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Showing 1-22 of 22 results for "V1514" within Papers
Katherine E Hekman et al.
Stem cells translational medicine, 11(11), 1151-1164 (2022-09-30)
Stem cells are enabling an improved understanding of the peripheral arterial disease, and patient-specific stem cell-derived endothelial cells (ECs) present major advantages as a therapeutic modality. However, applications of patient-specific induced pluripotent stem cell (iPSC)-derived ECs are limited by rapid
Pengze Yan et al.
Cell stem cell, 24(3), 447-461 (2019-01-22)
FOXO3 is an evolutionarily conserved transcription factor that has been linked to longevity. Here we wanted to find out whether human vascular cells could be functionally enhanced by engineering them to express an activated form of FOXO3. This was accomplished
A lung-on-a-chip array with an integrated bio-inspired respiration mechanism.
Stucki AO
Lab on a chip, 15, 1302-1310 (2015)
Zhi Cheng Xu et al.
Molecular medicine reports, 9(1), 204-210 (2013-11-20)
Hair follicle stem cells (HFSCs) possess powerful expansion and multi‑differentiation potential, properties that place them at the forefront of the field of tissue engineering and stem cell‑based therapy. The aim of the present study was to investigate the differentiation of
Amanda C Ampey et al.
Molecular and cellular endocrinology, 534, 111368-111368 (2021-06-22)
Uterine artery endothelium undergoes a form of functional adaptation during pregnancy because of an increase in Cx43 communication, resulting in increased Ca2+/IP3 exchange and more synchronous and sustained vasodilator production. We have shown previously that acute exposure to growth factors
Thomas Colunga et al.
Cell reports, 26(10), 2566-2579 (2019-03-07)
In this report we describe a human pluripotent stem cell-derived vascular progenitor (MesoT) cell of the mesothelium lineage. MesoT cells are multipotent and generate smooth muscle cells, endothelial cells, and pericytes and self-assemble into vessel-like networks in vitro. MesoT cells transplanted
Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.
Kremmidiotis G
Genomics, 49, 467-471 (1998)
Effects of Morphology vs. Cell?Cell Interactions on Endothelial Cell Stiffness
Stroka KM and Aranda-Espinoza H.
Cellular and Molecular Bioengineering, 4, 9-27 (2011)
Frans van Roy
Nature reviews. Cancer, 14(2), 121-134 (2014-01-21)
Loss of cadherin 1 (CDH1; also known as epithelial cadherin (E-cadherin)) is used for the diagnosis and prognosis of epithelial cancers. However, it should not be ignored that the superfamily of transmembrane cadherin proteins encompasses more than 100 members in
Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and
Venkiteswaran K, et al.
American Journal of Physiology. Cell Physiology (2002)
Loïc Sauteur et al.
Cell reports, 9(2), 504-513 (2014-11-07)
Organ morphogenesis requires the coordination of cell behaviors. Here, we have analyzed dynamic endothelial cell behaviors underlying sprouting angiogenesis in vivo. Two different mechanisms contribute to sprout outgrowth: tip cells show strong migratory behavior, whereas extension of the stalk is dependent upon
Functionally specialized junctions between endothelial cells of lymphatic vessels
Baluk P, et al.
The Journal of Experimental Medicine, 204(10), 2349-2349 (2007)
Cyrill Géraud et al.
PloS one, 7(4), e34206-e34206 (2012-04-18)
Liver sinusoidal endothelium is strategically positioned to control access of fluids, macromolecules and cells to the liver parenchyma and to serve clearance functions upstream of the hepatocytes. While clearance of macromolecular debris from the peripheral blood is performed by liver
Zhenyang Yu et al.
Cardiovascular research, 117(2), 533-546 (2020-02-12)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs), a key component of the endosomal sorting complex required for transport (ESCRT), has been implicated in many essential biological processes. However, the physiological role of endogenous Hgs in the vascular system has not
Xing-Gang Mao et al.
Neuro-oncology, 15(7), 865-879 (2013-05-07)
A proportion of glioblastoma stemlike cells (GSCs) expressing endothelial cell marker CDH5 (vascular-endothelial-cadherin or CD144) can transdifferentiate into endothelial cells and form blood vessels. However, the implications of CDH5 expression in gliomas and how it is regulated in GSCs remain
Manon C A Pronk et al.
Small GTPases, 10(6), 466-484 (2017-09-28)
RhoGTPases are known regulators of intracellular actin dynamics that are important for maintaining endothelial barrier function. RhoA is most extensively studied as a key regulator of endothelial barrier function, however the function of the 2 highly homologous family-members (> 88%)
Risto Kerkelä et al.
Molecular and cellular biology, 33(16), 3321-3329 (2013-06-19)
Small-molecule inhibition of hypoxia-inducible factor prolyl 4-hydroxylases (HIF-P4Hs) is being explored for the treatment of anemia. Previous studies have suggested that HIF-P4H-2 inhibition may also protect the heart from an ischemic insult. Hif-p4h-2(gt/gt) mice, which have 76 to 93% knockdown
Katarzyna Piwowarczyk et al.
Cancers, 10(10) (2018-10-03)
Extravasation of circulating cancer cells is regulated by the intercellular/intracellular signaling pathways that locally impair the endothelial barrier function. Co-cultures of human umbilical vein endothelial cells (HUVECs) with lung adenocarcinoma A549 cells enabled us to identify these pathways and to
Junwen Zhang et al.
Molecular medicine reports, 13(3), 2918-2924 (2016-02-06)
Changes in pulmonary microvascular permeability following cardiopulmonary bypass (CPB) and the underlying mechanisms have not yet been established. Therefore, the aim of the present study was to elucidate the alterations in pulmonary microvascular permeability following CPB and the underlying mechanism.
Katarzyna Piwowarczyk et al.
European journal of cell biology, 96(4), 337-346 (2017-04-12)
Connexin(Cx)43 regulates the invasive potential of prostate cancer cells and participates in their extravasation. To address the role of endothelial Cx43 in this process, we analyzed Cx43 regulation in human umbilical vein endothelial cells in the proximity of Cx43high (DU-145
Charles A Downs et al.
Pulmonary pharmacology & therapeutics, 24(5), 577-586 (2011-06-01)
There is a lack of cell culture models using primary alveolar type I (AT I) cells. The purpose of this study was to develop cell culture models using rat AT I cells and microvascular endothelial cells from the lung (MVECL).
Maria Grazia Lampugnani et al.
Journal of cell science, 123(Pt 7), 1073-1080 (2010-03-25)
Little is known about the molecular mechanisms that regulate the organization of vascular lumen. In this paper we show that lumen formation correlates with endothelial polarization. Adherens junctions (AJs) and VE-cadherin (VEC, encoded by CDH5) are required for endothelial apicobasal
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