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Showing 1-30 of 123 results for "stro-1" within Papers
Stephen Fitter et al.
Stem cells (Dayton, Ohio), 35(4), 940-951 (2016-12-28)
Since its discovery more than 25 years ago, the STRO-1 antibody has played a fundamental role in defining the hierarchical nature of mesenchymal precursor cells (MPC) and their progeny. STRO-1 antibody binding remains a hallmark of immature pluripotent MPC. Despite
Pinar Ercal et al.
Archives of oral biology, 82, 293-301 (2017-07-08)
Mesenchymal stem cells derived from the human tooth germ (hTGSCs) are a heterogeneous cell population that can differentiate into osteogenic, neurogenic, and adipogenic lineages. The aim of this study was to compare the osteogenic differentiation capacity of STRO-1 positive (STRO-1+)
Yoshiaki Hoshiyama et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(4), 548-555 (2015-02-19)
The purpose of this study was to investigate the site-specific characteristics and roles of chondrocyte clusters in human knee osteoarthritis. Cartilage explants were obtained from 45 knees undergoing total knee replacement surgery. The explants were taken from 4 locations in
Gorke Gurel Pekozer et al.
Artificial cells, nanomedicine, and biotechnology, 46(3), 607-618 (2017-06-01)
Stem cells of dental origin emerged as a new source for the regeneration of tissues with advantages mainly including non-invasive collection procedures and lack of ethical contraversies with their harvest or use. In this study, porcine TGSCs (pTGSCs) were isolated
Rebekah M Samsonraj et al.
Stem cells (Dayton, Ohio), 33(6), 1878-1891 (2015-03-11)
This study sought to identify critical determinants of mesenchymal stem cell (MSC) potency using in vitro and in vivo attributes of cells isolated from the bone marrow of age- and sex-matched donors. Adherence to plastic was not indicative of potency
H Chopra et al.
Journal of translational medicine, 16(1), 174-174 (2018-06-23)
Human periodontal ligament stem cells (hPDLSCs) have been shown to be a reliable source of mesenchymal stem cells (MSCs). On the other hand, rabbits have been commonly used in preclinical trials for musculoskeletal research. However, there is a lack of
D Henrich et al.
Journal of tissue engineering and regenerative medicine, 10(10), E382-E396 (2014-03-29)
The Masquelet induced membrane technique for reconstructing large diaphyseal defects has been shown to be a promising clinical treatment, yet relatively little is known about the cellular, histological and biochemical make-up of these membranes and how they produce this positive
Jiehua Wu et al.
Stem cell research & therapy, 8(1), 278-278 (2017-12-15)
The pharmaceutical agent pentosan polysulfate (PPS) is known to induce proliferation and chondrogenesis of mesenchymal progenitor cells (MPCs) in vitro and in vivo. However, the mechanism(s) of action of PPS in mediating these effects remains unresolved. In the present report
Hongxiu Ning et al.
Biochemical and biophysical research communications, 413(2), 353-357 (2011-09-10)
Stro-1 is the best-known mesenchymal stem cell (MSC) marker. However, previous studies have observed its expression in the endothelium. In the present study we performed immunofluorescence (IF) staining for Stro-1, using endothelial marker vWF as reference. In the liver, both
Homing of in vitro expanded Stro-1- or Stro-1+ human mesenchymal stem cells into the NOD/SCID mouse and their role in supporting human CD34 cell engraftment.
Bensidhoum, M; Chapel, A; Francois, S; Demarquay, C; Mazurier, C; Fouillard, L; Bouchet et al.
Blood null
A Calarco et al.
Journal of dental research, 94(8), 1099-1105 (2015-05-01)
Fluoride-releasing restorative dental materials can be beneficial to remineralize dentin and help prevent secondary caries. However, the effects of fluoride release from dental materials on the activity of dental pulp stem cells are not known. Here we investigate whether different
Mesenchymal Stem Cell Marker Stro-1 is a 75kd Endothelial Antigen
Hongxiu N, et al.
Biochemical and Biophysical Research Communications, 413(2), 353-357 (2011)
P Kémoun et al.
Tissue & cell, 39(4), 257-266 (2007-07-31)
Bone morphogenetic proteins (BMPs) and BMP receptors (BMPRs) are known to regulate the development of calcified tissues by directing mesenchymal precursor cells differentiation. However, their role in the formation of tooth-supporting tissues remains unclear. We investigated the distribution pattern of
Identification of Stromal Cell Precursors in Human Bone Marrow by a Novel Monoclonal Antibody, STRO-1
Simmons P J, et al.
Blood, 78(1), 55-62 (1991)
Identification of Stromal Cell Precursors in Human Bone Marrow by a Novel Monoclonal Antibody, STRO-1
Paul JS and Simmons and Beverly TS
Blood, 78(1), 55- 62 (1991)
Yi Shen et al.
International orthopaedics, 36(4), 879-886 (2011-11-04)
A successful osseointegration relies on the interplay of implant surface and surrounding bone marrow cells. This study was undertaken to investigate the impact of age and gender on the bone marrow composition. Bone marrow aspirates were obtained from the discarded
Identification of stromal cell precursors in human bone marrow by a novel monoclonal antibody, STRO-1
Simmons, P J and Torok-Storb, B
Blood, 78, 55-62 (1991)
Titikan Laothumthut et al.
Clinical oral investigations, 19(2), 261-270 (2014-06-14)
For dental treatment, dentin regeneration is required after a tooth injury with dental pulp exposure. The effects of the water-soluble matrix (WSM) extracted from the nacreous layer of the bivalve Pinctada maxima on human dental pulp cells in vitro were
Xuechao Yang et al.
Tissue engineering, 13(11), 2803-2812 (2007-09-11)
Dental pulp stem cells harbor great potential for tissue-engineering purposes. However, previous studies have shown variable results, and some have reported only limited osteogenic and odontogenic potential.Because bone morphogenetic proteins (BMPs) are well-established agents to induce bone and dentin formation,in
Stuart I Hodgetts et al.
Cell transplantation, 22(3), 393-412 (2012-09-26)
This study aimed to determine the potential of purified (Stro-1(+)) human mesenchymal precursor cells (hMPCs) to repair the injured spinal cord (SC) after transplantation into T-cell-deficient athymic RNU nude rats following acute moderate contusive spinal cord injury (SCI). hMPCs were
S K Brusnahan et al.
Mechanisms of ageing and development, 131(11-12), 718-722 (2010-11-03)
Hematological deficiencies increase with aging leading to anemias, reduced hematopoietic stress responses and myelodysplasias. This study tested the hypothesis that side population hematopoietic stem cells (SP-HSC) would decrease with aging, correlating with IGF-1 and IL-6 levels and increases in bone
Human mesenchymal precursor cells (Stro-1+) from spinal cord injury patients improve functional recovery and tissue sparing in an acute spinal cord injury rat model
Hodgetts SI, et al.
Cell Transplantation, 22(3), 393-412 (2013)
C Martínez et al.
Journal of dental research, 90(4), 483-488 (2011-03-29)
Regulation of cell renewal in the periodontium is a critical cell function that has not been clarified. Sonic hedgehog (Shh) is a secreted signaling molecule that plays a key role during development and adult tissue homeostasis. In the present study
Gerald J Atkins et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 18(6), 1088-1098 (2003-06-24)
Human osteoblast phenotypes that support osteoclast differentiation and bone formation are not well characterized. Osteoblast differentiation markers were examined in relation to RANKL expression. RANKL expression was induced preferentially in immature cells. These results support an important link between diverse
Stan Gronthos et al.
Stem cells and development, 18(9), 1253-1262 (2009-03-31)
Mesenchymal stromal cells (MSCs) and their precursor cells (MPCs) can proliferate and differentiate into multiple mesodermal and some ectodermal and endodermal tissues. Culture-expanded MSCs are currently being evaluated as a possible cell therapy to replace/repair injured or diseased tissues. While
Shawn P Grogan et al.
Arthritis research & therapy, 11(3), R85-R85 (2009-06-09)
Recent findings suggest that articular cartilage contains mesenchymal progenitor cells. The aim of this study was to examine the distribution of stem cell markers (Notch-1, Stro-1 and VCAM-1) and of molecules that modulate progenitor differentiation (Notch-1 and Sox9) in normal
Vincenzo Lionetti et al.
The Journal of biological chemistry, 285(13), 9949-9961 (2010-01-26)
Possible cardiac repair by adult stem cell transplantation is currently hampered by poor cell viability and delivery efficiency, uncertain differentiating fate in vivo, the needs of ex vivo cell expansion, and consequent delay in transplantation after the onset of heart
Lucyene Miguita et al.
Cell and tissue banking, 21(1), 31-46 (2019-12-07)
Dental stem cells have many applications in medicine, dentistry and stem cell biology in general due to their easy accessibility and low morbidity. A common surgical manoeuvre after a tooth extraction is the dental socket curettage which is necessary to
Janos Kanczler et al.
Methods in molecular biology (Clifton, N.J.), 1914, 53-70 (2019-02-08)
In this chapter, we describe techniques for the isolation and characterisation of skeletal stem cells from human bone marrow. The methods for enrichment of STRO-1+ and STRO-4+ cells using magnetic activated cell sorting are described and we also detail techniques
F Chmilewsky et al.
Journal of dental research, 92(6), 532-539 (2013-04-23)
It recently became evident that activation of the complement system also contributes to tissue regeneration after infection/injury. The complement-derived fragment C5a induces vascular modifications and attracts cells expressing its receptor (C5aR/CD88) to the site of infection and tissue injury. Besides
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