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Showing 1-12 of 12 results for "SRP3227" within Papers
Elena Layunta et al.
Cell reports, 34(7), 108757-108757 (2021-02-18)
The intestine is under constant exposure to chemicals, antigens, and microorganisms from the external environment. Apical aspects of transporting epithelial cells (enterocytes) form a brush-border membrane (BBM), shaped by packed microvilli coated with a dense glycocalyx. We present evidence showing
Jae-Hyun Kim et al.
Frontiers in pharmacology, 12, 690113-690113 (2021-08-06)
Fracture healing is related to osteogenic differentiation and mineralization. Recently, due to the unwanted side effects and clinical limitations of existing treatments, various natural product-based chemical studies have been actively conducted. Albiflorin is a major ingredient in Paeonia lactiflora, and
E Minina et al.
Development (Cambridge, England), 128(22), 4523-4534 (2001-11-21)
During endochondral ossification, two secreted signals, Indian hedgehog (Ihh) and parathyroid hormone-related protein (PTHrP), have been shown to form a negative feedback loop regulating the onset of hypertrophic differentiation of chondrocytes. Bone morphogenetic proteins (BMPs), another family of secreted factors
Bruce A Corliss et al.
Investigative ophthalmology & visual science, 60(15), 5095-5103 (2019-12-12)
To establish Myh11 as a marker of a subset of corneal endothelial cells (CECs), and to demonstrate the feasibility of restoring the corneal endothelium with Myh11-lineage (Myh11-Lin[+]) adipose-derived stromal cells (ASCs). Intraperitoneal administration of tamoxifen and (Z)-4-hydroxytamoxifen eyedrops were used
The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.
Zimmerman LB, et al.
Cell, 86(4), 599-606 (1996)
Noggin antagonizes BMP signaling to create a niche for adult neurogenesis.
Lim DA, et al.
Neuron, 28(3), 713-726 (2000)
Conditional inactivation of noggin in the postnatal skeleton causes osteopenia.
Canalis E, et al.
Endocrinology, 153(4), 1616-1626 (2012)
Riccardo Sangermano et al.
Ophthalmology, 123(6), 1375-1385 (2016-03-16)
To elucidate the functional effect of the ABCA4 variant c.5461-10T→C, one of the most frequent variants associated with Stargardt disease (STGD1). Case series. Seventeen persons with STGD1 carrying ABCA4 variants and 1 control participant. Haplotype analysis of 4 homozygotes and
Naren P Tallapragada et al.
Cell stem cell, 28(9), 1516-1532 (2021-04-30)
How stem cells self-organize to form structured tissues is an unsolved problem. Intestinal organoids offer a model of self-organization as they generate stem cell zones (SCZs) of typical size even without a spatially structured environment. Here we examine processes governing
David A Monteiro et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(3), e21263-e21263 (2021-02-12)
Bone is a dynamic tissue that constantly adapts to changing mechanical demands. The transforming growth factor beta (TGFβ) signaling pathway plays several important roles in maintaining skeletal homeostasis by both coupling the bone-forming and bone-resorbing activities of osteoblasts and osteoclasts
L J Brunet et al.
Science (New York, N.Y.), 280(5368), 1455-1457 (1998-06-20)
Noggin is a bone morphogenetic protein (BMP) antagonist expressed in Spemann's organizer. Murine Noggin is expressed in condensing cartilage and immature chondrocytes, as are many BMPs. In mice lacking Noggin, cartilage condensations initiated normally but developed hyperplasia, and initiation of
Yong-Guo Zhang et al.
Autophagy, 15(11), 1935-1953 (2019-03-22)
Extracellular HMGB1 (high mobility group box 1) is considered as a damage-associated molecular pattern protein. However, little is known about its intracellular role. We studied the mechanism whereby intestinal epithelial HMGB1 contributes to host defense, using cell culture, colonoids, conditional
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