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Showing 1-16 of 16 results for "SML0221" within Papers
Piperlongumine induces gastric cancer cell apoptosis and G2/M cell cycle arrest both in vitro and in vivo
Duan C, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(8), 10793-10804 (2016)
Xin-xin Xiong et al.
Acta pharmacologica Sinica, 36(3), 362-374 (2015-01-27)
To investigate the effects of piperlongumine (PL), an anticancer alkaloid from long pepper plants, on the primary myeloid leukemia cells from patients and the mechanisms of action. Human BM samples were obtained from 9 patients with acute or chronic myeloid
Alhassan Aodah et al.
PloS one, 11(3), e0151707-e0151707 (2016-03-18)
Piperlongumine is a natural alkaloid extracted from piper plants which has been used traditionally for the treatment of certain diseases. This compound shows interesting in vitro pharmacological activity such as selective anticancer activity and higher cytotoxicity than methotrexate, cyclophosphamide and
ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription
Li K, et al.
Testing, 6(35), 38107-38107 (2015)
Piperlongumine Induces Apoptosis in Human Melanoma Cells Via Reactive Oxygen Species Mediated Mitochondria Disruption
Song X, et al.
Nutrition and Cancer, 70(3), 502-511 (2018)
Piperlongumine inhibits neuroinflammation via regulating NF-kappaB signaling pathways in lipopolysaccharide-stimulated BV2 microglia cells
Kim N, et al.
Journal of Pharmacological Sciences, 137(2), 195-201 (2018)
Monielle Sant'Ana et al.
Pulmonary pharmacology & therapeutics, 61, 101896-101896 (2020-01-29)
Chronic obstructive pulmonary disease (COPD) is related to smoking and anti-inflammatory therapy is indicated. Among the mediators with anti-inflammatory properties, we highlight piperlongumine (PL), an alkaloid/amide of Piper longum. Here we evaluated the PL administration on an experimental model of
Jie Liang et al.
Frontiers in immunology, 11, 1172-1172 (2020-07-01)
Piperlongumine (PL), a natural small molecule derived from the Piper longum Linn plant, has received growing interest as a prooxidative drug with promising anticancer properties. Yet, the influence of PL on primary human T cells remained elusive. Knowledge of this
Andreia Teixeira-Castro et al.
Brain : a journal of neurology, 138(Pt 11), 3221-3237 (2015-09-17)
Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We identified citalopram, a selective serotonin
Elevated PRC1 in gastric carcinoma exerts oncogenic function and is targeted by piperlongumine in a p53-dependent manner
Zhang B, et al.
Journal of Cellular and Molecular Medicine, 21(7), 1329-1341 (2017)
Ding-Fang Zhang et al.
BMC complementary medicine and therapies, 21(1), 195-195 (2021-07-08)
Metastatic castration-resistant prostate cancer (CRPC) is the leading cause of death among men diagnosed with prostate cancer. Piperlongumine (PL) is a novel potential anticancer agent that has been demonstrated to exhibit anticancer efficacy against prostate cancer cells. However, the effects
Piperlongumine induces apoptosis and synergizes with cisplatin or paclitaxel in human ovarian cancer cells
Gong LH, et al.
Oxidative Medicine and Cellular Longevity, 2014 (2014)
Ketan Patel et al.
Journal of pharmaceutical sciences, 104(12), 4417-4426 (2015-09-16)
Very low oral bioavailability due to extensive pre-systemic metabolism and P-gp efflux has constrained the oral metronomic chemotherapy of docetaxel (DTX). There is tremendous need of compounds facilitating oral delivery of DTX. The research was aimed to investigate the effect
Wenxiang Shi et al.
Frontiers in cardiovascular medicine, 7, 625215-625215 (2021-03-02)
Vascular calcification frequently occurs in the process of chronic kidney disease, atherosclerosis and aging, resulting in an increased prevalence of cardiovascular events. Piperlongumine (PLG) is a natural product isolated from Piper longum L. Here, we aimed to explore the effect
Piperlongumine suppresses growth and sensitizes pancreatic tumors to gemcitabine in a xenograft mouse model by modulating the NF-kappa B pathway
Wang Y, et al.
Cancer Prevention Research (Philadelphia, Pa.), 9(3), 234-244 (2016)
Piperlongumine inhibits cancer stem cell properties and regulates multiple malignant phenotypes in oral cancer
Chen YJ, et al.
Oncology Letters, 15(2), 1789-1798 (2018)
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