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Showing 1-30 of 54 results for "T-043" within Papers
Fucui Ma et al.
Toxicology and applied pharmacology, 282(1), 68-76 (2014-12-03)
Both genetic and environmental factors contribute to neurodegenerative disorders. In a large number of neurodegenerative diseases (for example, Alzheimer's disease (AD)), patients do not carry the mutant genes. Other risk factors, for example the environmental factors, should be evaluated. 17β-trenbolone
D Marzin
Annales de recherches veterinaires. Annals of veterinary research, 22(3), 257-262 (1991-01-01)
The mutagenicity of trenbolone, a synthetic androgen, was studied in a number of genotoxicity tests using in vitro and in vivo systems for gene mutations, chromosomal mutations and primary DNA damage demonstration. Only 2 tests were found to be positive
Jinqing Jiang et al.
Journal of food science, 77(4), T63-T69 (2012-04-21)
This paper presents the generation of monoclonal antibodies (mAbs) with high specificity against 19-nortestosterone (NT) through cell fusion procedures, and the development of mAb-based heterologous direct competitive enzyme-linked immunoabsorbent assay (dcELISA) methods to detect NT residue using one of these
Shen Qu et al.
Science (New York, N.Y.), 342(6156), 347-351 (2013-09-28)
Trenbolone acetate (TBA) is a high-value steroidal growth promoter often administered to beef cattle, whose metabolites are potent endocrine-disrupting compounds. We performed laboratory and field phototransformation experiments to assess the fate of TBA metabolites and their photoproducts. Unexpectedly, we observed
Jed A Parker et al.
Talanta, 99, 238-246 (2012-09-13)
Studies demonstrate that exposure to steroid hormones in receiving waters can adversely impact reproduction of aquatic organisms. In particular, exogenous steroid hormones widely used as growth promoters in animal agriculture are of high concern, yet no gas chromatography-tandem mass spectrometry
Irmgard Riedmaier et al.
Analytical chemistry, 84(15), 6863-6868 (2012-08-07)
The abuse of anabolic substances in animal husbandry is forbidden within the EU and well controlled by detecting substance residues in different matrices. The application of newly designed drugs or substance cocktails represents big problems. Therefore developing sensitive test methods
K Kongsuwan et al.
Domestic animal endocrinology, 43(1), 67-73 (2012-04-17)
Implantation of trenbolone acetate (TBA) in conjunction with estradiol-17β (E(2)) increases growth, feed conversion efficiency, and carcass leanness in cattle. Our previous study in Brahman steers suggested that the neuropeptide hormone oxytocin (OXT) may be involved in increasing muscle growth
Joshua F Yarrow et al.
Steroids, 75(6), 377-389 (2010-02-09)
Recently, the development of selective androgen receptor modulators (SARMs) has been suggested as a means of combating the deleterious catabolic effects of hypogonadism, especially in skeletal muscle and bone, without inducing the undesirable androgenic effects (e.g., prostate enlargement and polycythemia)
Kevin Flynn et al.
Environmental toxicology and chemistry, 32(6), 1344-1353 (2013-02-21)
Various aquatic bioassays using one of several fish species have been developed or are in the process of being developed by organizations like the US Environmental Protection Agency and the Office of Economic Cooperation and Development for testing potential endocrine-disrupting
E C Titgemeyer et al.
Journal of animal science, 90(10), 3515-3526 (2012-08-02)
Urea kinetics were measured in 2 experiments, with treatments designed to change protein deposition by the animal. Our hypothesis was that increased protein deposition by cattle (Bos taurus) would reduce urea production and recycling to the gastrointestinal tract. Urea kinetics
F Palm et al.
Theriogenology, 79(1), 59-68 (2012-11-06)
In most mammalian species, progestins have a major function in maintaining pregnancy. In humans, the physiologic initiation of parturition bears similarities with inflammatory processes and anti-inflammatory effects of progestins have been suggested to postpone birth until term. To examine if
K Y Chung et al.
Journal of animal science, 90(5), 1421-1427 (2012-05-11)
Twenty crossbred yearling steers (421 kg) were used to evaluate the effects of implanting with trenbolone acetate (TBA; 120 mg), estradiol-17β (E(2); 25.7 mg), and a combination (120 mg of TBA and 24 mg of E(2)) on adipogenic and myogenic
The dark side of beauty: acne fulminans induced by anabolic steroids in a male bodybuilder.
Sophie L Kraus et al.
Archives of dermatology, 148(10), 1210-1212 (2012-10-17)
Todd R Robeck et al.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 43(2), 296-308 (2012-07-12)
Progesterone production is essential for growth and development of the conceptus during pregnancy. Abnormal development of the corpus luteum (CL) after conception can result in early embryonic loss or fetal abortion. Routine monitoring of bottlenose dolphin (Tursiops truncatus) pregnancy after
Joshua F Yarrow et al.
PloS one, 7(10), e47315-e47315 (2012-10-17)
Several endocrine factors, including sex-steroid hormones are known to influence adiponectin secretion. Our purpose was to evaluate the influence of testosterone and of the synthetic non-aromatizable/non-5α reducible androgen 17β-hydroxyestra-4,9,11-trien-3-one (trenbolone) on circulating adiponectin and adiponectin protein expression within visceral fat.
Ecology. Zombie endocrine disruptors may threaten aquatic life.
Erik Stokstad
Science (New York, N.Y.), 341(6153), 1441-1441 (2013-09-28)
D A King et al.
Journal of animal science, 90(7), 2410-2423 (2012-07-07)
The potential interaction of growth-promoting implants and genetic markers previously reported to be associated with growth, carcass traits, and tenderness was evaluated. Two implant protocols were applied to subsets of steers (n = 383) and heifers (n = 65) that
B Kemp et al.
Reproduction in domestic animals = Zuchthygiene, 47 Suppl 4, 320-326 (2012-08-01)
Normally, sows are in anoestrus during lactation and start their new cycle at the day of weaning. Modern hybrid primiparous sows that suckle large numbers of piglets may lose substantial amounts of body reserves during lactation. This compromises follicle development
Yohana M Velasco-Santamaría et al.
Environmental pollution (Barking, Essex : 1987), 178, 189-196 (2013-04-16)
The interaction of xenobiotics is common in aquatic ecosystems; therefore, we wanted to evaluate if trenbolone (TB) modulates the effects of 17α-ethinylestradiol (EE2). Male eelpout (Zoarces viviparus) were exposed to 5 ng L(-1) EE2 continuously for 19 d (EE2-C) or discontinuously (11 d, EE2-D)
Erica K Brockmeier et al.
Aquatic toxicology (Amsterdam, Netherlands), 128-129, 163-170 (2013-01-15)
The Eastern and Western mosquitofish (Gambusia holbrooki and G. affinis) are potential bioindicator organisms for endocrine disruptors. Male mosquitofish have an elongated anal fin (gonopodium) used for internal fertilization whose formation is driven by androgens. Normal female mosquitofish have a
Bushra Khan et al.
Chemosphere, 89(11), 1443-1449 (2012-07-17)
The increasing size of concentrated animal feeding operations has led to a concomitant increase in the land-application of manure, which has spawned research on the concentrations and environmental risk assessment of natural and synthetic hormones in animal manures. 17β-Trenbolone acetate
D R Ekman et al.
Environmental science & technology, 46(17), 9673-9680 (2012-08-01)
Widespread environmental contamination by bisphenol A (BPA) has created the need to fully define its potential toxic mechanisms of action (MOA) to properly assess human health and ecological risks from exposure. Although long recognized as an estrogen receptor (ER) agonist
R M Cleale et al.
Journal of animal science, 90(13), 5056-5066 (2012-10-27)
Synovex Plus (SP) is a product that delivers 28 mg of estradiol benzoate (EB) and 200 mg of trenbolone acetate (TBA). We studied the impact of a polymeric, porous coating on SP implants (CSP) to prolong release of EB and
Sean C McCoy et al.
Bone, 51(4), 667-673 (2012-07-31)
Testosterone enanthate (TE) administration attenuates bone loss in orchiectomized (ORX) rats. However, testosterone administration may increase risk for prostate/lower urinary tract related adverse events and polycythemia in humans. Trenbolone enanthate (TREN) is a synthetic testosterone analogue that preserves bone mineral
Allen W Olmstead et al.
Environmental toxicology and chemistry, 31(10), 2391-2398 (2012-08-01)
Trenbolone is an androgen agonist used in cattle production and has been measured in aquatic systems associated with concentrated animal-feeding operations. In this study, the authors characterized the effects of aqueous exposure to 17β-trenbolone during larval Xenopus tropicalis development. Trenbolone
R D Munson et al.
Journal of animal science, 90(11), 4037-4041 (2012-11-14)
Auction-derived feeder calves (n = 1,601; initial BW = 273.5 ± 4.7 kg) were used to examine effects of delayed administration of the initial steroid implant on health, performance, and carcass characteristics of feedlot cattle. Steers were procured from multiple
R M Cleale et al.
Journal of animal science, 91(2), 970-977 (2013-01-12)
Trials were conducted with beef heifers at 4 sites to evaluate feedlot performance and carcass characteristics in response to implants containing 14 mg estradiol benzoate and 100 mg trenbolone acetate (EB/TBA; Synovex Choice, Zoetis LLC, New York, NY), 14 mg
A Grégoire et al.
Theriogenology, 78(4), 842-847 (2012-05-26)
The aim of this work was to look for a simple method to obtain synchronized ovulation in guinea pigs under farming conditions while respecting animal welfare. The luteolytic activity of three different prostaglandins F2alpha (PGF2α) analogs (D-cloprostenol, D,L-cloprostenol and luprostiol)
B R Blackwell et al.
Ecotoxicology and environmental safety, 85, 110-114 (2012-09-07)
Manure from livestock feeding operations is commonly applied to agricultural fields as an alternative to commercial fertilizers. Trenbolone acetate (TbA) is a synthetic growth promoter frequently utilized in beef cattle feeding operations. Metabolites of TbA can be present in manure
Shan Liu et al.
Environmental pollution (Barking, Essex : 1987), 170, 190-201 (2012-07-28)
Fate and occurrence of fourteen androgens, four estrogens, five glucocorticoids and five progestagens were investigated in three swine farms and three dairy cattle farms with different farming scales and wastes disposal systems in China. Twenty-one, 22, and 12 of total
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