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Showing 1-30 of 60 results for "T8944" within Papers
Sun-Ok Kim et al.
PloS one, 8(1), e53908-e53908 (2013-01-26)
STK295900, a small synthetic molecule belonging to a class of symmetric bibenzimidazoles, exhibits antiproliferative activity against various human cancer cell lines from different origins. Examining the effect of STK295900 in HeLa cells indicates that it induces G(2) phase arrest without
Eleonora Brunello et al.
Journal of experimental & clinical cancer research : CR, 31, 103-103 (2012-12-29)
Lobular breast carcinoma usually shows poor responsiveness to chemotherapies and often lacks targeted therapies. Since FGFR1 expression has been shown to play pivotal roles in primary breast cancer tumorigenesis, we sought to analyze the status of FGFR1 gene in a
Kayleigh A Smith et al.
Genes, chromosomes & cancer, 53(2), 117-128 (2013-12-12)
Rearrangements involving the RUNX1 gene account for approximately 15% of balanced translocations in therapy-related acute myeloid leukemia (t-AML) patients and are one of the most common genetic abnormalities observed in t-AML. Drugs targeting the topoisomerase II (TOP2) enzyme are implicated
David P Boyle et al.
Biochimica et biophysica acta, 1835(2), 230-242 (2013-02-14)
The analysis of clinical breast samples using biomarkers is integral to current breast cancer management. Currently, a limited number of targeted therapies are standard of care in breast cancer treatment. However, these targeted therapies are only suitable for a subset
Andrew B Lane et al.
The Journal of cell biology, 203(3), 471-486 (2013-11-13)
DNA topoisomerase IIα (Topo IIα) is the target of an important class of anticancer drugs, but tumor cells can become resistant by reducing the association of the enzyme with chromosomes. Here we describe a critical mechanism of chromatin recruitment and
Adam C Ketron et al.
Biochemistry, 52(1), 221-227 (2012-12-21)
The polyphenol curcumin is the principal flavor and color component of the spice turmeric. Beyond its culinary uses, curcumin is believed to positively impact human health and displays antioxidant, anti-inflammatory, antibacterial, and chemopreventive properties. It also is in clinical trials
Yoshikatsu Ogawa et al.
Biochemical and biophysical research communications, 443(1), 339-343 (2013-12-11)
The naphthoquinone pigment, shikonin, is a natural product derived from Lithospermum erythrorhizon and an active component of a Chinese traditional herbal therapeutic. We identified shikonin as a candidate for shortening the circadian period using real-time reporter gene assays based on
Gary M Williams et al.
Chemico-biological interactions, 203(2), 386-390 (2013-01-24)
Fluoroquinolone (FQ) antibiotics are bacteriocidal through inhibition of the bacterial gyrase and at sufficient concentrations in vitro, they can inhibit the homologous eukaryotic topoisomerase (TOPO) II enzyme. FQ exert a variety of genotoxic effects in mammalian systems through mechanisms not
Kathryn L Gilroy et al.
PloS one, 6(2), e14693-e14693 (2011-03-02)
Type II DNA topoisomerases are essential, ubiquitous enzymes that act to relieve topological problems arising in DNA from normal cellular activity. Their mechanism of action involves the ATP-dependent transport of one DNA duplex through a transient break in a second
Belén Martínez-García et al.
Nucleic acids research, 42(3), 1821-1830 (2013-11-05)
By transporting one DNA double helix (T-segment) through a double-strand break in another (G-segment), topoisomerase II reduces fractions of DNA catenanes, knots and supercoils to below equilibrium values. How DNA segments are selected to simplify the equilibrium DNA topology is
Emily C Dykhuizen et al.
Nature, 497(7451), 624-627 (2013-05-24)
Recent exon-sequencing studies of human tumours have revealed that subunits of BAF (mammalian SWI/SNF) complexes are mutated in more than 20% of all human malignancies, but the mechanisms involved in tumour suppression are unclear. BAF chromatin-remodelling complexes are polymorphic assemblies
Rudra P Saha et al.
PLoS genetics, 9(11), e1003902-e1003902 (2013-11-19)
The E. coli chromosome is compacted by segregation into 400-500 supercoiled domains by both active and passive mechanisms, for example, transcription and DNA-protein association. We find that prophage Mu is organized as a stable domain bounded by the proximal location
K D Bromberg et al.
Biochemistry, 40(28), 8410-8418 (2001-07-11)
A common DNA religation assay for topoisomerase II takes advantage of the fact that the enzyme can rejoin cleaved nucleic acids but cannot mediate DNA scission at suboptimal temperatures (either high or low). Although temperature-induced DNA religation assays have provided
Jason T Bau et al.
Molecular pharmacology, 85(2), 198-207 (2013-11-14)
Topoisomerase II (topo II) is a ubiquitous enzyme that is essential for cell survival through its role in regulating DNA topology and chromatid separation. Topo II can be poisoned by common chemotherapeutics (such as doxorubicin and etoposide), leading to the
Boryana Petrova et al.
Molecular and cellular biology, 33(5), 984-998 (2012-12-25)
Chromosomes undergo extensive conformational rearrangements in preparation for their segregation during cell divisions. Insights into the molecular mechanisms behind this still poorly understood condensation process require the development of new approaches to quantitatively assess chromosome formation in vivo. In this
José M Calderón-Montaño et al.
Pharmacological reports : PR, 64(6), 1515-1525 (2013-02-15)
DNA-damaging compounds (e.g., alkylating agents, cytotoxic antibiotics and DNA topoisomerase poisons) are the most widely used anticancer drugs. The inability of tumor cells to properly repair some types of DNA damage may explain why specific DNA-damaging drugs can selectively kill
Gang Chen et al.
Journal of cancer research and therapeutics, 9 Suppl 2, S98-100 (2013-10-30)
The aim of this study was to evaluate whether there was an association between pathology type and ERCC1, BRCA1, RRM1, TUBB3, STMN1, TOP2A and epidermal growth factor receptor (EGFR) messenger ribonucleic acid (mRNA) expression level in Chinese patients with non-small
Z Kolar et al.
Neoplasma, 61(1), 9-16 (2013-11-08)
Fusion of TMPRSS2 with ERG in prostate cells is determined by double-strand DNA breaks induced by androgen signaling and transcription stress. The enzyme topoisomerase 2β (TOP2B) mediating DNA processing, plays an important role in DNA cleavage. The aim of this
Yeonee Seol et al.
The Journal of biological chemistry, 288(19), 13695-13703 (2013-03-20)
Human topoisomerase IIα unlinks catenated chromosomes and preferentially relaxes positive supercoils. Supercoil chirality, twist density, and tension determine topoisomerase IIα relaxation rate and processivity. Strand passage rate is determined by the efficiency of transfer segment capture that is modulated by
A Táncsics et al.
International journal of systematic and evolutionary microbiology, 64(Pt 1), 298-301 (2014-01-11)
The results of 16S rRNA, gyrB and catA gene sequence comparisons and reasserted DNA-DNA hybridization unambiguously proved that Rhodococcus jialingiae Wang et al. 2010 and Rhodococcus qingshengii Xu et al. 2007 represent a single species. On the basis of priority
S Lokeswara Balakrishna et al.
Archives of biochemistry and biophysics, 532(2), 91-102 (2013-02-13)
HIV-1 reverse transcription (RTn) involves synthesis of double strand DNA (dsDNA) from viral genomic RNA. Topoisomerase II (Topo II) alpha and beta maintains topological reorganization of dsDNA regions and catalytic inhibition of these isoforms repressed viral replicative cycle. Present study
PTTG1 expression and it's rapidly evolving role in the progression and development of systemic malignancies.
Journal of experimental therapeutics & oncology, 10(2), 163-164 (2013-01-29)
M Vanni et al.
Poultry science, 93(4), 856-863 (2014-04-08)
Escherichia coli are a common inhabitant of the gastrointestinal tract of mammals and birds; nevertheless, they may be associated with a variety of severe and invasive infections. Whereas fluoroquinolones (FQ) have been banned in the United States for use in
Tim Wang et al.
Science (New York, N.Y.), 343(6166), 80-84 (2013-12-18)
The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system for genome editing has greatly expanded the toolbox for mammalian genetics, enabling the rapid generation of isogenic cell lines and mice with modified alleles. Here, we describe a pooled, loss-of-function
Hye Sung Won et al.
Tumori, 100(1), 80-86 (2014-03-29)
The aims of this study were to investigate the correlation between topoisomerase II alpha (TOP2A), microtubule-associated protein-tau (MAP-tau) and other prognostic factors in breast cancer and to evaluate the predictive value of TOP2A and MAP-tau in breast cancer patients who
Adam B Shapiro
Biochemical pharmacology, 85(9), 1269-1277 (2013-02-19)
A novel, high-throughput-compatible assay for the ATP-dependent supercoiled DNA relaxing activity of human topoisomerase IIα (hTopoIIα) is described. The principle of detection is the preferential binding of the oligodeoxyribonucleotide BODIPY-TMR-5'-TTCTTCTTCT-3' to relaxed double-stranded plasmid containing the triplex forming sequence (TTC)9
Anthracyclines and heart failure.
Douglas B Sawyer
The New England journal of medicine, 368(12), 1154-1156 (2013-03-22)
Matt J Griffin et al.
Diseases of aquatic organisms, 108(1), 23-35 (2014-02-05)
A new Edwardsiella taxon was recently described from fishes of Europe and Asia. Phenotypically similar to E. tarda, extensive genetic and phenotypic characterization determined this new strain does not belong to any established Edwardsiella taxa, leading to the adoption of
Rajeev Bala et al.
The American journal of surgical pathology, 37(5), 659-668 (2013-04-05)
Although the incidence of human papillomavirus (HPV)-associated anal neoplasia is increasing, interobserver and intraobserver reproducibility in the grading of biopsy specimens from this area remains unacceptably low. Attempts to produce a more reproducible grading scheme have led to the use
DNA topoisomerases.
M Gellert
Annual review of biochemistry, 50, 879-910 (1981-01-01)
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