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Showing 1-30 of 54 results for "T9283" within Papers
Myofibril Degeneration Caused by Tropomodulin Overexpression Leads to Dilated Cardiomyopathy in Juvenile Mice
Sussman MA
The Journal of Clinical Investigation, 101, 51-61 (1998)
Ina Strate et al.
Development (Cambridge, England), 142(10), 1767-1776 (2015-05-15)
Glypicans are heparan sulphate proteoglycans (HSPGs) attached to the cell membrane by a glycosylphosphatidylinositol (GPI) anchor, and interact with various extracellular growth factors and receptors. The Drosophila division abnormal delayed (dally) was the first glypican loss-of-function mutant described that displays
Haruhiro Toko et al.
The Journal of biological chemistry, 289(9), 5348-5356 (2014-01-01)
Autologous c-kit(+) cardiac progenitor cells (CPCs) are currently used in the clinic to treat heart disease. CPC-based regeneration may be further augmented by better understanding molecular mechanisms of endogenous cardiac repair and enhancement of pro-survival signaling pathways that antagonize senescence
Jung-Kang Jin et al.
Circulation research, 120(5), 862-875 (2016-12-10)
Endoplasmic reticulum (ER) stress causes the accumulation of misfolded proteins in the ER, activating the transcription factor, ATF6 (activating transcription factor 6 alpha), which induces ER stress response genes. Myocardial ischemia induces the ER stress response; however, neither the function
Lieven Thorrez et al.
Frontiers in physiology, 9, 1076-1076 (2018-09-05)
Adult skeletal muscle progenitor cells can be embedded in an extracellular matrix (ECM) and tissue-engineered to form bio-artificial muscles (BAMs), composed of aligned post-mitotic myofibers. The ECM proteins which have been used most commonly are collagen type I and fibrin.
Natalie Gude et al.
Circulation research, 99(4), 381-388 (2006-07-15)
Activation of Akt is associated with enhanced cell cycling and cellular proliferation in nonmyocytes, but this effect of nuclear Akt accumulation has not been explored in the context of the myocardium. Cardiac-specific expression of nuclear-targeted Akt (Akt/nuc) in transgenics prolongs
Yuki Otsuki et al.
Biomedical research (Tokyo, Japan), 36(1), 11-19 (2015-03-10)
Adipose stem cells (ASCs) are a source of regenerative cells available for autologous transplantation to hearts. We compared protective actions of ASC sheets on rat myocardial infarction (MI) in comparison with those of skeletal myoblast cell sheets. Their effects on
Karl-Henrik Grinnemo et al.
Annals of medicine, 38(2), 144-153 (2006-04-04)
As the capability of human mesenchymal stem cells (hMSC) to engraft, differentiate and improve myocardial function cannot be studied in humans, exploration was performed in a xenomodel. The rats were divided into three groups depending on the type of rats
Ajit Magadum et al.
Cell research, 27(8), 1002-1019 (2017-06-18)
Zebrafish can efficiently regenerate their heart through cardiomyocyte proliferation. In contrast, mammalian cardiomyocytes stop proliferating shortly after birth, limiting the regenerative capacity of the postnatal mammalian heart. Therefore, if the endogenous potential of postnatal cardiomyocyte proliferation could be enhanced, it
Polina Gross et al.
Scientific reports, 6, 23431-23431 (2016-03-24)
Determination of fundamental mechanisms of disease often hinges on histopathology visualization and quantitative image analysis. Currently, the analysis of multi-channel fluorescence tissue images is primarily achieved by manual measurements of tissue cellular content and sub-cellular compartments. Since the current manual
Indroneal Banerjee et al.
American journal of physiology. Heart and circulatory physiology, 296(5), H1694-H1704 (2009-02-24)
Interleukin-6 (IL-6) is a pleiotropic cytokine responsible for many different processes including the regulation of cell growth, apoptosis, differentiation, and survival in various cell types and organs, including the heart. Recent studies have indicated that IL-6 is a critical component
K H Grinnemo et al.
The Journal of thoracic and cardiovascular surgery, 127(5), 1293-1300 (2004-04-30)
It is thought that adult human mesenchymal stem cells do not induce immunoreactivity even to xenografts. We wanted to study whether adult human mesenchymal stem cells survive and engraft in experimentally induced ischemic rat myocardium. Bone marrow-derived adult human mesenchymal
Rachel C Kelley et al.
Journal of molecular and cellular cardiology, 139, 238-249 (2020-02-09)
Inspiratory dysfunction occurs in patients with heart failure with reduced ejection fraction (HFrEF) in a manner that depends on disease severity and by mechanisms that are not fully understood. In the current study, we tested whether HFrEF effects on diaphragm
Erik A Blackwood et al.
Nature communications, 10(1), 187-187 (2019-01-16)
Pharmacologic activation of stress-responsive signaling pathways provides a promising approach for ameliorating imbalances in proteostasis associated with diverse diseases. However, this approach has not been employed in vivo. Here we show, using a mouse model of myocardial ischemia/reperfusion, that selective
Rolf Schreckenberg et al.
Antioxidants & redox signaling, 23(15), 1220-1232 (2015-05-16)
Research into right ventricular (RV) physiology and identification of pathomechanisms underlying RV failure have been neglected for many years, because function of the RV is often considered less important for overall hemodynamics and maintenance of blood circulation. In view of
Ana Elisa Teófilo Saturi de Carvalho et al.
Scientific reports, 7(1), 15434-15434 (2017-11-15)
Cardiac energy metabolism must cope with early postnatal changes in tissue oxygen tensions, hemodynamics, and cell proliferation to sustain development. Here, we tested the hypothesis that proliferating neonatal cardiomyocytes are dependent on high oxidative energy metabolism. We show that energy-related
Sailay Siddiqi et al.
Circulation research, 103(1), 89-97 (2008-06-04)
Stem cell-specific proteins and regulatory pathways that determine self-renewal and differentiation have become of fundamental importance in understanding regenerative and reparative processes in the myocardium. One such regulatory protein, named nucleostemin, has been studied in the context of stem cells
Rashid Nassar et al.
American journal of physiology. Heart and circulatory physiology, 288(3), H1147-H1156 (2004-10-30)
Four isoforms of cardiac troponin T (cTnT), a protein essential for calcium-dependent myocardial force development, are expressed in the human; they differ in charge and length. Their expression is regulated developmentally and is affected by disease states. Human cTnT (hcTnT)
Tropomyosin-1 acts as a potential tumor suppressor in human oral squamous cell carcinoma
Pan H
PLoS ONE, 12, e0168900-e0168900 (2017)
Yu-Huan Shih et al.
Development (Cambridge, England), 143(24), 4713-4722 (2016-11-12)
Titin-truncating variants (TTNtvs) are the major cause of dilated cardiomyopathy (DCM); however, allelic heterogeneity (TTNtvs in different exons) results in variable phenotypes, and remains a major hurdle for disease diagnosis and therapy. Here, we generated a panel of ttn mutants
Shuying Xie et al.
Journal of molecular cell biology, 12(1), 42-54 (2019-03-30)
There are intense interests in discovering proregenerative medicine leads that can promote cardiac differentiation and regeneration, as well as repair damaged heart tissues. We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart
Natalie A Gude et al.
Circulation research, 102(9), 1025-1035 (2008-03-29)
The Notch network regulates multiple cellular processes, including cell fate determination, development, differentiation, proliferation, apoptosis, and regeneration. These processes are regulated via Notch-mediated activity that involves hepatocyte growth factor (HGF)/c-Met receptor and phosphatidylinositol 3-kinase/Akt signaling cascades. The impact of HGF
W Rozek et al.
Polish journal of veterinary sciences, 16(4), 663-669 (2013-01-01)
Changes in the level of cellular proteins in cells inoculated with equine influenza virus H7N7 and H3N8 were studied with microarray technique. H3N8 induced pro-apoptotic proteins while H7N7 induced both pro- as well as anti-apoptotic factors. The higher level of
Margherita Burattini et al.
Macromolecular bioscience, 23(7), e2300019-e2300019 (2023-04-15)
For tissue engineering of skeletal muscles, there is a need for biomaterials which do not only allow cell attachment, proliferation, and differentiation, but also support the physiological conditions of the tissue. Next to the chemical nature and structure of the
Courtney A Powell et al.
American journal of physiology. Cell physiology, 283(5), C1557-C1565 (2002-10-10)
Human bioartificial muscles (HBAMs) are tissue engineered by suspending muscle cells in collagen/MATRIGEL, casting in a silicone mold containing end attachment sites, and allowing the cells to differentiate for 8 to 16 days. The resulting HBAMs are representative of skeletal
Jianli Shi et al.
Developmental biology, 395(2), 287-298 (2014-09-16)
Wnt signaling and ciliogenesis are core features of embryonic development in a range of metazoans. Chibby (Cby), a basal-body associated protein, regulates β-catenin-mediated Wnt signaling in the mouse but not Drosophila. Here we present an analysis of Cby's embryonic expression
Markus Wallner et al.
Circulation research, 119(7), 865-879 (2016-07-28)
Catecholamines increase cardiac contractility, but exposure to high concentrations or prolonged exposures can cause cardiac injury. A recent study demonstrated that a single subcutaneous injection of isoproterenol (ISO; 200 mg/kg) in mice causes acute myocyte death (8%-10%) with complete cardiac
Dacha Gholobova et al.
Tissue engineering. Part A, 21(19-20), 2548-2558 (2015-07-16)
The size of in vitro engineered skeletal muscle tissue is limited due to the lack of a vascular network in vitro. In this article, we report tissue-engineered skeletal muscle consisting of human aligned myofibers with interspersed endothelial networks. We extend
D Gholobova et al.
Scientific reports, 8(1), 12206-12206 (2018-08-17)
The development of laboratory-grown tissues, referred to as organoids, bio-artificial tissue or tissue-engineered constructs, is clearly expanding. We describe for the first time how engineered human muscles can be applied as a pre- or non-clinical model for intramuscular drug injection
Galina Schevzov et al.
Bioarchitecture, 1(4), 135-164 (2011-11-10)
Tropomyosins are rod-like dimers which form head-to-tail polymers along the length of actin filaments and regulate the access of actin binding proteins to the filaments.1 The diversity of tropomyosin isoforms, over 40 in mammals, and their role in an increasing
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