SHC201

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Showing 1-13 of 13 results for "SHC201" within Papers

ZNF416 is a pivotal transcriptional regulator of fibroblast mechanoactivation.

Dakota L Jones et al.

The Journal of cell biology, 220(5) (2021-02-25)

Matrix stiffness is a central regulator of fibroblast function. However, the transcriptional mechanisms linking matrix stiffness to changes in fibroblast phenotype are incompletely understood. Here, we evaluated the effect of matrix stiffness on genome-wide chromatin accessibility in freshly isolated lung

SENP2 suppresses NF-κB activation and sensitizes breast cancer cells to doxorubicin.

Xiaoyu Gao et al.

European journal of pharmacology, 854, 179-186 (2019-04-04)

Doxorubicin is a chemotherapeutic agent commonly used to treat breast cancer. However, breast cancer often develops drug resistance, leading to disease recurrence and poor prognosis. Delineating the mechanisms underlying drug resistance is imperative for overcoming the challenge of treating doxorubicin-resistant

Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia.

Cuellar TL, et al.

The Journal of Cell Biology (2017)

Platinum-Induced Ubiquitination of Phosphorylated H2AX by RING1A Is Mediated by Replication Protein A in Ovarian Cancer.

Shruthi Sriramkumar et al.

Molecular cancer research : MCR, 18(11), 1699-1710 (2020-08-18)

Platinum resistance is a common occurrence in high-grade serous ovarian cancer and a major cause of ovarian cancer deaths. Platinum agents form DNA cross-links, which activate nucleotide excision repair (NER), Fanconi anemia, and homologous recombination repair (HRR) pathways. Chromatin modifications

Activated Wnt/β-Catenin signaling contributes to E3 ubiquitin ligase EDD-conferred docetaxel resistance in prostate cancer.

Pan Bian et al.

Life sciences, 254, 116816-116816 (2019-09-01)

Docetaxel is commonly used to treat hormone-refractory prostate cancer (HRPC), but its clinical efficacy is limited by drug resistance, with the molecular mechanisms remaining elusive. The E3 ubiquitin ligase EDD modifies substrate proteins through ubiquitination and is involved in the

miR-21a in exosomes from Lewis lung carcinoma cells accelerates tumor growth through targeting PDCD4 to enhance expansion of myeloid-derived suppressor cells.

Xingju Zhang et al.

Oncogene, 39(40), 6354-6369 (2020-08-29)

In patients with lung cancer, myeloid-derived suppressor cells (MDSCs) have been reported to be significantly increased. Tumor-derived exosomes (TDEs) from various cancers played a critical role in MDSC induction. However, studies on the molecular mechanism underlying MDSC expansion induced by

Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.

R Zufferey et al.

Journal of virology, 73(4), 2886-2892 (1999-03-12)

The expression of genes delivered by retroviral vectors is often inefficient, a potential obstacle for their widespread use in human gene therapy. Here, we explored the possibility that the posttranscriptional regulatory element of woodchuck hepatitis virus (WPRE) might help resolve

A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC.

Dompe N, et al.

PLoS ONE, 13(6), e0199264-e0199264 (2018)

CPEB4-Promoted Paclitaxel Resistance in Ovarian Cancer In Vitro Relies on Translational Regulation of CSAG2.

Yaqing Zhang et al.

Frontiers in pharmacology, 11, 600994-600994 (2021-02-02)

Background: Drug resistance is a major obstacle in chemotherapy for ovarian cancer, wherein the up regulation of drug-resistant genes plays an important role. The cytoplasmic polyadenylation element binding protein 4 (CPEB4) is an RNA binding protein that controls mRNA cytoplasmic

Functional screening implicates miR-371-3p and peroxiredoxin 6 in reversible tolerance to cancer drugs.

Sahu N, et al.

Nature Communications, 7, 12351-12351 (2016)

p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival.

Longfei Deng et al.

Nature communications, 11(1), 1755-1755 (2020-04-11)

Asparagine synthetase (ASNS) catalyses the ATP-dependent conversion of aspartate to asparagine. However, both the regulation and biological functions of asparagine in tumour cells remain largely unknown. Here, we report that p53 suppresses asparagine synthesis through the transcriptional downregulation of ASNS

Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice.

Janet Lau et al.

Nature communications, 8, 14572-14572 (2017-02-22)

Expression of PD-L1, the ligand for T-cell inhibitory receptor PD-1, is one key immunosuppressive mechanism by which cancer avoids eradication by the immune system. Therapeutic use of blocking antibodies to PD-L1 or its receptor PD-1 has produced unparalleled, durable clinical

Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element.

J E Donello et al.

Journal of virology, 72(6), 5085-5092 (1998-05-30)

The hepatitis B virus posttranscriptional regulatory element (HBVPRE) is a cis-acting RNA element that partially overlaps with enhancer I and is required for the cytoplasmic accumulation of HBV surface RNAs. We find that the closely related woodchuck hepatitis virus (WHV)

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