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Showing 1-30 of 108 results for "U4375" within Papers
Tetsuya Hirata et al.
Biochimica et biophysica acta. General subjects, 1864(12), 129726-129726 (2020-09-06)
N-Glycosylation is crucial for protein folding, trafficking, and functions. N-Glycans have a different number of N-acetylglucosamine (GlcNAc) branches in a protein-selective manner, and the β1,6-linked GlcNAc branch on specific proteins produced by N-acetylglucosaminyltransferase-V (GnT-V or MGAT5) promotes cancer malignancy. However
Amit Lather et al.
BMC chemistry, 14(1), 41-41 (2020-06-25)
Preservatives have to be added in food, pharmaceuticals and cosmetics products to maintain their shelf life. However, the existing chemical based preservatives have been associated with severe side effects that compel the researchers to find better safe preservatives based on
Katsuhiro Sawasato et al.
Scientific reports, 9(1), 1372-1372 (2019-02-06)
MPIase is a glycolipid that is involved in membrane protein integration. Despite evaluation of its functions in vitro, the lack of information on MPIase biosynthesis hampered verification of its involvement in vivo. In this study, we found that depletion of
Leif R Neitzel et al.
Mechanisms of development, 156, 20-31 (2019-03-25)
In a screen for human kinases that regulate Xenopus laevis embryogenesis, we identified Nagk and other components of the UDP-GlcNAc glycosylation salvage pathway as regulators of anteroposterior patterning and Wnt signaling. We find that the salvage pathway does not affect
Hiroyuki Kajiura et al.
Biochemical and biophysical research communications, 529(2), 404-410 (2020-07-25)
N-Acetylglucosaminyltransferase II (GNTII), which catalyzes the transfer of N-acetylglucosamine to N-glycans, plays an essential role in the biosynthesis of branched and complex-type N-glycans. Some characteristics of the GNTIIs from various species have been identified, but not all features have been
Solmaz Sobhanifar et al.
PLoS pathogens, 12(12), e1006067-e1006067 (2016-12-16)
In recent years, there has been a growing interest in teichoic acids as targets for antibiotic drug design against major clinical pathogens such as Staphylococcus aureus, reflecting the disquieting increase in antibiotic resistance and the historical success of bacterial cell
Linhong Zhao et al.
International journal of molecular sciences, 21(1) (2019-12-29)
Both OGT1 (O-linked β-N-acetylglucosamine (O-GlcNAc) transferase isoform 1) and NSL3 (nonspecific lethal protein 3) are crucial components of the MOF (males absent on the first)/NSL histone acetyltransferase complex. We previously described how global histone H4 acetylation levels were modulated by
Mingzuo Jiang et al.
Theranostics, 9(18), 5359-5373 (2019-08-15)
Metastasis is the primary cause of death in patients with advanced cancer. Recently, a high-fat diet was shown to specifically promote the metastatic potential of specific cancer cells in a CD36-dependent manner. However, the molecular basis of the fatty acid
Angelika Timofeeva et al.
International journal of molecular sciences, 21(24) (2020-12-17)
As part of the optimization of assisted reproductive technology programs, the aim of the study was to identify key small noncoding RNA (sncRNA) molecules that participate in maternal-to-zygotic transition and determine development potential and competence to form a healthy fetus.
Mitsutaka Ogawa et al.
Biochemical and biophysical research communications, 526(1), 184-190 (2020-03-24)
The Notch signaling pathway is highly conserved and essential in animal development and tissue homeostasis. Regulation of Notch signaling is a crucial process for human health. Ligands initiate a signal cascade by binding to Notch receptors expressed on the neighboring
Zhengliang L Wu et al.
Cell chemical biology, 25(11), 1428-1435 (2018-08-14)
O-GlcNAcylation is a reversible serine/threonine glycosylation for regulating protein activity and availability inside cells. In a given protein, O-GlcNAcylated and unoccupied O-linked β-N-acetylglucosamine (O-GlcNAc) sites are referred to as closed and open sites, respectively. The balance between open and closed
Friedemann Flügge et al.
ChemistryOpen, 8(6), 760-769 (2019-07-11)
Human blood group A and B glycosyltransferases (GTA, GTB) are retaining glycosyltransferases, requiring a catalytic mechanism that conserves the anomeric configuration of the hexopyranose moiety of the donor substrate (UDP-GalNAc, UDP-Gal). Previous studies have shown that GTA and GTB cycle
Minela Haskovic et al.
Journal of inherited metabolic disease, 43(3), 392-408 (2019-12-07)
Since the first description of galactosemia in 1908 and despite decades of research, the pathophysiology is complex and not yet fully elucidated. Galactosemia is an inborn error of carbohydrate metabolism caused by deficient activity of any of the galactose metabolising
Yubo Liu et al.
Scientific reports, 7(1), 12334-12334 (2017-09-28)
O-GlcNAc transferase (OGT) plays an important role in regulating numerous cellular processes through reversible post-translational modification of nuclear and cytoplasmic proteins. However, the function of O-GlcNAcylation is still not well understood. Cell permeable OGT inhibitors are needed to manipulate O-GlcNAcylation
Juliana Falero-Perez et al.
PloS one, 15(4), e0231752-e0231752 (2020-04-25)
Astrocytes (AC) are the most abundant cells in the central nervous system. In the retina, astrocytes play important roles in the development and integrity of the retinal neurovasculature. Astrocytes dysfunction contributes to pathogenesis of a variety of neurovascular diseases including
J A Hanover
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 15(11), 1865-1876 (2001-09-05)
The addition of O-linked N-acetylglucosamine (O-GlcNAc) to target proteins may serve as a signaling modification analogous to protein phosphorylation. Like phosphorylation, O-GlcNAc is a dynamic modification occurring in the nucleus and cytoplasm. Various analytical methods have been developed to detect
Florence Uchenna Eze et al.
Bioorganic chemistry, 92, 103265-103265 (2019-09-17)
Ten new derivatives of benzenesulphonamide bearing carboxamide functionality were synthesized and investigated for their in vitro antimicrobial, antioxidant and in vivo anti-inflammatory activities. Compound 9d inhibited carrageenan induced rat-paw oedema at 93.81, 88.79 and 86.09% at 1 h, 2 h and 3 h
Muhamad Ansar et al.
International journal of molecular sciences, 21(19) (2020-10-11)
The incidence and mortality rates of colorectal cancer (CRC) have been high in recent years. Prevention and early detection are crucial for decreasing the death rate. Therefore, this study aims to characterize the alteration patterns of mothers against decapentaplegic homolog
Dustin T King et al.
The Journal of biological chemistry, 292(3), 979-993 (2016-12-03)
In Escherichia coli, the peptidoglycan cell wall is synthesized by bifunctional penicillin-binding proteins such as PBP1b that have both transpeptidase and transglycosylase activities. The PBP1b transpeptidase domain is a major target of β-lactams, and therefore it is important to attain
Federico Cividini et al.
The Journal of biological chemistry, 291(51), 26515-26528 (2016-11-07)
mtDNA damage in cardiac myocytes resulting from increased oxidative stress is emerging as an important factor in the pathogenesis of diabetic cardiomyopathy. A prevalent lesion that occurs in mtDNA damage is the formation of 8-hydroxy-2'-deoxyguanosine (8-OHdG), which can cause mutations
Gertrud Grilz-Seger et al.
BMC genomics, 20(1), 174-174 (2019-03-07)
The sample ascertainment bias due to complex population structures remains a major challenge in genome-wide investigations of complex traits. In this study we derived the high-resolution population structure and levels of autozygosity of 377 Lipizzan horses originating from five different
Shrestha Sinha-Ray et al.
Frontiers in microbiology, 8, 1770-1770 (2017-09-30)
Many bacterial pathogens promote biofilms that confer resistance against stressful survival conditions. Likewise
Hiroshi Manya et al.
The Journal of biological chemistry, 291(47), 24618-24627 (2016-10-14)
A defect in O-mannosyl glycan is the cause of α-dystroglycanopathy, a group of congenital muscular dystrophies caused by aberrant α-dystroglycan (α-DG) glycosylation. Recently, the entire structure of O-mannosyl glycan, [3GlcAβ1-3Xylα1]
LXRalpha Regulates Hepatic ChREBPalpha Activity and Lipogenesis upon Glucose, but Not Fructose Feeding in Mice
Fan Q, et al.
Nutrients, 9(7), 678-678 (2017)
Daniel Castillo et al.
Applied and environmental microbiology, 81(3), 1157-1167 (2014-12-07)
Flavobacterium psychrophilum is an important fish pathogen in salmonid aquaculture worldwide. Due to increased antibiotic resistance, pathogen control using bacteriophages has been explored as a possible alternative treatment. However, the effective use of bacteriophages in pathogen control requires overcoming the
Qian-Hui Sun et al.
EBioMedicine, 53, 102693-102693 (2020-03-03)
Treatment of Crohn's disease (CD) remains to be a challenge due to limited insights for its pathogenesis. We aimed to determine the role of O-Linked β-N-acetylglucosamine (O-GlcNAc) in the development of CD and evaluate therapeutic effects of O-GlcNAc inhibitors on
Heidi E Schwartz-Zimmermann et al.
Archives of toxicology, 91(12), 3857-3872 (2017-06-24)
The Fusarium mycotoxin deoxynivalenol (DON) is a frequent contaminant of cereal-based food and feed. Mammals metabolize DON by conjugation to glucuronic acid (GlcAc), the extent and regioselectivity of which is species-dependent. So far, only DON-3-glucuronide (DON-3-GlcAc) and DON-15-GlcAc have been
Thomas Dupas et al.
Acta physiologica (Oxford, England), 231(3), e13566-e13566 (2020-10-07)
Metabolic sources switch from carbohydrates in utero, to fatty acids after birth and then a mix once adults. O-GlcNAcylation (O-GlcNAc) is a post-translational modification considered as a nutrient sensor. The purpose of this work was to assess changes in protein
Sadie K Dierschke et al.
Investigative ophthalmology & visual science, 61(2), 24-24 (2020-02-19)
O-GlcNAcylation of cellular proteins contributes to the pathophysiology of diabetes and evidence supports a role for augmented O-GlcNAcylation in diabetic retinopathy. The aim of this study was to investigate the impact of the renin-angiotensin system on retinal protein O-GlcNAcylation. Mice
Zheng Han et al.
Toxins, 5(12), 2671-2685 (2013-12-20)
Ochratoxin A (OTA), one of the most toxic mycotoxins, can contaminate a wide range of food and feedstuff. To date, the data on its conjugates via glucuronidation request clarification and consolidation. In the present study, the combined approaches of ultra
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