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Showing 1-30 of 98 results for "T9003" within Papers
Yonghui Hou et al.
Chinese medicine, 17(1), 85-85 (2022-07-13)
Bu-Shen-Huo-Xue (BSHX) decoction has been used in the postoperative rehabilitation of patients with spinal cord injury in China. In the present study, we aim to reveal the bioactive compounds in BSHX decoction and comprehensively explore the effects of BSHX decoction
Hermann Bultmann et al.
Antimicrobial agents and chemotherapy, 54(10), 4275-4289 (2010-07-21)
The linear cationic amphiphilic EB peptide, derived from the FGF4 signal sequence, was previously shown to be virucidal and to block herpes simplex type I (HSV-1) entry (H. Bultmann, J. S. Busse, and C. R. Brandt, J. Virol. 75:2634-2645, 2001).
M Lichtenstein et al.
Traffic (Copenhagen, Denmark), 2(4), 261-267 (2001-04-04)
mRNA export is mediated by RNA-binding proteins which shuttle between the nucleus and cytoplasm. Using an in vitro unidirectional export assay, we observe that the shuttling mRNA-binding protein, hnRNP A1, is exported only extremely slowly unless incubations are supplemented with
Maria C Heinz et al.
STAR protocols, 1(3), 100126-100126 (2020-12-31)
Patient-derived organoids maintain functional and phenotypic characteristics of the original tissue such as cell-type diversity. Here, we provide protocols on how to label intestinal (cancer) stem cells by integrating the stem cell ASCL2 reporter (STAR) into human and mouse genomes
Trypsin and chymotrypsin inhibitors from soybeans.
Y Birk
Methods in enzymology, 45, 700-707 (1976-01-01)
Eunice Andrè et al.
The Journal of clinical investigation, 118(7), 2574-2582 (2008-06-24)
Cigarette smoke (CS) inhalation causes an early inflammatory response in rodent airways by stimulating capsaicin-sensitive sensory neurons that express transient receptor potential cation channel, subfamily V, member 1 (TRPV1) through an unknown mechanism that does not involve TRPV1. We hypothesized
Philip M Day et al.
The Plant cell, 31(8), 1845-1855 (2019-06-21)
Chloroplasts evolved from a cyanobacterial endosymbiont that resided within a eukaryotic cell. Due to their prokaryotic heritage, chloroplast outer membranes contain transmembrane β-barrel proteins. While most chloroplast proteins use N-terminal transit peptides to enter the chloroplasts through the translocons at
J Grauvogel et al.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 10(5), 603-612 (2010-10-29)
The mechanism of alcoholic pancreatitis is still unknown. It is of special interest why only about 5% of all alcoholics develop an episode of pancreatitis. We evaluated the role of long-term alcohol intake in the pathogenesis of alcoholic pancreatitis in
P Pierre
Methods in molecular medicine, 64, 413-422 (2001-01-01)
The initiation and propagation of the immune responses is dependent on the ability of antigen-presenting cells (APC) to convert proteins into peptides, to load them intracellularly onto major histocompatibility complex (MHC), and then to deliver the peptide-MHC complexes to the
Margit Rosner et al.
Nature protocols, 8(3), 602-626 (2013-03-02)
This protocol describes a method for nucleocytoplasmic protein tracking during normal cell cycle progression using unmanipulated, asynchronous cells. In contrast with prevalent traditional methods, our approach does not require time-consuming, perturbing cell synchronization or separation. To this end, we chose
Risheng Ye et al.
The American journal of pathology, 189(4), 813-825 (2019-01-18)
Syntrophins are a family of proteins forming membrane-anchored scaffolds and serving as adaptors for various transmembrane and intracellular signaling molecules. To understand the physiological roles of β1 syntrophin, one of the least characterized members, we generated mouse models to eliminate
Xiaolin Qu et al.
Frontiers in genetics, 12, 628841-628841 (2021-03-06)
Messager RNA (mRNA) can be modified in a variety of ways, among which the modification of N6-methyladenosine (m6A) is one of the most common ones. Recent studies have found that the m6A modification in mRNA could functionally regulate the splicing
R J Thurston et al.
Biology of reproduction, 48(2), 393-402 (1993-02-01)
Protease and basic amidase activity was found in the seminal plasma of the domestic turkey. Amidase activity, measured through use of N-alpha-benzoyl-DL-arginine-p-nitroanilide-HCL (BAPNA), was 23-28 times greater for turkey than for guinea fowl or chicken. Within the reproductive tract, seminal
Leiling Pan et al.
Cancers, 13(19) (2021-10-14)
The Notch signaling pathway is an evolutionary conserved signal transduction cascade present in almost all tissues and is required for embryonic and postnatal development, as well as for stem cell maintenance, but it is also implicated in tumorigenesis including pancreatic
Sara Fukushima et al.
iScience, 24(7), 102778-102778 (2021-07-20)
Emerging evidence has shown that amino acids act as metabolic regulatory signals. Here, we showed that glucose-6-phosphatase (G6Pase) mRNA levels in cultured hepatocyte models were downregulated in an amino-acid-depleted medium. Inversely, stimulation with amino acids increased G6Pase mRNA levels, demonstrating
Patrick L Leslie et al.
Nature communications, 10(1), 4192-4192 (2019-09-15)
Lymph node (LN) metastases correspond with a worse prognosis in nearly all cancers, yet the occurrence of cancer spreading from LNs remains controversial. Additionally, the mechanisms explaining how cancers survive and exit LNs are largely unknown. Here, we show that
Vilmos Tóth et al.
Cellular and molecular life sciences : CMLS, 79(9), 471-471 (2022-08-07)
In synapses that show signs of local apoptosis and mitochondrial stress and undergo neuro-immunological synapse pruning, an increase in the levels of the presynaptic protein, neuronal-specific septin-3 can be observed. Septin-3 is a member of the septin GTPase family with
Yasmine Kamen et al.
STAR protocols, 2(2), 100439-100439 (2021-04-27)
Single-cell electrophysiological recordings combined with dye loading and immunohistochemistry provide unparalleled single-cell resolution of cell physiology, morphology, location, and protein expression. When correlated with bulk RNA sequencing, these data can define cell identity and function. Here, we describe a protocol
Domenico Azarnia Tehran et al.
Bio-protocol, 8(13), e2918-e2918 (2018-07-05)
Cerebellar Granule Neurons (CGN) from post-natal rodents have been widely used as a model to study neuronal development, physiology and pathology. CGN cultured in vitro maintain the same features displayed in vivo by mature cerebellar granule cells, including the development
Shingo Kikuchi et al.
The Plant cell, 21(6), 1781-1797 (2009-06-18)
Chloroplast protein import is mediated by two hetero-oligomeric protein complexes, the Tic and Toc translocons, which are located in the inner and outer envelope membranes. At the inner membrane, many Tic components have been identified and characterized, but it remains
Christian Lévêque et al.
Scientific reports, 5, 17953-17953 (2015-12-10)
The enzymatic activity of the pathogenic botulinum neurotoxins type A and E (BoNT/A and E) leads to potentially lethal paralytic symptoms in humans and their prompt detection is of crucial importance. A chip assay based on Surface Plasmon Resonance monitoring
Rubhana Raqib et al.
Human vaccines & immunotherapeutics, 15(6), 1326-1337 (2019-02-23)
Shigella sonnei live vaccine candidate, WRSS1, which was previously evaluated in US, Israeli and Thai volunteers, was administered orally to Bangladeshi adults and children to assess its safety, clinical tolerability and immunogenicity. In a randomized, placebo-controlled, dose-escalation, age-descending study, 39
Direna Alonso-Curbelo et al.
Nature, 590(7847), 642-648 (2021-02-05)
Tissue damage increases the risk of cancer through poorly understood mechanisms1. In mouse models of pancreatic cancer, pancreatitis associated with tissue injury collaborates with activating mutations in the Kras oncogene to markedly accelerate the formation of early neoplastic lesions and
Ruiling Liu et al.
Nature communications, 13(1), 3545-3545 (2022-06-22)
Pancreatic β cell dysfunction contributes to the pathogenesis of type 2 diabetes. MiR-21 has been shown to be induced in the islets of glucose intolerant patients and type 2 diabetic mice. However, the role of miR-21 in the regulation of
Wenhong Li et al.
Journal of cell science, 134(8) (2021-03-17)
The mechanisms underlying the cellular response to extracellular matrices (ECMs) that consist of multiple adhesive ligands are still poorly understood. Here, we address this topic by monitoring specific cellular responses to two different extracellular adhesion molecules - the main integrin
Sandip M Swain et al.
JCI insight, 7(8) (2022-04-23)
Pancreatic fibrosis is a complication of chronic pancreatitis and is a prominent feature of pancreatic cancer. Pancreatic fibrosis is commonly observed in patients with prolonged pancreatic duct obstruction, which elevates intrapancreatic pressure. We show here that increased pancreatic duct pressure
Ying Wang et al.
Cell, 171(2), 331-345 (2017-09-26)
Clearance of apoptotic cells (ACs) by phagocytes (efferocytosis) prevents post-apoptotic necrosis and dampens inflammation. Defective efferocytosis drives important diseases, including atherosclerosis. For efficient efferocytosis, phagocytes must be able to internalize multiple ACs. We show here that uptake of multiple ACs
Rong Wang et al.
PloS one, 12(2), e0171926-e0171926 (2017-02-17)
The susceptibility of a dietary protein to proteolytic degradation by digestive enzymes, such as gastric pepsin, provides information on the likelihood of systemic exposure to a structurally intact and biologically active macromolecule, thus informing on the safety of proteins for
Osamu Ikehara et al.
The journal of physiological sciences : JPS, 64(2), 119-128 (2014-01-15)
Proteases play a diverse role in health and disease. An excessive concentration of proteases has been found in the feces of patients with inflammatory bowel disease or irritable bowel syndrome and been implicated in the pathogenesis of such disorders. This
Vladimir Pliska et al.
Biochemical pharmacology, 91(1), 119-127 (2014-07-11)
Entropy (ΔS), enthalpy (ΔH) and heat capacity (ΔCp) changes attending the oxytocin interaction with its two binding sites on myometrial cell membranes in sheep were derived from the temperature dependence of Kd values. The high affinity oxytocin site (Kd on
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