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Showing 1-30 of 46 results for "T9126" within Papers
Quantitative Mapping of Triacylglycerol Chain Length and Saturation Using Broadband CARS Microscopy.
Alexandra Paul et al.
Biophysical journal, 116(12), 2346-2355 (2019-06-04)
Lipid droplets (LDs), present in many cell types, are highly dynamic organelles that store neutral lipids, primarily triacylglycerols (TAGs). With the discovery of new LD functions (e.g., in immune response, protein clearage, and occurrence with disease), new methods to study
Xunjun Xiao et al.
Biochimica et biophysica acta, 1831(9), 1435-1441 (2013-06-19)
Efficient dietary fat digestion is essential for newborns who consume more dietary fat per body weight than at any other time of life. In many mammalian newborns, pancreatic lipase related protein 2 (PLRP2) is the predominant duodenal lipase. Pigs may
Shen-Zhi Wang et al.
Food chemistry, 299, 125164-125164 (2019-07-19)
Control of lipid digestibility by various food components has received great attention in recent decades. However, there is limited literature on investigating the synergistic effect of exogenous emulsifiers and endogenous sodium cholate (SC) on lipid digestion in a simulated physiological
Masahiro Okajima et al.
Drug discoveries & therapeutics, 7(2), 90-94 (2013-05-30)
Surfactant-free emulsions by adding jojoba oil, squalane, olive oil, or glyceryl trioctanoate (medium chain fatty acid triglycerides, MCT) to electrolytic-reduction ion water containing lithium magnesium sodium silicate (GE-100) were prepared, and their physiochemical properties (thixotropy, zeta potential, and mean particle
Angela Bourbon Freie et al.
The Journal of biological chemistry, 281(12), 7793-7800 (2006-01-25)
In a previous study, we demonstrated that the beta5'-loop in the C-terminal domain of human pancreatic triglyceride lipase (hPTL) makes a major contribution in the function of hPTL (Chahinian et al. (2002) Biochemistry 41, 13725-13735). In the present study, we
Madhumita Das et al.
Genes & development, 25(6), 634-645 (2011-03-17)
The cJun NH(2)-terminal kinase (JNK) signal transduction pathway has been implicated in the growth of carcinogen-induced hepatocellular carcinoma. However, the mechanism that accounts for JNK-regulated tumor growth is unclear. Here we demonstrate that compound deficiency of the two ubiquitously expressed
M K McKenna et al.
Cancer biology & therapy, 16(7), 1088-1098 (2015-05-29)
Withaferin A (WA), a withanolide from the plant, Ashwagandha (Withania somnifera) used in Ayurvedic medicine, has been found to be valuable in the treatment of several medical ailments. WA has been found to have anticancer activity against various solid tumors
K Mircheva et al.
Colloids and surfaces. B, Biointerfaces, 86(1), 71-80 (2011-04-19)
The purpose of this article was to describe the kinetics of the enzymatic action of one or more enzymes on mixture of substrates organized in 2D structures in order to mimic some situations existing in biological or industrial systems. Hydrolysis
Ben Achrai et al.
The journal of physical chemistry. B, 115(5), 825-835 (2010-12-25)
In the present work, we report on the solubilization of gabapentin (GBP) into lyotropic hexagonal mesophases composed of monoolein, tricaprylin, and water. It was demonstrated that the hexagonal structure remained intact up to 2 wt % gabapentin, whereas the lamellar
Pedro Reis et al.
Langmuir : the ACS journal of surfaces and colloids, 24(14), 7400-7407 (2008-06-13)
Tensiometry (the pendant drop technique), interfacial shear rheology, and ellipsometry have been used to study the effect of polar lipids that are generated during fat digestion on the behavior of lipases at the oil-water interface. Both Sn-1,3 regiospecific and nonregiospecific
Tanya S McDonald et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(1), 153-160 (2013-10-31)
Medium chain triglycerides (MCTs) are used to treat neurologic disorders with metabolic impairments, including childhood epilepsy and early Alzheimer's disease. However, the metabolic effects of MCTs in the brain are still unclear. Here, we studied the effects of feeding even
Antía Lestido-Cardama et al.
Foods (Basel, Switzerland), 9(8) (2020-08-06)
Food packaging has received special attention from the food safety standpoint since it could be a potential source of contamination through the migration of chemical substances from the packaging material into food. The assessment of the exposure through the diet
Dima Libster et al.
International journal of pharmaceutics, 367(1-2), 115-126 (2008-11-04)
The present work investigates the detailed molecular structure of the H(II) mesophase of GMO/tricaprylin/phosphatidylcholine/water system in the presence of hydrophobic model peptide Cyclosporin A (CSA) via ATR-FTIR analysis. The conformation of the peptide in the hexagonal mesophase, as well as
Tz Ivanova et al.
Colloids and surfaces. B, Biointerfaces, 63(1), 91-100 (2008-01-08)
The hydrolysis catalyzed by Humicola lanuginosa lipase (HLL) of pure tricaprylin (TC) or stearate of polyethylene glycol 1500 (PEG-St) as well as their mixtures spread as monomolecular films were studied. The catalytic transformation of the two substrates TC or PEG-St
S P McDermott et al.
Oncogene, 26(10), 1407-1416 (2006-09-06)
We previously showed that mice with a null mutation in syndecan-1 (Sdc1; CD138) were resistant to Wnt1-induced mammary tumor initiation. The absence of Sdc1 inhibited the increase in the mammary stem cell fraction that is characteristic of preneoplasia in this
Marganit Cohen-Avrahami et al.
Journal of controlled release : official journal of the Controlled Release Society, 159(3), 419-428 (2012-02-07)
Penetratin, a cell penetrating peptide is embedded within a reversed hexagonal (H(II)) mesophase for improved transdermal delivery of sodium diclofenac (Na-DFC). The H(II) mesophase serves as the solubilization reservoir and gel matrix whereas penetratin is the transdermal penetration enhancer for
Idit Amar-Yuli et al.
The journal of physical chemistry. B, 112(33), 10171-10180 (2008-07-31)
The solubilization of four bioactive molecules with different polarities, in three reverse hexagonal (HII) systems has been investigated. The three HII systems were a typical reverse hexagonal composed of glycerol monooleate (GMO)/tricaprylin/water and two fluid hexagonal systems containing either 2.75
Ying Li et al.
PloS one, 16(2), e0247236-e0247236 (2021-02-20)
Berberine is a promising botanical pesticide against fungal plant pathogens. However, whether berberine inhibits the invasion of fungal pathogen across plant surface remains unclear. Here we demonstrated that the enzyme activities of purified cutinase from fungal pathogen Colletotrichum capsici were
Sagar S Rane et al.
Molecular pharmaceutics, 5(6), 1023-1036 (2009-05-13)
Triglycerides and related fatty acid esters constitute a large percentage of the lipid excipients employed in the development of lipid-based drug formulations. Computer simulations can provide useful information on the structural, dynamic, and thermodynamic properties of these systems and may
Mark A Tetrick et al.
Comparative medicine, 60(6), 486-490 (2011-01-26)
Premature newborn infants are born with limited stores of glycogen and fat. Energy, such as medium-chain triglycerides (MCT), which can spare the use of body protein as metabolic energy, may be beneficial. This study compares MCT containing C8, C9, or
Eduardo Mateos-Díaz et al.
Methods in molecular biology (Clifton, N.J.), 861, 89-100 (2012-03-20)
High-throughput screening (HTS) methods for lipases and esterases are generally performed by using synthetic chromogenic substrates (e.g., p-nitrophenyl, resorufin, and umbelliferyl esters) which may be misleading since they are not their natural substrates (e.g., partially or insoluble triglycerides). In previous
Alexandre Courchesne-Loyer et al.
Nutrition (Burbank, Los Angeles County, Calif.), 29(4), 635-640 (2013-01-01)
In humans consuming a normal diet, we investigated 1) the capacity of a medium-chain triacylglycerol (MCT) supplement to stimulate and sustain ketonemia, 2) ¹³C-β-hydroxybutyrate and ¹³C-trioctanoate metabolism, and 3) the theoretical contribution of the degree of ketonemia achieved to brain
Jeong Ho Jeon et al.
Applied microbiology and biotechnology, 81(5), 865-874 (2008-09-06)
To search for new cold-active lipases, a metagenomic library was constructed using cold-sea sediment samples at Edison Seamount and was screened for lipolytic activities by plating on a tricaprylin medium. Subsequently, a fosmid clone was selected, and the whole sequence
Ting Xiong et al.
Colloids and surfaces. B, Biointerfaces, 171, 1-9 (2018-07-14)
This study adopted the method of quantitative proteomics to analyze the adsorbed proteins in oil-in-water emulsions stabilized by pea protein isolate (PPI). Adsorbed proteins were precipitated by an optimized precipitation method and precipitates were labeled and subjected to a reversed-phase
Lysozyme entrapped within reverse hexagonal mesophases: physical properties and structural behavior.
Tehila Mishraki et al.
Colloids and surfaces. B, Biointerfaces, 75(1), 47-56 (2009-09-15)
A model protein (lysozyme) was incorporated into monoolein-based reverse hexagonal (H(II)) mesophase and its structure effects were characterized by small angle X-ray scattering, ATR-FTIR spectroscopy, and rheological measurements. Modifications in molecular organization of the H(II) mesophases as well as the
Yasmine Jamoussi et al.
Colloids and surfaces. B, Biointerfaces, 197, 111432-111432 (2020-11-10)
Oil-in-water nanoemulsions are used in numerous biomedical applications as delivery systems. The droplet size in the nanometer range and their composition were extensively developed for carrying and enhancing the absorption of lipophilic drugs and lipids of interest. In the present
Nissim Garti et al.
Colloids and surfaces. B, Biointerfaces, 94, 36-43 (2012-02-22)
The present work investigates a system composed of a ternary reversed hexagonal mesophase (H(II)) loaded with a lipase for modulating drug delivery capabilities of the system. Thermomyces lanuginosa lipase was solubilized into H(II) mesophase for the benefits of continuing lipolysis
Dong-zhi Hou et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 42(4), 429-433 (2007-07-18)
Novel solid lipid nanoparticle (SLN) system is prepared with Compritol ATO 888 and tricaprylic glyceride. DSC, XRD, SAXS and NMR are employed to study the novel carrier property and microstructure. When the peak melting point decreased from 70.8 degrees C
Sagar S Rane et al.
Pharmaceutical research, 25(5), 1158-1174 (2007-12-21)
This paper aims to elucidate quantitative relationships between small molecule solubility/water-uptake in triglyceride/monoglyceride lipid formulations, the chemical structure of the solute, and the solvent composition. Solubility and water uptake in tricaprylin/1-monocaprylin and tricaprylin/1-monocaprin mixtures in the "microemulsion" region at 37
Yu-Kuo Chen et al.
The Journal of nutritional biochemistry, 26(5), 484-504 (2015-03-15)
5-Demethylnobiletin is a hydroxylated polymethoxyflavone found in citrus plants that shows antiproliferative activities in several cancer cell lines. In this study, we investigated the effects and underlying molecular mechanisms of 5-demethylnobiletin on inhibition of cell growth, apoptosis, cell cycle and
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