activation and inflammatory factor generation. However, the mechanism how UA modulates cardiomyocytes remains elusive.
Zsófia Onódi et al.
Journal of molecular and cellular cardiology, 165, 19-30 (2021-12-28)
Cardiac cell lines and primary cells are widely used in cardiovascular research. Despite increasing number of publications using these models, comparative characterization of these cell lines has not been performed, therefore, their limitations are undetermined. We aimed to compare cardiac
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