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Showing 1-30 of 59 results for "T2780" within Papers
Anna Bianchi et al.
Cell cycle (Georgetown, Tex.), 9(8), 1647-1659 (2010-04-21)
Epithelial-mesenchymal-transition (EMT) in response to TGFβ contributes to normal development, wound healing and tumor progression. The present study provides evidence for a critical role of β5-integrin in the TGFβ-induced EMT and the tumorigenic potential of carcinoma cells. We show that
Pedro Martín-Acosta et al.
Acta pharmaceutica Sinica. B, 12(5), 2406-2416 (2022-06-02)
Target identification of bioactive compounds is important for understanding their mechanisms of action and provides critical insights into their therapeutic utility. While it remains a challenge, unbiased chemoproteomics strategy using clickable photoaffinity probes is a useful and validated approach for
Vertebrate tropomyosin: distribution, properties and function
Perry, S Victor
Journal of Muscle Research and Cell Motility, 22(1), 5-49 (2001)
Patrick Carlson et al.
Toxicological sciences : an official journal of the Society of Toxicology, 134(1), 83-91 (2013-04-11)
The zebrafish (Danio rerio) was used to investigate protein expression in the liver following arsenic exposure. Several disorders have been linked to arsenic exposure, including cancer, diabetes, and cardiovascular disease. The mechanisms of arsenic toxicity are poorly understood. Prior studies
Merja Joensuu et al.
Molecular biology of the cell, 25(7), 1111-1126 (2014-02-14)
The endoplasmic reticulum (ER) comprises a dynamic three-dimensional (3D) network with diverse structural and functional domains. Proper ER operation requires an intricate balance within and between dynamics, morphology, and functions, but how these processes are coupled in cells has been
Sandeep M Nalluri et al.
Journal of cellular physiology, 237(5), 2503-2515 (2022-03-01)
Epithelial-mesenchymal transition (EMT) is a physiological process that is essential during embryogenesis and wound healing and also contributes to pathologies including fibrosis and cancer. EMT is characterized by marked gene expression changes, loss of cell-cell contacts, remodeling of the cytoskeleton
Non-canonical Wnt signaling enhances differentiation of Sca1+/c-kit+ adipose-derived murine stromal vascular cells into spontaneously beating cardiac myocytes
Palpant N J, et al.
Journal of Molecular and Cellular Cardiology, 43(3), 362-370 (2007)
Megan Gervasi et al.
The Journal of cell biology, 196(5), 589-603 (2012-03-07)
The process of epithelial-mesenchymal transition (EMT) in response to transforming growth factor-β (TGF-β) contributes to tissue fibrosis, wound healing, and cancer via a mechanism that is not fully understood. This study identifies a critical role of JunB in the EMT
Nicole S Bryce et al.
Molecular biology of the cell, 14(3), 1002-1016 (2003-03-13)
The specific functions of greater than 40 vertebrate nonmuscle tropomyosins (Tms) are poorly understood. In this article we have tested the ability of two Tm isoforms, TmBr3 and the human homologue of Tm5 (hTM5(NM1)), to regulate actin filament function. We
CENP-A is essential for cardiac progenitor cell proliferation
McGregor M, et al
Cell Cycle, 13(5), 739-748 (2014)
Joyce C M Meiring et al.
Scientific reports, 9(1), 6504-6504 (2019-04-26)
The majority of actin filaments in human cells exist as a co-polymer with tropomyosin, which determines the functionality of actin filaments in an isoform dependent manner. Tropomyosin isoforms are sorted to different actin filament populations and in yeast this process
N J MacDonald et al.
The Journal of biological chemistry, 276(27), 25190-25196 (2001-05-04)
The mechanism of action of Endostatin, an endogenous inhibitor of angiogenesis and tumor growth, remains unknown. We utilized phage-display technology to identify polypeptides that mimic the binding domains of proteins with which Endostatin interacts. A conformed peptide (E37) was identified
Janiel M Shields et al.
Molecular and cellular biology, 22(7), 2304-2317 (2002-03-09)
We showed previously that activated Ras, but not Raf, causes transformation of RIE-1 epithelial cells, demonstrating the importance of Raf-independent pathways in mediating Ras transformation. To assess the mechanism by which Raf-independent effector signaling pathways contribute to Ras-mediated transformation, we
Chris Jopling et al.
Circulation, 126(25), 3017-3027 (2012-11-16)
Hypoxia plays an important role in many biological/pathological processes. In particular, hypoxia is associated with cardiac ischemia. which, although initially inducing a protective response, will ultimately lead to the death of cardiomyocytes and loss of tissue, severely affecting cardiac functionality.
Andrea Meixner et al.
Molecular & cellular proteomics : MCP, 10(1), M110-M110 (2010-09-30)
Mutations in human leucine-rich repeat kinase 2 (Lrrk2), a protein of yet unknown function, are linked to Parkinson's disease caused by degeneration of midbrain dopaminergic neurons. The protein comprises several domains including a GTPase and a kinase domain both affected
Elisa Belian et al.
PloS one, 10(6), e0125384-e0125384 (2015-06-06)
Adult cardiac stem cells (CSCs) express many endogenous cardiogenic transcription factors including members of the Gata, Hand, Mef2, and T-box family. Unlike its DNA-binding targets, Myocardin (Myocd)-a co-activator not only for serum response factor, but also for Gata4 and Tbx5-is
Tasha N Sims et al.
Cell, 129(4), 773-785 (2007-05-22)
The immunological synapse (IS) is a junction between the T cell and antigen-presenting cell and is composed of supramolecular activation clusters (SMACs). No studies have been published on naive T cell IS dynamics. Here, we find that IS formation during
Ewelina Jurewicz et al.
Scientific reports, 10(1), 12824-12824 (2020-08-01)
S100A6 is a low molecular weight Ca2+-binding protein belonging to the S100 family. Many reports indicate that in the cell S100A6 has an influence on the organization of actin filaments, but so far no direct interaction between S100A6 and actin
Tropomyosin-master regulator of actin filament function in the cytoskeleton
Gunning P W, et al.
Journal of Cell Science, 128(16), 2965-2974 (2015)
Ewelina Jurewicz et al.
Biochimica et biophysica acta, 1833(3), 761-766 (2012-12-26)
The CacyBP/SIP protein interacts with several targets, including actin. Since the majority of actin filaments are associated with tropomyosin, in this work we characterized binding of CacyBP/SIP to the actin-tropomyosin complex and examined the effects of CacyBP/SIP on actin filament
Galina Schevzov et al.
Bioarchitecture, 1(4), 135-164 (2011-11-10)
Tropomyosins are rod-like dimers which form head-to-tail polymers along the length of actin filaments and regulate the access of actin binding proteins to the filaments.1 The diversity of tropomyosin isoforms, over 40 in mammals, and their role in an increasing
M I Hamilton et al.
Clinical and experimental immunology, 99(3), 404-411 (1995-03-01)
Ulcerative colitis (UC) has a proposed autoimmune pathogenesis. A 40-kD antigen (P40) has been isolated from UC colon, bound to immunoglobulin. Tropomyosin has been reported as the target antigen of a MoAb (7E12H12) raised against P40. We set out to
Decoding the IGF1 signaling gene regulatory network behind alveologenesis from a mouse model of bronchopulmonary dysplasia.
Gao, et al.
eLife, 11 (2023)
K Takenaga et al.
The Journal of cell biology, 124(5), 757-768 (1994-03-01)
The cDNA coding for mouse fibroblast tropomyosin isoform 2 (TM2) was placed into a bacterial expression vector to produce a fusion protein containing glutathione-S-transferase (GST) and TM2 (GST/TM2). Glutathione-Sepharose beads bearing GST/TM2 were incubated with [35S]methionine-labeled NIH 3T3 cell extracts
Lisa M Domke et al.
Cell and tissue research, 375(2), 451-482 (2018-12-29)
The testes of sexually mature males of six mammalian species (men, bulls, boars, rats, mice, guinea pigs) have been studied using biochemical as well as light and electron microscopical techniques, in particular immunolocalizations. In these tissues, the peritubular walls represent
Michael McGregor et al.
Cell cycle (Georgetown, Tex.), 13(5), 739-748 (2013-12-24)
Centromere protein A (CENP-A) is a homolog of histone H3 that epigenetically marks the heterochromatin of chromosomes. CENP-A is a critical component of the cell cycle machinery that is necessary for proper assembly of the mitotic spindle. However, the role
Katrin Lange et al.
Cancer research, 67(13), 6163-6173 (2007-07-10)
Tenascin-C, an extracellular matrix molecule of the tumor-specific microenvironment, counteracts the tumor cell proliferation-suppressing effect of fibronectin by blocking the integrin alpha(5)beta(1)/syndecan-4 complex. This causes cell rounding and stimulates tumor cell proliferation. Tenascin-C also stimulates endothelin receptor type A (EDNRA)
Veronika Sander et al.
Nature protocols, 8(4), 800-809 (2013-03-30)
This protocol describes how to isolate primary cardiomyocytes from adult zebrafish hearts and culture them for up to 4 weeks, thereby using them as an alternative to in vivo experiments. After collagenase digestion of the ventricle, cells are exposed to
Leire Neri et al.
Oncotarget, 8(25), 40967-40981 (2017-05-13)
The identification of new targets for systemic therapy of hepatocellular carcinoma (HCC) is an urgent medical need. Recently, we showed that hNatB catalyzes the N-α-terminal acetylation of 15% of the human proteome and that this action is necessary for proper
Violaine Delorme et al.
Developmental cell, 13(5), 646-662 (2007-11-06)
Protrusion of the leading edge of migrating epithelial cells requires precise regulation of two actin filament (F-actin) networks, the lamellipodium and the lamella. Cofilin is a downstream target of Rho GTPase signaling that promotes F-actin cycling through its F-actin-nucleating, -severing
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