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Showing 1-30 of 44 results for "V3640" within Papers
Zoya Marinova et al.
Journal of neurochemistry, 111(4), 976-987 (2009-09-22)
Neuroprotective properties of the mood stabilizer valproic acid (VPA) are implicated in its therapeutic efficacy. Heat-shock protein 70 (HSP70) is a molecular chaperone, neuroprotective and anti-inflammatory agent. This study aimed to investigate underlying mechanisms and functional significance of HSP70 induction
Francesca Toselli et al.
Drug metabolism and disposition: the biological fate of chemicals, 45(8), 966-973 (2017-06-11)
Oxetanyl building blocks are increasingly used in drug discovery because of the improved drug-like properties they confer on drug candidates, yet little is currently known about their biotransformation. A series of oxetane-containing analogs was studied and we provide the first
Akinobu Okada et al.
Birth defects research. Part A, Clinical and molecular teratology, 70(11), 870-879 (2004-11-04)
Valproic acid (VPA) is widely used to treat epilepsy and bipolar disorder and is also a potent teratogen, but its teratogenic mechanisms are unknown. We have attempted to describe a fundamental role of the Polycomb group (Pc-G) in VPA-induced transformations
Zhiqi Xie et al.
Oncoimmunology, 9(1), 1734268-1734268 (2020-03-12)
Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells that promote tumor progression by inhibiting anti-tumor immunity and may be the cause of patient resistance to immune checkpoint inhibitors (ICIs). Therefore, MDSCs are a promising target for cancer immunotherapy, especially in combination
B Praena et al.
Antiviral research, 168, 91-99 (2019-05-28)
Herpes simplex virus type 1 (HSV-1) is a ubiquitous infectious agent that can establish latency in neurons, and in some cases, viral retrograde transport results in infection of the central nervous system (CNS). Several antivirals have been identified with the
Xiao-Chuan Wang et al.
Neurochemical research, 33(6), 1138-1144 (2008-01-31)
In the present study, we have studied the effect of melatonin (Mt) and melatonin derivative, i.e., melatonylvalpromide (Mtv), on cell viability, beta-amyloid (Abeta) production, cell morphology, and expression and phosphorylation of neurofilament proteins in wild-type murine neuroblastoma N2a (N2a/wt) and
Miyuki Takahashi et al.
Biochemical and biophysical research communications, 447(4), 678-682 (2014-04-24)
The cyclin-dependent kinase 5 (Cdk5) is a neuron-specific Ser/Thr kinase that is activated by the regulatory subunit p35. Overactivation of Cdk5, which is induced by the cleavage of p35 by calpain, is implicated in neuronal death in various neurodegenerative diseases.
J A Shimshoni et al.
Molecular pharmacology, 71(3), 884-892 (2006-12-15)
Valproic acid (VPA) is an effective antiepileptic drug with an additional activity for the treatment of bipolar disorder. It has been assumed that both activities arise from a common target. At the molecular level, VPA targets a number of distinct
Chun Yang et al.
Drug metabolism and disposition: the biological fate of chemicals, 47(2), 104-113 (2018-11-18)
Lesinurad [Zurampic; 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)], a selective inhibitor of uric acid reabsorption transporters approved for the treatment of gout, is a racemate of two atropisomers. The objective of this investigation was to evaluate the stereoselectivity of metabolism, the inhibitory potency on kidney
C Payen et al.
Human & experimental toxicology, 23(3), 145-148 (2004-05-04)
As valpromide is a prodrug of valproic acid (valproate), the clinical presentation of overdoses with either valpromide or valproate sodium is generally considered similar. Whereas plasma peak levels and signs of central nervous system depression occur within a few hours
F Condorelli et al.
British journal of pharmacology, 153(4), 657-668 (2007-12-07)
Inhibitors of histone deacetylase (HDAC) are emerging as a promising class of anti-cancer drugs, but a generic deregulation of transcription in neoplastic cells cannot fully explain their therapeutic effects. In this study we evaluated alternative molecular mechanisms by which HDAC
Kamal Prashad Segar et al.
Journal of bioscience and bioengineering, 124(4), 459-468 (2017-06-12)
Process engineering to improve product quality and titers is gaining importance at late-stage cell culture process development. Valproic acid, a US Food and Drug Administration-approved histone deacetylase (HDAC) inhibitor, has been shown to improve cell culture performance with higher productivities
Aileen S W Li et al.
Reproductive toxicology (Elmsford, N.Y.), 66, 68-83 (2016-10-30)
Valproic acid (VPA), an antiepileptic drug, is a teratogen that causes neural tube and axial skeletal defects, although the mechanisms are not fully understood. We previously established a gastrulation model using mouse P19C5 stem cell embryoid bodies (EBs), which exhibits
G Benjelloun et al.
L'Encephale, 30(4), 400-403 (2004-11-13)
Valpromide (VPD) is an antiepileptic drug, derivative of Valproic acid (VPA), used as a mood-stabilizer in bipolar disorder for 25 years in several European countries. VPD is also used as an augmentation strategy in refractory depression. Despite chemical similarity between
Zhong-nan Mao et al.
Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 31(6), 509-512 (2011-07-12)
To compare the efficacy differences between acupoint catgut-embedding combined western medicine (ACCWM) and simple western medicine (WM) for treatment of epilepsy of generalized seizures type. Fifty-two patients with epilepsy of generalized seizures type were randomly divided into an ACCWM group
Akinobu Okada et al.
Birth defects research. Part B, Developmental and reproductive toxicology, 71(1), 47-53 (2004-03-03)
The antiepileptic drug valproic acid (VPA) is well known to cause neural tube and skeletal defects in both humans and animals. The amidic VPA analogues valpromide (VPD) and valnoctamide (VCD) have much lower teratogenicity than VPA inducing exencephaly in mice.
M Bialer
Clinical pharmacokinetics, 20(2), 114-122 (1991-02-01)
Valpromide has been used as an antiepileptic and antipsychotic drug for the past 25 years in several European countries. Unlike its corresponding acid, valproic acid, whose pharmacokinetics have been quite extensively reviewed, and despite years of clinical use, it appears
Diane Commandeur et al.
Annales de biologie clinique, 68(2), 234-238 (2010-03-30)
We report the case of a 35-year-old woman hospitalized in intensive care unit after valpromide self-poisoning (Dépamide). The dose supposed to be taken was 15 g. The patient eleven hours after ingestion, presented, a coma with bilateral non-reactive mydriasis, justifying
Galit Shaltiel et al.
Biological psychiatry, 56(11), 868-874 (2004-12-04)
Lithium and valproate (VPA) are used for treating bipolar disorder. The mechanism of mood stabilization has not been elucidated, but the role of inositol has gained substantial support. Lithium inhibition of inositol monophosphatase, an enzyme required for inositol recycling and
Joseph R Calabrese et al.
Bipolar disorders, 9(6), 628-635 (2007-09-12)
Agomelatine has been shown to be safe and efficient in the treatment of major depressive disorder at 25 mg daily. The aim of this study was to gather preliminary data regarding the antidepressant efficacy of agomelatine in patients with bipolar
Amy J Taylor et al.
Mechanisms of development, 129(9-12), 208-218 (2012-09-06)
Amphibians such as Xenopus laevis and Ambystoma mexicanum are capable of whole structure regeneration. However, transcriptional control over these events is not well understood. Here, we investigate the role of histone deacetylase (HDAC) enzymes in regeneration using HDAC inhibitors. The
Soham Chanda et al.
Cell stem cell, 25(1), 103-119 (2019-06-04)
Human pluripotent stem cells can be rapidly converted into functional neurons by ectopic expression of proneural transcription factors. Here we show that directly reprogrammed neurons, despite their rapid maturation kinetics, can model teratogenic mechanisms that specifically affect early neurodevelopment. We
Reecha D Shah et al.
Journal of cellular biochemistry, 114(4), 854-863 (2012-10-26)
Sodium valproate (VPA) has been recently identified as a selective class I histone deacetylase (HDAC) inhibitor and explored for its potential as an anti-cancer agent. The anti-cancer properties of VPA are generally attributed to its HDAC inhibitory activity indicating a
Lauren E Kernochan et al.
Human molecular genetics, 14(9), 1171-1182 (2005-03-18)
Increasing survival motor neuron 2 (SMN2) gene expression may be an effective strategy for the treatment of spinal muscular atrophy (SMA). Histone deacetylase (HDAC) inhibitors have been shown to increase SMN transcript and protein levels, but the specific role of
Silvina M Tasso et al.
Bioorganic & medicinal chemistry, 12(14), 3857-3869 (2004-06-24)
The antiepileptic activity of nine derivatives of valpromide is discussed. They comply with a pharmacophore model that establishes the essential structural and electronic features responsible for the protection against the MES test. The model results from the comparison of 17
[Valpromide poisoning associated with circulatory collapse].
Benoît Trojak et al.
Therapie, 60(6), 595-597 (2006-03-25)
Karine Cambon et al.
Molecular therapy. Methods & clinical development, 5, 259-276 (2017-06-13)
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder resulting from a polyglutamine expansion in the huntingtin (HTT) protein. There is currently no cure for this disease, but recent studies suggest that RNAi to downregulate the expression of both normal
Romina Aron Badin et al.
Nature communications, 10(1), 4357-4357 (2019-09-27)
Cell therapy products (CTP) derived from pluripotent stem cells (iPSCs) may constitute a renewable, specifically differentiated source of cells to potentially cure patients with neurodegenerative disorders. However, the immunogenicity of CTP remains a major issue for therapeutic approaches based on
John F Eisses et al.
The American journal of pathology, 185(12), 3304-3315 (2015-10-18)
The mechanisms by which drugs induce pancreatitis are unknown. A definite cause of pancreatitis is due to the antiepileptic drug valproic acid (VPA). On the basis of three crucial observations-that VPA inhibits histone deacetylases (HDACs), HDACs mediate pancreas development, and
Ziming Zheng et al.
Carbohydrate polymers, 253, 117255-117255 (2020-12-07)
Lentinan (LNT), a typical triple helix β-glucan, has been widely used as drug and biomaterial. However, its pharmacokinetics in vivo is rarely reported, which severely limits its further development and application. The aim of this study is to establish a
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