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Showing 1-30 of 38 results for "SCC129" within Papers
Sun Ho Eom et al.
Current issues in molecular biology, 45(10), 8427-8443 (2023-10-27)
Focal cerebral ischemia (fCI) can result in brain injury and sensorimotor deficits. Brown algae are currently garnering scientific attention as potential therapeutic candidates for fCI. This study investigated the therapeutic effects of the hot water extract of Petalonia binghamiae (wPB)
Yuting Cui et al.
Antioxidants (Basel, Switzerland), 10(11) (2021-11-28)
NF-E2-related factor 2 (Nrf2), the key transcription regulator of phase II enzymes, has been considered beneficial for neuronal protection. We previously designed a novel chalcone analog, 1-(2,3,4-trimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-acrylketone (Tak), that could specifically activate Nrf2 in vitro. Here, we report that Tak
Yujiao Lu et al.
International journal of molecular sciences, 23(10) (2022-05-29)
Hemoglobin (Hb) is the oxygen transport protein in erythrocytes. In blood, Hb is a tetramer consisting of two Hb-alpha (Hb-α) chains and two Hb-beta (Hb-β) chains. A number of studies have also shown that Hb-α is also expressed in neurons
Oliwia Koszła et al.
Molecules (Basel, Switzerland), 27(7) (2022-04-13)
Neurodegenerative and mental diseases are serious medical, economic and social problems. Neurodegeneration is referred to as a pathological condition associated with damage to nerve cells leading to their death. Treatment of neurodegenerative diseases is at present symptomatic only, and novel
Wei Jing et al.
Cell reports, 37(13), 110177-110177 (2021-12-30)
The hippocampus is a temporal lobe structure critical for cognition, such as learning, memory, and attention, as well as emotional responses. Hippocampal dysfunction can lead to persistent anxiety and/or depression. However, how millions of neurons in the hippocampus are molecularly
Aifang Cheng et al.
Autophagy, 17(8), 1998-2010 (2020-08-08)
ATM (ataxia telangiectasia mutated) protein is found associated with multiple organelles including synaptic vesicles, endosomes and lysosomes, often in cooperation with ATR (ataxia telangiectasia and Rad3 related). Mutation of the ATM gene results in ataxia-telangiectasia (A-T), an autosomal recessive disorder
Verónica Noches et al.
Biochemistry and biophysics reports, 25, 100889-100889 (2021-01-12)
Epilepsy is a neurological disorder of genetic or environmental origin characterized by recurrent spontaneous seizures. A rodent model of temporal lobe epilepsy is induced by a single administration of pilocarpine, a non-selective cholinergic muscarinic receptor agonist. The molecular changes associated
Zhong Peng et al.
Viruses, 15(1) (2023-01-22)
Pseudorabies virus (PRV) generally infects pigs and threatens the pig industry. However, recently we have isolated a PRV strain designated hSD-1/2019 from infected humans. In this study, we compared the complete genome sequence of hSD-1/2019 with those of pig-originated PRV
Alice Rossi et al.
Cell reports, 30(7), 2332-2348 (2020-02-23)
Mitochondria are key organelles for brain health. Mitochondrial alterations have been reported in several neurodegenerative disorders, including Alzheimer's disease (AD), and the comprehension of the underlying mechanisms appears crucial to understand their relationship with the pathology. Using multiple genetic, pharmacological
Min Li et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 37(10), e23178-e23178 (2023-09-12)
Systemic inflammatory response syndrome (SIRS), at least in part driven by necroptosis, is characterized by life-threatening multiple organ failure. Blocking the progression of SIRS and consequent multiple organ dysfunction is challenging. Receptor-interacting serine/threonine protein kinase 1 (RIPK1) is an important
Daixuan Zhou et al.
Experimental and therapeutic medicine, 22(1), 789-789 (2021-06-01)
Ischemic stroke is a complication of chronic macrovascular disease in type 2 diabetes. However, the pathogenesis of diabetic ischemic stroke has not yet been fully clarified. The aim of the present study was to investigate the underlying effects of endothelial
B H Morimoto et al.
Neuron, 5(6), 875-880 (1990-12-11)
In a neural cell line, the secretion of excitatory amino acids in response to a depolarizing stimulus is potentiated by the addition of serotonin. The duration of this potentiation is dependent on the strength of the stimulus. Persistent secretory potentiation
Anastasia Agapouda et al.
Oxidative medicine and cellular longevity, 2022, 5647599-5647599 (2022-05-24)
Sustained stress with the overproduction of corticosteroids has been shown to increase reactive oxygen species (ROS) leading to an oxidative stress state. Mitochondria are the main generators of ROS and are directly and detrimentally affected by their overproduction. Neurons depend
Oliwia Koszła et al.
International journal of molecular sciences, 21(22) (2020-11-27)
The treatment of memory impairments associated with the central nervous system diseases remains an unmet medical need with social and economic implications. Here we show, that a multi-target ligand of aminergic G protein-coupled receptors with antipsychotic activity in vivo (D2AAK1)
Sukrit Promtang et al.
IBRO neuroscience reports, 14, 38-49 (2023-01-03)
The anti-apoptosis effect of germinated brown rice (GBR) focusing on differentiated HT22 cells results in improved nutritional values after the germination process of GBR which contains total phenolic compounds and γ-aminobutyric acid (GABA). Cell death induced by 5 mM glutamate was
Qiang Gao et al.
International journal of molecular sciences, 23(21) (2022-11-12)
More research is required to understand how melatonin protects neurons. The study aimed to find out if and how long non-coding RNA (lncRNA) contributes to melatonin's ability to defend the hippocampus from H2O2-induced oxidative injury. LncRNAs related to oxidative injury
Chen-Ling Gan et al.
International journal of molecular sciences, 23(12) (2022-06-25)
Glutamate excitotoxicity induces neuronal cell death during epileptic seizures. Death-associated protein kinase 1 (DAPK1) expression is highly increased in the brains of epilepsy patients; however, the underlying mechanisms by which DAPK1 influences neuronal injury and its therapeutic effect on glutamate
J B Davis et al.
Brain research, 652(1), 169-173 (1994-07-25)
A neuronal cell line, HT-22, is sensitive to glutamate cytotoxicity via a non-receptor mediated oxidative pathway. 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C, blocks this glutamate-induced cell death. Down-regulation of protein kinase C eliminates the protection against glutamate cytotoxicity
Ye Yuan et al.
Nature communications, 14(1), 5808-5808 (2023-09-20)
Amyloid-like assembly is not only associated with pathological events, but also leads to the development of novel nanomaterials with unique properties. Herein, using Fmoc diphenylalanine peptide (Fmoc-F-F) as a minimalistic model, we found that histidine can modulate the assembly behavior
Josué Ballesteros-Álvarez et al.
GeroScience, 45(2), 1095-1113 (2022-12-29)
In the present study, we investigated the effects of urolithin A (UA), a metabolite generated from ellagic acid via its metabolism by gut bacteria, as an autophagy activator with potential neuroprotective activity. WT and 3xTg-AD mice were administered long-term intermittent
Redefining the role of AMPK in autophagy and the energy stress response.
Park, et al.
Nature Communications, 14, 2994-2994 (2023)
Eunjin Sohn et al.
Molecular neurobiology, 58(8), 3665-3676 (2021-04-03)
We examined the neuropharmacological effects of ethanol extract of Ficus erecta Thunb leaves (EEFE) on cognitive dysfunction in a scopolamine (SCO)-induced memory impairment animal model. Memory impairment was measured using the Y-maze test and passive avoidance task (PAT). For 19
Yuanyuan Zhao et al.
Nature communications, 13(1), 1121-1121 (2022-03-04)
Predisposition to Alzheimer's disease (AD) may arise from lipid metabolism perturbation, however, the underlying mechanism remains elusive. Here, we identify ATPase family AAA-domain containing protein 3A (ATAD3A), a mitochondrial AAA-ATPase, as a molecular switch that links cholesterol metabolism impairment to
Daniel J Rees et al.
Current protocols in neuroscience, 94(1), e105-e105 (2020-11-05)
Neuronal mitochondrial fragmentation is a phenotype exhibited in models of neurodegeneration such as Parkinson's disease. Delineating the dysfunction in mitochondrial dynamics found in diseased states can aid our understanding of underlying mechanisms of disease progression and possibly identify novel therapeutic
Brian K A Choi et al.
PloS one, 14(8), e0220056-e0220056 (2019-08-02)
Abortive cell cycle (ACC) re-entry of apoptotic neurons is a recently characterized phenomenon that occurs after central nervous system (CNS) injury or over the course of CNS disease. Consequently, inhibiting cell cycle progression is neuroprotective in numerous CNS pathology models.
Peng Huang et al.
Annals of translational medicine, 9(20), 1594-1594 (2021-11-19)
Phosphodiesterase 4D (PDE4D) inhibitor is commonly used to treat depression, but side effects seriously decrease its efficacy. PDE4D was a downstream target mRNA of miR-139-5p. Therefore, we examined the effects of hippocampal miR-139-5p gain- and loss-of-function on depression-like behaviors, the
Yubo Cheng et al.
eLife, 9 (2020-11-17)
The functional importance of many non-coding RNAs (ncRNAs) generated by repetitive elements and their connection with pathologic processes remains elusive. B2 RNAs, a class of ncRNAs of the B2 family of SINE repeats, mediate through their processing the transcriptional activation
Eikan Mishima et al.
Nature, 608(7924), 778-783 (2022-08-04)
Ferroptosis, a non-apoptotic form of cell death marked by iron-dependent lipid peroxidation1, has a key role in organ injury, degenerative disease and vulnerability of therapy-resistant cancers2. Although substantial progress has been made in understanding the molecular processes relevant to ferroptosis
Mitsuaki Nishikimi et al.
Annals of neurology, 91(3), 389-403 (2022-01-04)
Cardiac arrest (CA) is a major health burden with brain damage being a significant contributor to mortality. We found lysophosphatidylcholine (LPC), including a species containing docosahexaenoic acid (LPC-DHA), was significantly decreased in plasma post-CA, supplementation of which significantly improved neurological
Upregulation of CDGSH iron sulfur domain 2 attenuates cerebral ischemia/reperfusion injury.
Hu, et al.
Neural Regeneration Research, 18, 1512-1520 (2023)
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