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Showing 1-30 of 280 results for "U1128" within Papers
Makoto Ayaori et al.
Journal of the American Heart Association, 2(1), e003277-e003277 (2013-03-26)
Endothelial dysfunction is an independent predictor for cardiovascular events in patients with type 2 diabetes (T2DM). Glucagon like peptide-1 (GLP-1) reportedly exerts vasodilatory actions, and inhibitors of dipeptidyl peptidase-4 (DPP-4), an enzyme-degrading GLP-1, are widely used to treat T2DM. We
Kristof Hormann et al.
Journal of chromatography. A, 1365, 94-105 (2014-09-25)
The morphology of silica monoliths determines their mass transport properties. While eddy dispersion can be related to the size and structural heterogeneity of the macropores, longitudinal diffusion and trans-skeleton mass transfer resistance are influenced by the physical appearance of the
Martin Gilar et al.
Journal of chromatography. A, 1381, 110-117 (2015-01-22)
Sample introduction in microfluidic liquid chromatography often generates wide zones rather than peaks, especially when a large sample volume (relative to column volume) is injected. Formation of wide injection zones can be further amplified when the sample is dissolved in
Steve Swinnen et al.
Eukaryotic cell, 14(9), 884-897 (2015-06-28)
Very high ethanol tolerance is a distinctive trait of the yeast Saccharomyces cerevisiae with notable ecological and industrial importance. Although many genes have been shown to be required for moderate ethanol tolerance (i.e., 6 to 12%) in laboratory strains, little
Lei Du-Cuny et al.
Bioorganic & medicinal chemistry, 17(19), 6983-6992 (2009-09-08)
Computational modeling continues to play an important role in novel therapeutics discovery and development. In this study, we have investigated the use of in silico approaches to develop inhibitors of the pleckstrin homology (PH) domain of AKT (protein kinase B).
Shannen L Cravens et al.
Nucleic acids research, 43(8), 4087-4097 (2015-04-08)
Intracellular space is at a premium due to the high concentrations of biomolecules and is expected to have a fundamental effect on how large macromolecules move in the cell. Here, we report that crowded solutions promote intramolecular DNA translocation by
Pin-Chao Liao et al.
STAR protocols, 1(3), 100160-100160 (2020-12-31)
The redox state of mitochondria is one indicator of the functional state of the organelles. Mitochondria are also the primary endogenous source of reactive oxygen species (ROS). Therefore, the redox state of the organelles also reflects their function in ROS
Shijia Liu et al.
Analytical and bioanalytical chemistry, 407(30), 8989-8997 (2015-10-03)
A novel imidazolium-embedded N,N-dimethylaminopropyl-functionalized silica-based stationary phase (Sil-ImCl) was prepared and further used for hydrophilic interaction/reversed-phase mixed-mode chromatography. The Sil-ImCl stationary phase was respectively characterized by Fourier transform infrared spectrometry, thermogravimetric analysis, and element analysis. A variety of hydrophilic or
Pavel Jandera et al.
Journal of chromatography. A, 1410, 76-89 (2015-08-05)
We studied possibilities of prediction of the gradient elution data for alkylbenzenes, flavones and phenolic acids on two short octadecyl silica gel monolithic columns, namely a Chromolith Flash C18, 25×4.6mm, and a "new generation" Chromolith High Resolution C18, 50×4.6mm, in
Hyunah Kim et al.
PloS one, 10(7), e0129914-e0129914 (2015-07-03)
O-mannosylation, the addition of mannose to serine and threonine residues of secretory proteins, is a highly conserved post-translational modification found in organisms ranging from bacteria to humans. Here, we report the functional and molecular characterization of the HpPMT4 gene encoding
Anna Ostapowicz et al.
Przeglad lekarski, 69(9), 694-697 (2013-02-14)
5-fluorouracil (5-FU) and its prodrug capecitabine are one of the most commonly used chemotherapeutic drugs. DPD-deficient cancer patients may be at risk of severe and sometimes lethal toxicity after the administration of 5-FU. In 39-61% of the cases severe toxicity
Michael Wolferstätter et al.
Journal of virology, 88(24), 14396-14411 (2014-10-10)
Double-stranded RNA (dsRNA) is an important molecular pattern associated with viral infection and is detected by various extra- and intracellular recognition molecules. Poxviruses have evolved to avoid producing dsRNA early in infection but generate significant amounts of dsRNA late in
Pang-Hung Hsu et al.
PloS one, 10(8), e0135174-e0135174 (2015-08-14)
The budding yeast Saccharomyces cerevisiae has recently been described as an emerging opportunistic fungal pathogen. Fungal cell wall mannoproteins have been demonstrated to be involved in adhesion to inert surfaces and might be engaged in virulence. In this study, we
Jianzhen Shen et al.
Biochemical genetics, 53(9-10), 268-279 (2015-08-25)
Our purpose was to investigate the effect of 3-deazaneplanocin A (DZNep) on human T-cell acute lymphoid leukemia (T-ALL) cells, and to explore the underlying molecular mechanisms. The human T-ALL cell line Molt4 was treated with DZNep, and cell proliferation was
Ekaterina Kuznetsova et al.
The Journal of biological chemistry, 290(30), 18678-18698 (2015-06-14)
The haloacid dehalogenase (HAD)-like enzymes comprise a large superfamily of phosphohydrolases present in all organisms. The Saccharomyces cerevisiae genome encodes at least 19 soluble HADs, including 10 uncharacterized proteins. Here, we biochemically characterized 13 yeast phosphatases from the HAD superfamily
Kateřina Svobodová et al.
Molecular biology reports, 42(8), 1257-1264 (2015-03-10)
Eukaryotic translation elongation factor 1 alpha (EEF1A) plays a key role in protein synthesis. In higher vertebrates EEF1A occurs in two isoforms, EEF1A1 and EEF1A2, encoded by distinct genes. The purpose of this study was to compare the two porcine
Robert W Maul et al.
European journal of immunology, 44(7), 1913-1916 (2014-06-13)
During the immune response, B cells undergo a programed mutagenic cascade to promote increased affinity and expanded antibody function. The two processes, somatic hypermutation (SHM) and class switch recombination (CSR), are initiated by the protein activation-induced deaminase (AID), which converts
Alexandre Grand-Guillaume Perrenoud et al.
Journal of chromatography. A, 1360, 275-287 (2014-08-19)
Superficially porous particles (SPP), or core shell particles, which consist of a non-porous silica core surrounded by a thin shell of porous silica, have gained popularity as a solid support for chromatography over the last decade. In the present study
Yan Ma et al.
Journal of chromatography. A, 1383, 47-57 (2015-02-05)
Prototype small-size (1.0mm I.D., 5cm long) columns for reversed-phase HPLC were evaluated in relation to instrument requirements. The performance of three types of columns, monolithic silica and particulate silica (2μm, totally porous and 2.6μm, core-shell particles) was studied in the
Antoine M Snijders et al.
Oncotarget, 5(12), 4011-4025 (2014-07-06)
The concept that a breast cancer patient's menstrual stage at the time of tumor surgery influences risk of metastases remains controversial. The scarcity of comprehensive molecular studies of menstrual stage-dependent fluctuations in the breast provides little insight in this observation.
Alexander C Roy et al.
Bioorganic & medicinal chemistry letters, 20(1), 141-144 (2009-12-17)
CTP synthase (CTPS) catalyzes the conversion of UTP to CTP and is a recognized target for the development of anticancer, antiviral, and antiprotozoal agents. Xanthine and related compounds inhibit CTPS activity (IC(50)=0.16-0.58mM). The presence of an 8-oxo function (i.e., uric
Fumiaki Sugiura et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 40(12), 1584-1586 (2014-01-08)
Complementary DNA( cDNA) microarray technology coupled with laser microdissection has been used to identify human leukocyte antigen (HLA)-A24-restricted epitope peptides as potential targets for cancer vaccination in colorectal cancer patients. These antigenic peptides were derived from 2 different cancer-testis antigens
Bogumil J Karas et al.
Nature communications, 6, 6925-6925 (2015-04-22)
Eukaryotic microalgae hold great promise for the bioproduction of fuels and higher value chemicals. However, compared with model genetic organisms such as Escherichia coli and Saccharomyces cerevisiae, characterization of the complex biology and biochemistry of algae and strain improvement has
Victor K Langsi et al.
Journal of chromatography. A, 1402, 17-26 (2015-06-02)
Nanometer control over the porous shell thickness of sub-2-μm-shell particles is investigated. Three seeded growth mesoporous thin shell particles for HPLC were prepared, with 0.05μm (or 50nm) porous shell layers: particle sizes 1.5μm (solid core diameters 1.4μm), 1.7μm (solid core
R Chaubey et al.
International journal of laboratory hematology, 37(2), 265-271 (2014-08-16)
The inactivation of suppressor of cytokine signaling SOCS-1, a negative regulator of cytokine pathways, by hypermethylation was shown in hematological malignancies including Myelsplastic Syndromes. So far, its prognostic relevance in myelodysplastic syndromes (MDS) patients has not been understood. Methylation status
Torkild Visnes et al.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 364(1517), 563-568 (2008-11-15)
Uracil in DNA may result from incorporation of dUMP during replication and from spontaneous or enzymatic deamination of cytosine, resulting in U:A pairs or U:G mismatches, respectively. Uracil generated by activation-induced cytosine deaminase (AID) in B cells is a normal
William B White et al.
The New England journal of medicine, 369(14), 1327-1335 (2013-09-03)
To assess potentially elevated cardiovascular risk related to new antihyperglycemic drugs in patients with type 2 diabetes, regulatory agencies require a comprehensive evaluation of the cardiovascular safety profile of new antidiabetic therapies. We assessed cardiovascular outcomes with alogliptin, a new
Benjamin L Golomb et al.
Journal of bacteriology, 197(2), 371-381 (2014-11-12)
Lactic acid bacteria have been isolated from living, harvested, and fermented plant materials; however, the adaptations these bacteria possess for growth on plant tissues are largely unknown. In this study, we investigated plant habitat-specific traits of Lactococcus lactis during growth
Joong Won Lee et al.
Inhalation toxicology, 27(13), 724-730 (2015-11-04)
Growing evidence indicates that prenatal exposure to maternal smoking is a risk factor for the development of asthma in children. However, the effects of prenatal environmental tobacco smoke (ETS) exposure on the genome and lung immune cells are unclear. This
Amy I Yu et al.
Cell reports, 31(1), 107471-107471 (2020-04-09)
There is increasing evidence that gut microbiome perturbations, also known as dysbiosis, can influence colorectal cancer development. To understand the mechanisms by which the gut microbiome modulates cancer susceptibility, we examine two wild-type mouse colonies with distinct gut microbial communities
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