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T cell receptor delta diversity 1
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Showing 1-30 of 639 results for "T cell receptor delta diversity 1" within Papers
Jan Kisielow et al.
Blood, 118(25), 6591-6600 (2011-10-25)
In addition to adaptive T cells, the thymus supports the development of unconventional T cells such as natural killer T (NKT) and CD8αα intraepithelial lymphocytes (IELs), which have innate functional properties, particular antigenic specificities, and tissue localization. Both conventional and
Christopher L Reardon
Immunogenetics, 61(10), 673-687 (2009-09-17)
T cell receptor (TCR) and B cell receptors (BCR) junctions, also known as the CDR3, are where the V, D, and J gene segments converge, coding for a loop structure important for contacting ligands. J segments contribute to the formation
T Ohteki et al.
European journal of immunology, 26(2), 351-355 (1996-02-01)
T cell factor-1 (Tcf-1) is a transcription factor that binds to a sequence motif present in several T cell-specific enhancer elements. In Tcf-1-deficient (Tcf-1-/-) mice, thymocyte development is partially blocked at the transition from the CD4-8+ immature single-positive stage to
Arkadiusz Miazek et al.
European journal of immunology, 39(9), 2596-2605 (2009-08-25)
Linker for activation of T cells (LAT) is an adaptor molecule indispensable for development of alphabeta and gammadelta T lymphocytes. Surprisingly, using a new model of LAT-deficient mice we found that despite arrested thymic development, a discrete population of cells
S J Seo et al.
The Journal of investigative dermatology, 116(6), 880-885 (2001-06-16)
The physiologic role of gamma delta-T-cell-receptor-bearing cells and the T cell receptor ligands that they recognize is still poorly understood. Previous studies have suggested that one possible antigen for gamma delta-TCR(+) cells is the random copolymer poly-glutamic acid-tyrosine (poly-Glu-Tyr), because
V Azuara et al.
European journal of immunology, 28(11), 3456-3467 (1998-12-08)
Thy-1dull gammadelta T cells are an unusual subset of mature TCRgammadelta T cells characterized by their highly restricted TCR repertoire. In DBA/2 mice, they predominantly express the product of the Vgamma1 gene together with that of a member of the
Q Liang et al.
Clinical and experimental immunology, 203(1), 55-65 (2020-10-06)
Semi-allogeneic embryos are not rejected by the maternal immune system due to maternal-fetal immune tolerance. Progesterone (P) receptor (PR)-expressing γδ T cells are present in healthy pregnant women. In the presence of P, these cells secrete an immunomodulatory protein called
Sarah E Byeseda et al.
The American journal of pathology, 175(2), 571-579 (2009-07-18)
Wound healing and inflammation are both significantly reduced in mice that lack gammadelta T cells. Here, the role of epithelial intercellular adhesion molecule-1 (ICAM-1) in gammadelta T cell migration in corneal wound healing was assessed. Wild-type mice had an approximate
J W Huleatt et al.
Immunity, 5(3), 263-273 (1996-09-01)
Development of the mucosal immune system was examined in mice with partial loss of expression of ICAM-1 or CD18. Profound effects on Peyer's patch (PP), lamina propria (LP), and intraepithelial lymphocyte (IEL) T cell populations were observed in mutant mice.
K E Hedin et al.
Journal of immunology (Baltimore, Md. : 1950), 159(11), 5431-5440 (1998-04-21)
Recent molecular evidence points to transient and/or stage-specific expression of delta- and kappa-opioid receptors by thymic and peripheral T lymphocytes. Since medical treatments or stress commonly increase opioid levels, it is important to understand the mechanisms by which opioids affect
Maria F S Costa et al.
European journal of immunology, 42(5), 1250-1260 (2012-04-28)
Herein, we provide evidence that during allergic inflammation, CCL25 induces the selective migration of IL-17(+) γδ T cells mediated by α(4) β(7) integrin. Intrapleural injection of CCL25 into ovalbumin (OVA)-immunized C57BL/6 mice triggered the accumulation of γδ T lymphocytes expressing
BMI1 as oncogenic candidate in a novel TCRB-associated chromosomal aberration in a patient with TCRgammadelta+ T-cell acute lymphoblastic leukemia.
N S D Larmonie et al.
Leukemia, 22(6), 1266-1267 (2007-11-09)
Jieming Zeng et al.
PloS one, 14(5), e0216815-e0216815 (2019-05-10)
Using induced pluripotent stem cells (iPSCs) to derive chimeric antigen receptor-modified T (CAR-T) cells has great industrial potential. A previous study used αβ T cell-derived CAR-modified iPSCs to produce CAR-T cells. However, these αβ T cells are restricted to autologous
L Ardouin et al.
The Journal of experimental medicine, 187(1), 105-116 (1998-01-31)
The pre-T cell receptor (TCR) associates with CD3-transducing subunits and triggers the selective expansion and maturation of T cell precursors expressing a TCR-beta chain. Recent experiments in pre-Talpha chain-deficient mice have suggested that the pre-TCR may not be required for
Dimpu Gogoi et al.
Journal of immunology (Baltimore, Md. : 1950), 192(5), 2054-2062 (2014-02-04)
Notch signaling plays a pivotal role in cell fate decision and lineage commitment of lymphocytes. Although the role of Notch in CD4(+) and CD8(+) αβ T cells is well documented, there are no reports on how Notch signaling regulates effector
Delphine Guy-Grand et al.
The Journal of experimental medicine, 197(3), 333-341 (2003-02-05)
In the absence of thymopoiesis, T lymphocytes are nevertheless present, mainly in the gut epithelium. Ontogeny of the extrathymic pathway and the extent of its involvement in euthymic mice are controversial. These questions have been addressed by assessing the expression
Christoph Kleinschnitz et al.
Blood, 115(18), 3835-3842 (2010-03-11)
T cells contribute to the pathophysiology of ischemic stroke by yet unknown mechanisms. Mice with transgenic T-cell receptors (TCRs) and mutations in costimulatory molecules were used to define the minimal immunologic requirements for T cell-mediated ischemic brain damage. Stroke was
Laura Maggi et al.
European journal of immunology, 40(8), 2174-2181 (2010-05-21)
We have previously shown that human Th17 lymphocytes are characterized by the selective expression of IL-23 receptor (IL-23R), CCR6, CD161, and the transcription factor retinoic acid-related orphan receptor C (RORC), and originate from a CD161(+)CD4(+) naïve T-cell precursor in response
Anna C Belkina et al.
Frontiers in immunology, 9, 2783-2783 (2018-12-21)
Even with effective viral control, HIV-infected individuals are at a higher risk for morbidities associated with older age than the general population, and these serious non-AIDS events (SNAEs) track with plasma inflammatory and coagulation markers. The cell subsets driving inflammation
Gérard Eberl et al.
Science (New York, N.Y.), 305(5681), 248-251 (2004-07-13)
Intestinal intraepithelial T lymphocytes (IELs) are likely to play a key role in host mucosal immunity and, unlike other T cells, have been proposed to differentiate from local precursors rather than from thymocytes. We show here that IELs expressing the
Nadya al Yacoub et al.
The Journal of investigative dermatology, 128(8), 1940-1949 (2008-02-29)
Peroxisome proliferator-activated receptor beta/delta (PPARdelta) is a nuclear hormone receptor regulating diverse biological processes, including beta-oxidation of fatty acid and epithelial cell differentiation. To date, the role of PPARdelta in the immune system has not been thoroughly studied. Here, we
P Del Porto et al.
The Journal of experimental medicine, 173(6), 1339-1344 (1991-06-01)
We have recently generated a series of gamma/delta T cell clones able to kill, after in vitro immunization, an Epstein-Barr Virus-transformed B cell line (designated E418) in a non-major histocompatibility complex-requiring fashion. A monoclonal antibody, termed anti-10H3, produced against E418
Zhijie Li et al.
The American journal of pathology, 171(3), 838-845 (2007-08-07)
Corneal epithelial abrasion in C57BL/6 mice induces an inflammatory response with peak accumulation of neutrophils in the corneal stroma within 12 hours. Platelets localize in the limbal vessels throughout the same time course as neutrophils and contribute to wound healing
Ferry Cornelissen et al.
Arthritis research & therapy, 11(6), R194-R194 (2009-12-19)
Interleukin (IL)-23 is essential for the development of various experimental autoimmune models. However, the role of IL-23 in non-autoimmune experimental arthritis remains unclear. Here, we examined the role of IL-23 in the non-autoimmune antigen-induced arthritis (AIA) model. In addition, the
Caroline E Sutton et al.
Immunity, 31(2), 331-341 (2009-08-18)
Th17 cells, CD4(+) T cells that secrete interleukin-17 (IL-17), are pathogenic in autoimmune diseases and their development and expansion is driven by the cytokines IL-6, TGF-beta, IL-21, IL-1, and IL-23. However, there are also innate sources of IL-17. Here, we
Laura Maggi et al.
European journal of immunology, 40(8), 2174-2181 (2010-05-21)
We have previously shown that human Th17 lymphocytes are characterized by the selective expression of IL-23 receptor (IL-23R), CCR6, CD161, and the transcription factor retinoic acid-related orphan receptor C (RORC), and originate from a CD161(+)CD4(+) naïve T-cell precursor in response
Jeong-su Do et al.
Blood, 113(25), 6361-6371 (2009-04-22)
Homeostatic mechanism by which peripheral T-cell subsets are maintained in vivo remains largely unknown. Using a T-cell proliferation model under lymphopenic settings, we now demonstrate that gammadelta T cells limit CD8 T-cell expansion but not the initial proliferation after transfer
Murielle Corvaisier et al.
Journal of immunology (Baltimore, Md. : 1950), 175(8), 5481-5488 (2005-10-08)
During analysis of CD8 T cells derived from ascites of a colon cancer patient, we isolated a Vgamma9Vdelta2 T cell clone showing strong reactivity against autologous tumor cell lines. This clone killed a large fraction of allogeneic colon carcinoma and
Alanna S Murday et al.
Immunology, 151(4), 385-394 (2017-03-28)
The study aimed to identify an immunoregulatory factor that restores the phosphoantigen response of Vγ9Vδ2
Heather J Melichar et al.
Science (New York, N.Y.), 315(5809), 230-233 (2007-01-16)
alphabeta and gammadelta T cells originate from a common, multipotential precursor population in the thymus, but the molecular mechanisms regulating this lineage-fate decision are unknown. We have identified Sox13 as a gammadelta-specific gene in the immune system. Using Sox13 transgenic
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