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Showing 1-28 of 28 results for "STS0214" within Papers
Myriam Chentouf et al.
Journal of immunology (Baltimore, Md. : 1950), 179(1), 409-420 (2007-06-21)
The biological effects of rIgG(1) 13B8.2, directed against the CDR3-like loop on the D1 domain of CD4, are partly due to signals that prevent NF-kappaB nuclear translocation, but the precise mechanisms of action, particularly at the level of membrane proximal
R B Shah et al.
International journal of pharmaceutics, 341(1-2), 189-194 (2007-05-25)
In the present work, a novel application of ultrasonic measurements is detailed to characterize nano-emulsion formulations as a part of the overall Quality by Design (QbD) goal. Ultrasonic resonator technology (URT) was utilized to measure sound velocity and absorption of
María Vergara-Barberán et al.
Journal of agricultural and food chemistry, 59(20), 10775-10780 (2011-09-13)
A method for the determination of fatty acids in vegetable oils by capillary electrophoresis with indirect UV-vis detection has been developed. The separation of fatty acids was optimized in terms of Brij surfactant nature and concentration and organic modifier (2-propanol)
Gladious Naguib El-Hadidy et al.
Drug development and industrial pharmacy, 38(1), 64-72 (2011-06-24)
This work was undertaken to investigate microemulsion (ME) as a topical delivery system for the poorly water-soluble voriconazole. Different ME components were selected for the preparation of plain ME systems with suitable rheological properties for topical use. Two permeation enhancers
Woraporn Sukhumavasi et al.
Journal of immunology (Baltimore, Md. : 1950), 181(5), 3464-3473 (2008-08-21)
TLR adaptor MyD88 activation is important in host resistance to Toxoplasma gondii during i.p. infection, but the function of this signaling pathway during oral infection, in which mucosal immunity assumes a predominant role, has not been examined. In this study
Ji Won Park et al.
The Biochemical journal, 464(2), 241-249 (2014-09-23)
Cytochrome P450 (P450) function is dependent on the ability of these enzymes to successfully interact with their redox partners, NADPH-cytochrome P450 reductase (CPR) and cytochrome b5, in the endoplasmic reticulum (ER). Because the ER is heterogeneous in lipid composition, membrane
Majid Tabbakhian et al.
International journal of pharmaceutics, 323(1-2), 1-10 (2006-07-14)
Finasteride is indicated orally in the treatment of androgenetic alopecia and some other pilosebaceous unit (PSU) disorders. We wished to investigate whether topical application of finasteride-containing vesicles (liposomes and niosomes) could enhance drug concentration at the PSU, as compared to
Doaa Ahmed El-Setouhy et al.
The Journal of pharmacy and pharmacology, 62(1), 25-34 (2010-08-21)
The objective of this study was to improve systemic delivery of the highly analgesic ketorolac trometamol (ketorolac tromethamine) via the transdermal route, through cost-effective topical formulations, to avoid most of the problems associated with ketorolac trometamol therapy. In-vitro release behaviour
Prapaporn Boonme et al.
AAPS PharmSciTech, 7(2), E45-E45 (2006-06-27)
This research was aimed to characterize microemulsion systems of isopropyl palmitate (IPP), water, and 2:1 Brij 97 and 1-butanol by different experimental techniques. A pseudoternary phase diagram was constructed using water titration method. At 45% wt/wt surfactant system, microemulsions containing
Yash Kapoor et al.
International journal of pharmaceutics, 361(1-2), 222-229 (2008-06-26)
Cyclosporine A (CyA) is an immunosuppressant drug that is used for treating a variety of ocular diseases and disorders. CyA is commonly delivered via eye drops, which is highly inefficient due to a low bioavailability of less than 5%. The
Yash Kapoor et al.
Journal of colloid and interface science, 322(2), 624-633 (2008-03-25)
Surfactants are commonly incorporated into hydrogels to increase solute loading and attenuate the release rates. In this paper we focus on understanding and modeling the mechanisms of both surfactant and drug transport in hydrogels. Specifically, we focus on Brij 98
Jingling Tang et al.
Biomacromolecules, 14(2), 424-430 (2013-01-15)
Multidrug resistance (MDR) is a major barrier to the chemotherapy treatment of many cancers. However, some nonionic surfactants, for example, Brij, have been shown to restore the sensitivity of MDR cells to such drugs. The aim of this study was
Chuanyu Yang et al.
PloS one, 10(7), e0133826-e0133826 (2015-07-25)
Huanglongbing (HLB) is the most serious disease affecting the citrus industry worldwide to date. The causal agent, Candidatus Liberibacter asiaticus (Las), resides in citrus phloem, which makes it difficult to effectively treat with chemical compounds. In this study, a transcuticular
Carles Gil et al.
Biochemical and biophysical research communications, 348(4), 1334-1342 (2006-08-22)
Although the high presence of cholesterol in nerve terminals is well documented, specific roles of this lipid in transmitter release have remained elusive. Since cholesterol is a highly enriched component in the membrane microdomains known as lipid rafts, it is
Xi Chen et al.
Biochimica et biophysica acta, 1788(2), 477-483 (2009-01-03)
The size and the bilayer thickness of detergent-resistant membranes isolated from rat brain neuronal membranes using Triton X-100 or Brij 96 in buffers with or without the cations, K+/Mg2+ at a temperature of either 4 degrees C or 37 degrees
Jia-You Fang et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 67(1), 67-75 (2007-02-27)
Acoustically active lipospheres (AALs) were prepared using perfluorocarbons and coconut oil as the cores of inner phase. These AALs were stabilized using coconut oil and phospholipid coatings. A lipophilic antioxidant, resveratrol, was the model drug loaded into the AALs. AALs
Sergey Filippov et al.
Langmuir : the ACS journal of surfaces and colloids, 24(17), 9295-9301 (2008-08-09)
In this work we report a new type of pH-responsive micelle-like nanoparticle. Reversible nanoscale structures are formed in solutions of a pH-sensitive hydrophobic polyelectrolyte, poly( N-methacryloyl- l-valine) or poly( N-methacryloyl- l-phenylalanine), and nonionic surfactant (Brij 98) in the presence of
Sang-Chul Shin et al.
Pharmaceutical development and technology, 12(5), 429-436 (2007-10-27)
To increase the skin permeation of quinupramine through the rat skin, different types of enhancers were added to an ethylene-vinyl acetate (EVA) matrix containing 2% quinupramine. The effects of the enhancers on the level of quinupramine permeation through the skin
Claudia Salerno et al.
Pakistan journal of pharmaceutical sciences, 26(1), 189-193 (2012-12-25)
The aim of this work was to evaluate water-lecithin-dispersions (WLDs) as carriers for amphotericin B (AmB) and to compare the drug solubility in WLDs and O/W lecithin-based submicron emulsions (SMEs) in order to evaluate the influence of lecithin content on
K Rieber et al.
Biochimica et biophysica acta, 1768(5), 1050-1058 (2007-02-16)
The subject of this report was to investigate headgroup hydration and mobility of two types of mixed lipid vesicles, containing nonionic surfactants; straight chain Brij 98, and polysorbat Tween 80, with the same number of oxyethylene units as Brij, but
Marina Shevachman et al.
Drug development and industrial pharmacy, 34(4), 403-412 (2008-04-11)
Enhanced systemic absorption in vivo and percutaneous penetration in vitro was demonstrated after transdermal administration of diclofenac sodium formulated in U-type microemulsion. Diclofenac sodium was solubilized in a typical four-component system consisting of an oil, polyoxyethylene-10EO-oleyl alcohol (Brij 96V) as
Varaporn Buraphacheep Junyaprasert et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 10(3), 288-298 (2007-08-31)
To characterize the physicochemical properties of drug-loaded oil-in-water (o/w) and water-in-oil (w/o) Brij 97-based microemulsions in comparison to their blank counterparts and to investigate the influence of microemulsion type on in vitro skin permeation of model hydrophobic drugs and their
Gurpreet Kaur et al.
Langmuir : the ACS journal of surfaces and colloids, 28(29), 10640-10652 (2012-06-23)
Microemulsions are important formulations in cosmetics and pharmaceutics and one peculiarity lies in the so-called "phase inversion" that takes place at a given water-to-oil concentration ratio and where the average curvature of the surfactant film is zero. In that context
Lucia Montenegro et al.
International journal of pharmaceutics, 434(1-2), 169-174 (2012-06-05)
Idebenone (IDE), a synthetic derivative of ubiquinone, shows a potent antioxidant activity that could be beneficial in the treatment of skin oxidative damages. In this work, the feasibility of targeting IDE into the upper layers of the skin by topical
Ross A Kennedy et al.
AAPS PharmSciTech, 8(1), 25-25 (2007-04-06)
The aim of this work was to investigate the influence of some non-ionic surfactants, Tween 80 and Brij 98, on the viscosity and flow behavior of a commercial montmorillonite clay, Veegum Granules. The effect of different concentrations of the surfactants
Ahmed S Zidan et al.
International journal of pharmaceutics, 332(1-2), 55-63 (2006-12-16)
Quality by design (QBD) refers to the achievement of certain predictable quality with desired and predetermined specifications. A very useful component of the QBD is the understanding of factors and their interaction effects by a desired set of experiments. The
Jessica Phelps et al.
Colloids and surfaces. B, Biointerfaces, 87(2), 391-398 (2011-06-28)
In this study, fluid precursor formulations for subcutaneous injection and in situ formation of hexagonal phase gels upon water absorption were developed as a strategy to sustain the release of naltrexone, a drug used for treatment of drug addiction. Precursor
Maria E N P Ribeiro et al.
International journal of pharmaceutics, 436(1-2), 631-635 (2012-07-31)
The aim of this study was to investigate the potential of selected Brij non-ionic surfactants for enhancing the solubility of poorly water-soluble drugs. Griseofulvin was selected as a model drug candidate enabling comparisons to be made with the solubilisation capacities
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