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Showing 1-30 of 55 results for "SRP4039" within Papers
Daniela A Parodi et al.
Reproductive toxicology (Elmsford, N.Y.), 54, 66-75 (2014-12-30)
Early life exposure to estrogens and estrogen like contaminants in the environment is thought to contribute to the early onset of puberty and consequently increases the risk of developing breast cancer in the exposed female. The results of this study
Hai-Ke Lu et al.
Pharmaceutical biology, 58(1), 1184-1191 (2020-12-01)
Clinically, Pinellia ternata (Thunb.) Breit. (Araceae) (PT) has been widely used in the treatment of atherosclerosis and hyperlipidaemia, but the underlying mechanisms are still not clearly understood. This research was conducted to confirm the mechanism by which PT affects carotid
Kirsten S Evonuk et al.
Journal of immunology (Baltimore, Md. : 1950), 195(2), 450-463 (2015-06-14)
T cell infiltration into the CNS is a significant underlying pathogenesis in autoimmune inflammatory demyelinating diseases. Several lines of evidence suggest that glutamate dysregulation in the CNS is an important consequence of immune cell infiltration in neuroinflammatory demyelinating diseases; yet
Yasemin Kartal et al.
Implant dentistry, 23(4), 463-470 (2014-07-23)
The aim of this study was to evaluate the implant stability with the addition of local application of basic fibroblast growth factor (bFGF) during the osseointegration of 2 different dental implant surfaces using rabbit tibia model. Fifty-six dental implants, 28
Matthias Ilmer et al.
Molecular cancer therapeutics, 14(12), 2712-2721 (2015-10-31)
The substance P (SP)/NK-1 receptor (NK1R) complex represents an intriguing anticancer target for a variety of tumors, including hepatoblastoma (HB). Therefore, NK1R antagonists, such as the clinical drug aprepitant, recently have been proposed as potent anticancer agents. However, very little
Kazumichi Yoshida et al.
Cancer medicine, 4(9), 1322-1333 (2015-06-17)
CD47 is an antiphagocytic molecule that acts via ligation to signal regulatory protein alpha on phagocytes; its enhanced expression and therapeutic targeting have recently been reported for several malignancies. However, CD47 expression in gastric cancer is not well documented. Immunohistochemical
Wenchao Xu et al.
Molecular carcinogenesis, 54 Suppl 1, E148-E161 (2014-09-25)
Lung cancer is the leading cause of cancer mortality worldwide. A common interest in lung cancer research is the identification of biomarkers for early diagnosis and accurate prognosis. There is increasing evidence that microRNAs (miRNAs) are involved in lung cancer.
Dongmei Lai et al.
Scientific reports, 5, 10014-10014 (2015-05-08)
Culture conditions that support the growth of undifferentiated human embryonic stem cells (hESCs) have already been established using primary human amnion epithelial cells (hAECs) as an alternative to traditional mitotically inactivated mouse embryonic fibroblasts (MEFs). In the present work, inner
Shun Yamamuro et al.
International journal of oncology, 47(1), 91-96 (2015-05-09)
Glioma stem-like cells (GSCs) could have potential for tumorigenesis, treatment resistance, and tumor recurrence (GSC hypothesis). However, the mechanisms underlying such potential has remained elusive and few ultrastructural features of the cells have been reported in detail. We therefore undertook
G Riddick et al.
The pharmacogenomics journal, 15(4), 347-353 (2014-12-03)
Cancer stem cells (CSCs) are thought to promote resistance to chemotherapeutic drugs in glioblastoma, the most common and aggressive primary brain tumor. However, the use of high-throughput drug screens to discover novel small-molecule inhibitors for CSC has been hampered by
Ruo-Lang Pan et al.
Hepatology (Baltimore, Md.), 61(5), 1708-1720 (2014-12-17)
Liver fibrosis, a major cause of end-stage liver diseases, is closely regulated by multiple growth factors and cytokines. The correlation of fibroblast growth factor 2 (FGF2) with chronic liver injury has been reported, but the exact functions of different FGF2
Shuping Wei et al.
Journal of molecular and cellular cardiology, 87, 17-26 (2015-08-14)
The differentiation of endothelial progenitor cells (EPCs) plays a pivotal role in endothelial repair and re-endothelialization after vascular injury. However, the underlying mechanisms still remain largely elusive. Here, we investigated the role of the novel C2H2 zinc finger transcription factor
Guo-Fang Guan et al.
Molecular medicine reports, 12(3), 4352-4357 (2015-06-18)
The presence of cancer stem cells (CSCs) has major implications in the choice of cancer treatment strategy and is responsible for tumor relapse. CSCs have been isolated and characterized in several types of cancer; however, studies concerning the CSCs from
Zulfikar Arlier et al.
The International journal of neuroscience, 125(4), 288-297 (2014-06-05)
Hypertension impairs cerebral vascular function. Vasodilator-stimulated phosphoprotein (VASP) mediates active reorganization of the cytoskeleton via membrane ruffling, aggregation and tethering of actin filaments. VASP regulation of endothelial barrier function has been demonstrated by studies using VASP(-/-) animals under conditions associated
Wei Cheng et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 35(5), 2019-2032 (2015-04-15)
There is interest in drugs and rehabilitation methods to enhance neurogenesis and improve neurological function after brain injury or degeneration. Resveratrol may enhance hippocampal neurogenesis and improve hippocampal atrophy in chronic fatigue mice and prenatally stressed rats. However, its effect
Han Wang et al.
Stem cells and development, 24(21), 2536-2546 (2015-07-02)
Definitive endoderm (DE) is a vital precursor for internal organs such as liver and pancreas. Efficient protocol to differentiate human embryonic stem cells (hESCs) or induced pluripotent stem cells (iPSCs) to DE is essential for regenerative medicine and for modeling
Natalia Platonova et al.
PloS one, 9(10), e110055-e110055 (2014-10-10)
Fibroblast growth factor-2 (FGF2) is a pleiotropic growth factor exhibiting a variety of biological activities. In this article, we studied the capacity of FGF2 purified with or without heparin affinity chromatography to self-associate. Analyzing the NMR HSQC spectra for different
Ge Li et al.
Acta pharmacologica Sinica, 31(11), 1454-1463 (2010-10-19)
To examine whether implantation of islet preparation-derived proliferating islet cells (PIC) could ameliorate diabetes in rats. PIC were expanded from rat islet preparation by supplementation of basic fibroblast growth factor (bFGF) and implanted into rats with streptozotocin (STZ)-induced diabetes through
FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation.
Molecular and Cellular Biology, 18(10), 6063-6074 (1998)
A Bertolo et al.
European cells & materials, 29, 70-80 (2015-01-13)
Degeneration of the intervertebral disc (IVD) is a progressive and chronic process, and the high incidence of discogenic disorders calls for new therapeutic approaches, such as cell-based therapies using three dimensional cultures and mesenchymal stem cells (MSC), which can differentiate
Wai Kit Chan et al.
PloS one, 10(6), e0130147-e0130147 (2015-06-16)
Heparan sulfate (HS) is a linear carbohydrate composed of polymerized uronate-glucosamine disaccharide units that decorates cell surface and secreted glycoproteins in the extracellular matrix. In mammals HS is subjected to differential sulfation by fifteen different heparan sulfotransferase (HST) enzymes of
Marina Jerebtsova et al.
American journal of physiology. Heart and circulatory physiology, 309(8), H1314-H1325 (2015-08-16)
Critically ill children can develop bleeding complications when treated with heparin-like drugs. These events are usually attributed to the anticoagulant activity of these drugs. However, previous studies showed that fibroblast growth factor-2 (FGF-2), a heparin-binding growth factor released in the
Apocynin Attenuates Cardiac Injury in Type 4 Cardiorenal Syndrome via Suppressing Cardiac Fibroblast Growth Factor-2 With Oxidative Stress Inhibition.
Liu Y
Journal of the American Heart Association, 4(7), e001598-e001598 (2015)
Xiumei Zhao et al.
Neuro-oncology, 17(7), 965-977 (2014-12-30)
New therapeutic targets are needed to eliminate cancer stem cells (CSCs). We hypothesize that direct comparison of paired CSCs and nonstem tumor cells (NSTCs) will facilitate identification of primary "driver" chromosomal aberrations that can serve as diagnostic markers and/or therapeutic
Kun Zhang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 23(6), 1077-1091 (2015-03-21)
Spinal cord injury (SCI) frequently provokes serious detrimental outcomes because neuronal regeneration is limited in the central nervous system (CNS). Thus, the creation of a permissive environment for transplantation therapy with neural stem/progenitor cells (NS/PCs) is a promising strategy to
Yayoi Yoshimura et al.
PloS one, 10(6), e0128288-e0128288 (2015-06-04)
Glioblastoma multiforme (GBM) is associated with high mortality due to infiltrative growth and recurrence. Median survival of the patients is less than 15 months, increasing requirements for new therapies. We found that both arsenic trioxide and 10058F4, an inhibitor of
Xi Feng et al.
Oncotarget, 6(17), 15077-15094 (2015-05-20)
The most abundant populations of non-neoplastic cells in the glioblastoma (GBM) microenvironment are resident microglia, macrophages and infiltrating monocytes from the blood circulation. The mechanisms by which monocytes infiltrate into GBM, their fate following infiltration, and their role in GBM
Chian-Shiu Chien et al.
Cancer research, 75(12), 2553-2565 (2015-04-11)
Lin28, a key factor for cellular reprogramming and generation of induced pluripotent stem cell (iPSC), makes a critical contribution to tumorigenicity by suppressing Let-7. However, it is unclear whether Lin28 is involved in regulating cancer stem-like cells (CSC), including in
Galbha Duggal et al.
Stem cells (Dayton, Ohio), 33(9), 2686-2698 (2015-06-26)
Human embryonic stem cells (hESCs) closely resemble mouse epiblast stem cells exhibiting primed pluripotency unlike mouse ESCs (mESCs), which acquire a naïve pluripotent state. Efforts have been made to trigger naïve pluripotency in hESCs for subsequent unbiased lineage-specific differentiation, a
Zsuzsanna Táncos et al.
Gene, 566(2), 148-157 (2015-04-22)
While the rabbit (Oryctolagus cuniculus) is an important research model for aspects of human development and disease that cannot be studied in rodents, the lack of data on the genetic regulation of rabbit preimplantation development is a limitation. To assist
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