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Showing 1-30 of 1545 results for "U0631" within Papers
Dara P O'Halloran et al.
Infection and immunity, 83(4), 1598-1609 (2015-02-04)
The immunoglobulin binding protein A (SpA) of Staphylococcus aureus is synthesized as a precursor with a C-terminal sorting signal. The sortase A enzyme mediates covalent attachment to peptidoglycan so that SpA is displayed on the surface of the bacterium. Protein
Milaim Pepaj et al.
Scandinavian journal of clinical and laboratory investigation, 74(4), 358-365 (2014-04-04)
Transmembrane protein 27 (Tmem27), which is expressed in pancreatic β-cells, plays an important role in insulin secretion and pancreatic β-cell proliferation. Analysis of the INS-1 cell proteome using stable isotope labeling by amino acids in cell culture (SILAC) in combination
Michaela Herrmann et al.
European biophysics journal : EBJ, 44(7), 503-512 (2015-05-29)
Bilayer mechanical properties are not only of crucial importance to the mechanism of action of mechanosensation in lipid membranes but also affect preparative laboratory tasks such as membrane-protein refolding. We report this for coupled refolding and bilayer insertion of outer membrane
Kameswaran Ravichandran et al.
American journal of physiology. Renal physiology, 308(4), F349-F357 (2014-12-30)
Renal cyst enlargement is associated with the activation of both the circulating and intrarenal renin-angiotensin systems. Angiotensinogen (AGT) is the substrate for renin. The aim of the present study was to determine the effect of AGT inhibition on renal cyst
Larry D Cowgill
The Veterinary clinics of North America. Small animal practice, 41(1), 193-225 (2011-01-22)
Hemodialysis improves survival for animals with acute kidney injury beyond what would be expected with conventional management of the same animals. Clinical evidence and experience in human patients suggest a role for earlier intervention with renal replacement to avoid the
Tzung-Yi Lin et al.
PloS one, 9(7), e101980-e101980 (2014-07-08)
The liver plays a vital role in metabolism, detoxification, digestion, and the maintenance of homeostasis. During development, the vertebrate embryonic liver undergoes a series of morphogenic processes known as hepatogenesis. Hepatogenesis can be separated into three interrelated processes: endoderm specification
Frazer I Heinis et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 309(4), R368-R377 (2015-05-29)
The hearts of mammalian hibernators maintain contractile function in the face of severe environmental stresses during winter heterothermy. To enable survival in torpor, hibernators regulate the expression of numerous genes involved in excitation-contraction coupling, metabolism, and stress response pathways. Understanding
Chiung-Yao Fang et al.
Virology, 483, 1-12 (2015-05-11)
During polyomavirus infection, the viral DNA adopts histones from host cells and forms minichromosomes as an important part of the viral life cycle. However, the detailed mechanisms of this histone incorporation remain unclear. Here, we profiled the histone posttranslational modifications
Wen Zhang et al.
Methods (San Diego, Calif.), 81, 50-55 (2015-02-28)
Clinical tissue samples provide valuable information for understanding human diseases. One major type of clinical tissue sample that is amenable to various kinds of analysis is fresh frozen and optimal cutting temperature (OCT)-embedded primary patient tissue. Recent advances in mass
Hao Feng et al.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 272(10), 2629-2642 (2014-08-02)
Increased application of silver nanoparticles (AgNPs) has raised concerns on their potential adverse effects on human health. However, the precise toxicological mechanisms are not known in detail. The current study hypothesized that AgNPs induced glycosaminoglycan accumulation in the basement membrane
Samuel Gelis et al.
Microbiology (Reading, England), 161(6), 1260-1270 (2015-03-18)
Saccharomyces cerevisiae mutants lacking both isoforms of the main plasma membrane potassium transporter display impaired potassium transport and defective growth at limiting concentrations of the cation. Moreover, they are hyperpolarized and have a lower intracellular pH than wild-type. In order
Mun Chiang Chan et al.
PloS one, 10(7), e0132004-e0132004 (2015-07-07)
As part of the cellular adaptation to limiting oxygen availability in animals, the expression of a large set of genes is activated by the upregulation of the hypoxia-inducible transcription factors (HIFs). Therapeutic activation of the natural human hypoxic response can
Cell-based therapies for experimental chronic kidney disease: a systematic review and meta-analysis.
Diana A Papazova et al.
Disease models & mechanisms, 8(3), 281-293 (2015-01-31)
Cell-based therapy is a promising strategy for treating chronic kidney disease (CKD) and is currently the focus of preclinical studies. We performed a systematic review and meta-analysis to evaluate the efficacy of cell-based therapy in preclinical (animal) studies of CKD
Zan Dai et al.
Nanoscale, 7(28), 11991-11999 (2015-06-26)
Hierarchical Bi(3.64)Mo(0.36)O(6.55)/Bi2MoO6 isotype heterostructures were successfully prepared via a one-pot hydrothermal route by using Bi2O3 porous nanospheres as a sacrificial template. By tuning the reaction time, the formation process of the Bi(3.64)Mo(0.36)O(6.55)/Bi2MoO6 heterostructure involving Mo etching, phase transition and anisotropic
Yang Hong et al.
Journal of proteomics, 124, 25-38 (2015-04-22)
The aim of this study was to search for immunogenic schistosomula proteins in the hope of identifying novel intervention targets. Schistosomula proteins were analyzed by immunoproteomic which the probes were sera derived from BALB/c mice (susceptible hosts) and Microtus fortis
Keumhan Noh et al.
Archives of pharmacal research, 38(1), 68-72 (2014-03-19)
Aceclofenac is one of the most popular analgesic and anti-inflammatory drugs used for the relief of pain, rheumatoid arthritis, and osteoarthritis. To date, no intravenous preparation of aceclofenac has been developed because of its poor water solubility. In this study
Leticia Monin et al.
The Journal of clinical investigation, 125(12), 4699-4713 (2015-11-17)
Parasitic helminth worms, such as Schistosoma mansoni, are endemic in regions with a high prevalence of tuberculosis (TB) among the population. Human studies suggest that helminth coinfections contribute to increased TB susceptibility and increased rates of TB reactivation. Prevailing models
Peng Gao et al.
PloS one, 10(7), e0133913-e0133913 (2015-07-29)
Bivalve shell is a biomineralized tissue with various layers/microstructures and excellent mechanical properties. Shell matrix proteins (SMPs) pervade and envelop the mineral crystals and play essential roles in biomineralization. Despite that Mytilus is an economically important bivalve, only few proteomic
Luciana S Oliveira et al.
PloS one, 9(6), e98913-e98913 (2014-06-10)
C57BL/6 mice macrophages innately produce higher levels of NO than BALB/c cells when stimulated with LPS. Here, we investigated the molecular events that account for this intrinsic differential production of NO. We found that the lower production of NO in
Michael Neely et al.
Journal of clinical pharmacology, 55(7), 798-808 (2015-02-17)
Few studies have characterized longitudinal female plasma and genital antiretroviral pharmacokinetics and pharmacodynamics. Among 20 regimen-naive HIV-infected adult women initiating atazanavir-based therapy (n = 9) or efavirenz-based therapy (n = 11), we measured blood CD4+ T lymphocytes, and paired plasma and genital HIV RNA
Stephanie Brown et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(11), 3205-3210 (2015-02-13)
The monoterpene indole alkaloids are a large group of plant-derived specialized metabolites, many of which have valuable pharmaceutical or biological activity. There are ∼3,000 monoterpene indole alkaloids produced by thousands of plant species in numerous families. The diverse chemical structures
Lise Bankir et al.
Kidney international, 81(12), 1179-1198 (2012-03-30)
The mechanism by which urine is concentrated in the mammalian kidney remains incompletely understood. Urea is the dominant urinary osmole in most mammals and may be concentrated a 100-fold above its plasma level in humans and even more in rodents.
M Ahmed Mesaik et al.
Journal of agricultural and food chemistry, 63(1), 177-184 (2014-12-17)
Recent evidence suggests an important role for natural honey in modulating immune response. To identify active components responsible, this study investigated the immunomodulatory properties of glycoproteins and glycopeptides fractionated from Ziziphus honey. Honey proteins/peptides were fractionated by size exclusion chromatography
Kehua Wang et al.
PloS one, 9(7), e102914-e102914 (2014-07-23)
Heat stress is a primary factor causing summer bentgrass decline. Changes in gene expression at the transcriptional and/or translational level are thought to be a fundamental mechanism in plant response to environmental stresses. Heat stress redirects protein synthesis in higher
S Fukahori et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 72(2), 238-244 (2015-07-16)
The combination of nitrogen recovery and pharmaceutical removal processes for livestock urine treatment were investigated to suppress the discharge of pollutants and recover nitrogen as resources. We combined methylene urea synthesis from urea and adsorption and photocatalytic decomposition of sulfonamide
Jihye Kim et al.
Analytical and bioanalytical chemistry, 407(29), 8745-8752 (2015-09-26)
Single-drop microextraction (SDME) was in-line coupled with capillary electrophoresis-mass spectrometry to provide sample cleanup and enrichment simultaneously. Since there is no outlet vial in a conventional capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS) configuration, it is not easy to hang a single
Lars Malmström et al.
Journal of proteomics, 129, 98-107 (2015-09-19)
The increasing number of bacterial genomes in combination with reproducible quantitative proteome measurements provides new opportunities to explore how genetic differences modulate proteome composition and virulence. It is challenging to combine genome and proteome data as the underlying genome influences
Erik L de Graaf et al.
Journal of proteome research, 14(7), 2906-2914 (2015-05-27)
We report a straightforward strategy to comprehensively monitor signal transduction pathway dynamics in mammalian systems. Combining targeted quantitative proteomics with highly selective phosphopeptide enrichment, we monitor, with great sensitivity, phosphorylation dynamics of the PI3K-mTOR and MAPK signaling networks. Our approach
Lidia Jiménez-Garcia et al.
European journal of immunology, 45(1), 273-286 (2014-10-21)
Alternative activation of macrophages plays an important role in a range of physiological and pathological processes. This alternative phenotype, also known as M2 macrophages, is induced by type 2 cytokines such as IL-4. The binding of IL-4 to its receptor
Romain Simon et al.
Journal of chromatography. A, 1354, 75-84 (2014-06-17)
Liquid chromatography (LC) coupled with tandem mass spectrometry (MS-MS) in selected reaction monitoring mode (SRM) has become a widely used technique for the quantification of protein biomarkers in plasma and has already proven to give similar results compared to the
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