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Showing 1-13 of 13 results for "SML0341" within Papers
Shengping Huang et al.
The Journal of biological chemistry, 296, 100117-100117 (2020-11-26)
Kinesin is part of the microtubule-binding motor protein superfamily, which serves important roles in cell division and intraorganellar transport. The heterotrimeric kinesin-2, consisting of the heterodimeric motor subunits, kinesin family member 3A/3B (KIF3A/3B), and kinesin-associated protein 3 (KAP3), is highly
Cheong-Yong Yun et al.
Theranostics, 9(3), 646-660 (2019-02-28)
Rationale: SOX10 (SRY-related HMG-box 10) and MITF-M (microphthalmia-associated transcription factor M) restrict the expression of melanogenic genes, such as TYR (tyrosinase), in melanocytes. DACE (diacetylcaffeic acid cyclohexyl ester) inhibits melanin production in α-MSH (α-melanocyte stimulating hormone)-activated B16-F0 melanoma cells. In
Andrea Dimitracopoulos et al.
Current biology : CB, 30(18), 3687-3696 (2020-08-01)
Proliferating animal cells are able to orient their mitotic spindles along their interphase cell axis, setting up the axis of cell division, despite rounding up as they enter mitosis. This has previously been attributed to molecular memory and, more specifically
Sachin Kotak et al.
The EMBO journal, 33(16), 1815-1830 (2014-07-06)
The positioning and the elongation of the mitotic spindle must be carefully regulated. In human cells, the evolutionary conserved proteins LGN/Gαi1-3 anchor the coiled-coil protein NuMA and dynein to the cell cortex during metaphase, thus ensuring proper spindle positioning. The
Patrycja Kozik et al.
Cell reports, 32(2), 107905-107905 (2020-07-16)
Cross-presentation of antigens by dendritic cells (DCs) is critical for initiation of anti-tumor immune responses. Yet, key steps involved in trafficking of antigens taken up by DCs remain incompletely understood. Here, we screen 700 US Food and Drug Administration (FDA)-approved drugs
VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and Abeta accumulation via enhancement of ERK phosphatase VHR activity
Song H, et al.
Scientific reports, 6, 38452-38452 (2016)
Nuclear Entry of CRTC1 as Druggable Target of Acquired Pigmentary Disorder
Yun CY, et al.
Theranostics, 9(3), 646-646 (2019)
Gonzalo Federico Mayol et al.
Biochimica et biophysica acta. Molecular cell research, 1867(1), 118566-118566 (2019-11-02)
Nuclear-cytoplasmic trafficking of proteins is a highly regulated process that modulates multiple biological processes in eukaryotic cells. In Giardia lamblia, shuttling has been described from the cytoplasm to nuclei of proteins during the biological cell cycle of the parasite. This
Hermes Taylor-Weiner et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(6), 2978-2986 (2020-01-29)
Skeletal muscle cells contain hundreds of myonuclei within a shared cytoplasm, presenting unique challenges for regulating gene expression. Certain transcriptional programs (e.g., postsynaptic machinery) are segregated to specialized domains, while others (e.g., contractile proteins) do not show spatial confinement. Furthermore
Felix E Nolet et al.
eLife, 9 (2020-05-27)
Traveling waves play an essential role in coordinating mitosis over large distances, but what determines the spatial origin of mitotic waves remains unclear. Here, we show that such waves initiate at pacemakers, regions that oscillate faster than their surroundings. In
Mutant p53 gains its function via c-Myc activation upon CDK4 phosphorylation at serine 249 and consequent PIN1 binding
Liao P, et al.
Molecular Cell, 68(6), 1134-1146 (2017)
Essential elements for translation: the germline factor Vasa functions broadly in somatic cells
Yajima M and Wessel GM
Development, 142(11), 1960-1970 (2015)
High fat diet-induced oxidative stress blocks hepatocyte nuclear factor 4alpha and leads to hepatic steatosis in mice
Yu D, et al.
Journal of Cellular Physiology, 233(6), 4770-4782 (2018)
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