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Showing 1-30 of 116 results for "U5379" within Papers
Aya Murakami et al.
Neuropathology : official journal of the Japanese Society of Neuropathology, 41(5), 357-365 (2021-07-27)
We describe an autopsy case of neuronal intermediate filament inclusion disease (NIFID), a subtype of frontotemporal lobar degeneration (FTLD) with the appearance of fused-in-sarcoma (FUS) inclusions (FTLD-FUS). A 57-year-old man developed dysarthria and dysphagia. One year and five months later, he
Katrin Juenemann et al.
Frontiers in molecular neuroscience, 8, 1-1 (2015-02-13)
Protein conformation diseases, including polyglutamine (polyQ) diseases, result from the accumulation and aggregation of misfolded proteins. Huntington's disease (HD) is one of nine diseases caused by an expanded polyQ repeat within the affected protein and is hallmarked by intracellular inclusion
R Brandimarti et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(25), 13973-13978 (1998-02-12)
The US9 gene of herpes simplex virus 1 encodes a virion tegument protein with a predicted Mr of 10,000. Earlier studies have shown that the gene is not essential for viral replication in cells in culture. We report that (i)
M Buchwald et al.
Oncogene, 32(41), 4913-4920 (2012-12-05)
Activated Cdc42-associated kinase 1 (ACK1) is a nonreceptor tyrosine kinase linked to cellular transformation. The aberrant regulation of ACK1 promotes tumor progression and metastasis. Therefore, ACK1 is regarded as a valid target in cancer therapy. Seven in absentia homolog (SIAH)
Sylvie Urbé et al.
Molecular biology of the cell, 23(6), 1095-1103 (2012-02-03)
Ubiquitination is a reversible modification that influences a broad range of physiological processes. There are approximately 90 deubiquitinases (DUBs) encoded in the human genome, of which 79 are predicted to have catalytic activity. We tagged 66 DUBs with green fluorescent
Xing Huang et al.
The EMBO journal, 32(16), 2204-2216 (2013-06-12)
The primary role of autophagy is adaption to starvation. However, increasing evidence suggests that autophagy inhibition also plays an important role in tumorigenesis. Upregulation of X-linked inhibitor of apoptosis (XIAP) has been associated to a variety of human cancers, yet
Sankaranarayanan Kannan et al.
Molecular cancer therapeutics, 18(9), 1615-1627 (2019-06-23)
In B-cell acute lymphoblastic leukemia (B-ALL), activation of Notch signaling leads to cell-cycle arrest and apoptosis. We aimed to harness knowledge acquired by understanding a mechanism of Notch-induced cell death to elucidate a therapeutically viable target in B-ALL. To this
Junyan Shi et al.
Autophagy, 9(10), 1591-1603 (2013-08-31)
The adaptor protein, sequestosome 1 (SQSTM1)/p62, plays an essential role in mediating selective autophagy. It serves as an autophagy receptor targeting ubiquitinated proteins to autophagosomes for degradation. In addition, it functions as a scaffold protein to regulate signaling pathways. Here
Sandra Franco-Iborra et al.
Autophagy, 17(3), 672-689 (2020-02-26)
The precise degradation of dysfunctional mitochondria by mitophagy is essential for maintaining neuronal homeostasis. HTT (huntingtin) can interact with numerous other proteins and thereby perform multiple biological functions within the cell. In this study, we investigated the role of HTT
Lihui Wang et al.
Scientific reports, 5, 17818-17818 (2015-12-08)
In eukaryotic cells, the ubiquitin-proteasome system as a key regulator of protein quality control is an excellent drug target. We therefore aimed to analyze the 26S proteasome complex in the malaria parasite Plasmodium falciparum, which still threatens almost half of
Yoshiko Iizuka-Hishikawa et al.
The Journal of biological chemistry, 292(29), 12065-12076 (2017-06-05)
Docosahexaenoic acid (DHA) is one of the essential ω-3 polyunsaturated fatty acids with a wide range of physiological roles important for human health. For example, DHA renders cell membranes more flexible and is therefore important for cellular function, but information
Chiu-Yueh Hung et al.
Cellular and molecular life sciences : CMLS, 79(11), 553-553 (2022-10-18)
Pathophysiology associated with Huntington's disease (HD) has been studied extensively in various cell and animal models since the 1993 discovery of the mutant huntingtin (mHtt) with abnormally expanded polyglutamine (polyQ) tracts as the causative factor. However, the sequence of early
Jiangwei Zhang et al.
Nature cell biology, 17(10), 1259-1269 (2015-09-08)
Peroxisomes are highly metabolic, autonomously replicating organelles that generate reactive oxygen species (ROS) as a by-product of fatty acid β-oxidation. Consequently, cells must maintain peroxisome homeostasis, or risk pathologies associated with too few peroxisomes, such as peroxisome biogenesis disorders, or
Wieke Freudenburg et al.
PloS one, 8(2), e52408-e52408 (2013-02-06)
Autoimmune destruction of insulin producing pancreatic β-cells is the hallmark of type I diabetes. One of the key molecules implicated in the disease onset is the immunoproteasome, a protease with multiple proteolytic sites that collaborates with the constitutive 19S and
Gina N Calco et al.
The Journal of biological chemistry, 289(11), 7307-7319 (2014-01-16)
Ret is the receptor tyrosine kinase for the glial cell line-derived neurotrophic factor (GDNF) family of neuronal growth factors. Upon activation by GDNF, Ret is rapidly polyubiquitinated and degraded. This degradation process is isoform-selective, with the longer Ret51 isoform exhibiting
The ubiquitin-proteasome pathway: on protein death and cell life.
A Ciechanover
The EMBO journal, 17(24), 7151-7160 (1998-12-19)
Takashi Ayaki et al.
Acta neuropathologica communications, 2, 172-172 (2014-12-11)
Mutations in the valosin-containing protein (VCP) gene were first found to cause inclusion- body myopathy with early-onset Paget disease and frontotemporal dementia (IBMPFD). Mutations in the VCP gene were later reported to occur in familial amyotrophic lateral sclerosis (ALS). But
Janakiram Reddy Vangala et al.
The Journal of biological chemistry, 289(18), 12612-12622 (2014-03-15)
The ubiquitin-proteasome system facilitates the degradation of ubiquitin-tagged proteins and performs a regulatory role in cells. Elevated proteasome activity and subunit expression are found in several cancers. However, the inherent molecular mechanisms responsible for increased proteasome function in cancers remain
Toshiaki Tanaka et al.
Journal of cell science, 126(Pt 13), 2785-2797 (2013-04-23)
The transcription factor p53 plays a crucial role in coordinating the cellular response to various stresses. Therefore, p53 protein levels and activity need to be kept under tight control. We report here that diacylglycerol kinase ζ (DGKζ) binds to p53
Noah Machuki Onchieku et al.
Pathogens (Basel, Switzerland), 10(11) (2021-11-28)
Reduced sensitivity of the human malaria parasite, Plasmodium falciparum, to Artemisinin and its derivatives (ARTs) threatens the global efforts towards eliminating malaria. ARTs have been shown to cause ubiquitous cellular and genetic insults, which results in the activation of the
Michel Engeln et al.
Annals of neurology, 74(1), 140-144 (2013-03-16)
Dopamine dysregulation syndrome shares some core behavioral features with psychostimulant addiction, suggesting that dopamine replacement therapy can acquire psychostimulantlike properties in some patients with Parkinson disease (PD). We here report strong experimental evidence supporting this hypothesis in an α-synuclein rat
Sylvia Müller et al.
Oncotarget, 5(10), 3184-3196 (2014-05-17)
The Janus tyrosine kinases JAK1-3 and tyrosine kinase-2 (TYK2) are frequently hyperactivated in tumors. In lung cancers JAK1 and JAK2 induce oncogenic signaling through STAT3. A putative role of TYK2 in these tumors has not been reported. Here, we show
Mariola Słowińska et al.
International journal of molecular sciences, 22(19) (2021-10-14)
In birds, the zona pellucida (ZP) matrix that surrounds the ovulated oocyte-called the inner perivitelline layer-is involved in sperm-zona interaction and successful fertilization. To identify the important genes and proteins connected with the final step of egg development, next-generation sequencing
Xiao-Li Lin et al.
PLoS genetics, 12(4), e1006016-e1006016 (2016-04-30)
COP1 (CONSTITUTIVE PHOTOMORPHOGENIC 1), a ubiquitin E3 ligase, is a central negative regulator of photomorphogenesis. However, how COP1 activity is regulated by post-translational modifications remains largely unknown. Here we show that SUMO (small ubiquitin-like modifier) modification enhances COP1 activity. Loss-of-function
Maria K Mateyak et al.
Cell cycle (Georgetown, Tex.), 5(23), 2796-2804 (2006-12-19)
The evolutionarily conserved PIF1 DNA helicase family is important for the maintenance of genome stability in the yeast, Saccharomyces cerevisiae. There are two PIF1 family helicases in S. cerevisiae, Pif1p and Rrm3p that both possess 5'-->3' DNA helicase activity but
Mathieu Bourdenx et al.
Scientific reports, 7, 45831-45831 (2017-04-05)
Neurodegenerative diseases are characterized by the degeneration of specific brain areas associated with accumulation of disease-related protein in extra- or intra-cellular deposits. Their preclinical investigations are mostly based on genetically-engineered animals. Despite their interest, these models are often based on
Weiqian Mi et al.
Brain : a journal of neurology, 128(Pt 2), 405-416 (2005-01-13)
Axonal dystrophy is the hallmark of axon pathology in many neurodegenerative disorders of the CNS, including Alzheimer's disease, Parkinson's disease and stroke. Axons can also form larger swellings, or spheroids, as in multiple sclerosis and traumatic brain injury. Some spheroids
M Nakamura et al.
Neuropathology and applied neurobiology, 37(3), 307-314 (2010-09-08)
Smad ubiquitination regulatory factor-2 (Smurf2) is an E3 ligase that belongs to the HECT domain ubiquitin ligase family. Smurf2 can interact with Smad proteins and promote their ubiquitin-dependent degradation, thereby controlling the cellular levels of these signalling mediators. Phosphorylated Smad2/3
Gabriela Zárraga-Granados et al.
PloS one, 15(3), e0222072-e0222072 (2020-03-27)
NR4A is a nuclear receptor protein family whose members act as sensors of cellular environment and regulate multiple processes such as metabolism, proliferation, migration, apoptosis, and autophagy. Since the ligand binding domains of these receptors have no cavity for ligand
Rukmini Mukherjee et al.
Journal of cell science, 129(4), 757-773 (2016-01-09)
Cellular quality control provides an efficient surveillance system to regulate mitochondrial turnover. This study elucidates a new interaction between the cytosolic E3 ligase mahogunin RING finger 1 (MGRN1) and the endoplasmic reticulum (ER) ubiquitin E3 ligase GP78 (also known as
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