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Showing 1-30 of 152 results for "T0014000" within Papers
Tumor heterogeneity confounds and illuminates: a case for Darwinian tumor evolution.
Kornelia Polyak
Nature medicine, 20(4), 344-346 (2014-04-09)
JAMA patient page. Tamoxifen update.
Deborah Tolmach Sugerman
JAMA, 310(8), 866-866 (2013-08-29)
David S Paul et al.
Biochimica et biophysica acta, 1841(6), 880-887 (2014-03-19)
In mice with temporally-induced cardiac-specific deficiency of acyl-CoA synthetase-1 (Acsl1(H-/-)), the heart is unable to oxidize long-chain fatty acids and relies primarily on glucose for energy. These metabolic changes result in the development of both a spontaneous cardiac hypertrophy and
Liane M McGlynn et al.
European journal of cancer (Oxford, England : 1990), 50(2), 290-301 (2013-11-05)
Sirtuins comprise a family of genes involved in cellular stress, survival and damage responses. They have been implicated in a range of diseases including cancer, with most information pertaining to their function in tumourigenesis being derived from in vitro studies
Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy.
M Swiderska-Syn et al.
Gut, 63(8), 1333-1344 (2013-11-01)
Smoothened (SMO), a coreceptor of the Hedgehog (Hh) pathway, promotes fibrogenic repair of chronic liver injury. We investigated the roles of SMO+ myofibroblast (MF) in liver regeneration by conditional deletion of SMO in α smooth muscle actin (αSMA)+ cells after
Joel M Reid et al.
Cancer chemotherapy and pharmacology, 74(6), 1271-1278 (2014-10-17)
Reduced CYP2D6 metabolism and low Z-endoxifen (ENDX) concentrations may increase the risk of breast cancer recurrence in tamoxifen (TAM)-treated women. Little is known regarding the differences between TAM and ENDX murine pharmacokinetics or the effect of administration route on plasma
Mat Samuji et al.
Irish medical journal, 106(8), 246-246 (2013-11-29)
Tamoxifen has been shown to significantly reduce the risk of tumour recurrence in women with receptor positive breast cancer and has been used for chemoprevention in women with both non-invasive cancer and those with a high risk of developing breast
Maria Gloria Luciani-Torres et al.
Carcinogenesis, 36(1), 168-176 (2014-11-21)
Identification of early perturbations induced in cells from non-cancerous breast tissue is critical for understanding possible breast cancer risk from chemical exposure. We have demonstrated previously that exposure to the ubiquitous xenoestrogens, bisphenol A (BPA) and methyl paraben, promotes the
A molecular model for the mechanism of acquired tamoxifen resistance in breast cancer.
Fan P, Agboke FA, Cunliffe HE, et al.
European Journal of Cancer, 50(16), 2866-2876 (2014)
Should radiotherapy be omitted in women age 70 years or older with early breast cancer?
Orit Kaidar-Person et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(36), 4569-4569 (2013-11-06)
Philip M Spanheimer et al.
Annals of surgery, 259(4), 793-799 (2013-09-21)
We investigated directed therapy based on TFAP2C-regulated pathways to inform new therapeutic approaches for treatment of luminal breast cancer. TFAP2C regulates the expression of genes characterizing the luminal phenotype including ESR1 and RET, but pathway cross talk and potential for
Paroxetine approval.
Suzanne M Mahon et al.
The American journal of nursing, 114(1), 10-10 (2013-12-29)
Sercan Ergun et al.
Gene, 555(2), 377-381 (2014-12-03)
The most common malignancy in women is breast cancer. Drug resistance in the treatment of cancer still remains a major clinical concern. Resistance to tamoxifen is seen in half of the recurrences in breast cancer. The anti-estrogen tamoxifen gains agonistic
Manisha Palta et al.
Cancer, 121(2), 188-193 (2014-12-10)
The Cancer and Leukemia Group B (CALGB) 9343 randomized phase 3 trial established lumpectomy and adjuvant therapy with tamoxifen alone, rather than both radiotherapy and tamoxifen, as a reasonable treatment course for women aged >70 years with clinical stage I
Willemien van de Water et al.
Journal of the National Cancer Institute, 106(4), dju051-dju051 (2014-03-22)
Inclusion in trials is selective, and thus results may not be generalizable to the general population. The aim of this study was to investigate the external validity of randomized clinical trial outcomes for elderly breast cancer patients. We compared characteristics
Tiantian Cai et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(24), 10110-10122 (2013-06-14)
Atonal homolog1 (Atoh1) encodes a basic helix-loop-helix protein that is the first transcription factor to be expressed in differentiating hair cells. Previous work suggests that expression of Atoh1 in prosensory precursors is necessary for the differentiation and survival of hair
Simone Schrading et al.
Radiology, 271(1), 45-55 (2014-01-31)
To prospectively investigate the effects of two antihormonal medications, tamoxifen and aromatase inhibitor (AI), on the degree of background enhancement in breast magnetic resonance (MR) imaging. This institutional review board-approved study was performed in 40 postmenopausal women (mean age, 63
Annette Wilisch-Neumann et al.
Journal of cancer research and clinical oncology, 140(8), 1343-1352 (2014-05-13)
The purpose was to re-evaluate in cell culture models the therapeutic usefulness of some discussed chemotherapies or targeted therapies for meningiomas with a special emphasis on the role of the neurofibromatosis type 2 (NF2) tumor suppressor, which had been neglected
G Martelli et al.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 40(7), 805-812 (2014-04-29)
Our randomized trial found no survival advantage for axillary dissection (AD) compared observation only (no AD) in older patients with early breast cancer and a clinically negative axilla, indicating that AD is unnecessary. We compared characteristics and outcomes in out-trial
Margarida Sancho et al.
Developmental cell, 26(1), 19-30 (2013-07-23)
A fundamental question in developmental biology is whether there are mechanisms to detect stem cells with mutations that, although not adversely affecting viability, would compromise their ability to contribute to further development. Here, we show that cell competition is a
Ellen Lorange et al.
The Journal of reproductive medicine, 58(7-8), 344-346 (2013-08-21)
Both ectopic prostate tissue in the female genital tract and vaginal myofibroblastoma have rarely been reported in the literature. Tamoxifen use has been associated with the development of vaginal myofibroblastoma. A 76-year-old, multiparous woman who had taken tamoxifen for breast
C H Wilson et al.
Oncogene, 33(40), 4877-4880 (2014-03-26)
Reversibly switchable proteins are powerful tools with which to explore protein function in vitro and in vivo. For example, the activity of many proteins fused to the hormone-binding domain of the modified oestrogen receptor (ER(TAM)) can be regulated by provision
Lei Duan et al.
Cancer letters, 353(2), 290-300 (2014-07-30)
Autophagy is a mechanism of tamoxifen (TAM) resistance in ER-positive (ER+) breast cancer cells. In this study, we showed in ER+ MCF7 cells that 4-hydroxytamoxifen (4OHTAM) induced cellular nitric oxide (NO) that negatively regulates cellular superoxide (O2-) and cytotoxicity. 4OHTAM
Exemestane with ovarian suppression in premenopausal breast cancer.
Rowan T Chlebowski et al.
The New England journal of medicine, 371(14), 1358-1358 (2014-10-02)
Jen-Chung Ko et al.
Biochemical and biophysical research communications, 456(1), 506-512 (2014-12-10)
The anti-estrogen tamoxifen has been used worldwide as an adjuvant hormone therapeutic agent in the treatment of breast cancer. However, the molecular mechanism of tamoxifen-induced cytotoxicity in non-small cell lung cancer (NSCLC) cells has not been identified. Human MutS homolog
Kai Zheng et al.
Biochemical and biophysical research communications, 446(4), 990-996 (2014-03-25)
Herpes simplex virus type 1 (HSV-1) infection is very common worldwide and can cause significant health problems from periodic skin and corneal lesions to encephalitis. Appearance of drug-resistant viruses in clinical therapy has made exploring novel antiviral agents emergent. Here
Melanie Gerl et al.
Kidney international, 87(3), 557-563 (2014-09-18)
Genetic loss-of-function defects of connexin 40 in renal juxtaglomerular cells are associated with renin-dependent hypertension. The dysregulation of renin secretion results from an intrarenal displacement of renin cells and an interruption of the negative feedback control of renin secretion by
Joann V Pinkerton et al.
The Journal of steroid biochemistry and molecular biology, 142, 142-154 (2014-01-01)
Selective estrogen receptor modulators (SERMs) are synthetic non-steroidal agents which have varying estrogen agonist and antagonist activities in different tissues, most likely due to the receptor conformation changes associated with that SERM's binding and the subsequent effect on transcription. Clinical
Junzhi Wang et al.
Fitoterapia, 95, 93-101 (2014-03-19)
Hispolon was the main antitumor active ingredient in Phellinus sensu lato species. In order to confirm the dual regulating estrogenic ingredient and obtain more effective natural estrogen replacement drugs, hispolon was separated from Phellinus lonicerinus (Bond.) Bond. et sing. Hispolon
Noriaki Ono et al.
Nature cell biology, 16(12), 1157-1167 (2014-11-25)
The hallmark of endochondral bone development is the presence of cartilaginous templates, in which osteoblasts and stromal cells are generated to form mineralized matrix and support bone marrow haematopoiesis. However, the ultimate source of these mesenchymal cells and the relationship
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