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Showing 1-30 of 318 results for "V4505" within Papers
Wolfgang H Ziegler et al.
Trends in cell biology, 16(9), 453-460 (2006-08-09)
Vinculin is a ubiquitously expressed actin-binding protein frequently used as a marker for both cell-cell and cell-extracellular matrix (focal adhesion) adherens-type junctions, but its function has remained elusive. Vinculin is made up of a globular head linked to a tail
Søs Grønbæk Holdgaard et al.
Nature communications, 10(1), 4176-4176 (2019-09-15)
The centrosome is the master orchestrator of mitotic spindle formation and chromosome segregation in animal cells. Centrosome abnormalities are frequently observed in cancer, but little is known of their origin and about pathways affecting centrosome homeostasis. Here we show that
Tong Wen et al.
Cell death and differentiation, 26(12), 2790-2806 (2019-04-27)
TEAD1 (TEA domain transcription factor 1), a transcription factor known for the functional output of Hippo signaling, is important for tumorigenesis. However, the role of TEAD1 in the development of vascular smooth muscle cell (VSMC) is unknown. To investigate cell-specific
Yong Wu et al.
Biochimica et biophysica acta. Molecular basis of disease, 1863(9), 2355-2362 (2017-07-05)
High levels of glucose (HG) induce reactive oxygen species-mediated oxidative stress in endothelial cells (ECs), which leads to endothelial dysfunction and tissue damage. However, the molecular mechanisms involved in HG-induced endothelial oxidative stress and damage remain elusive. Here we show
Louis Tong et al.
Biochimica et biophysica acta, 1833(6), 1304-1315 (2013-03-08)
Migration of cells in the ocular surface underpins physiological wound healing as well as many human diseases. Transglutaminase (TG)-2 is a multifunctional cross-linking enzyme involved in the migration of skin fibroblasts and wound healing, however, its functional role in epithelial
Andrea Hartsock et al.
PloS one, 7(5), e37476-e37476 (2012-06-14)
p120-Catenin binding to, and Hakai-mediated ubiquitination of the E-cadherin juxtamembrane domain (JMD) are thought to be involved in regulating E-cadherin internalization and degradation. However, the relationship between these two pathways is not understood. We targeted the E-cadherin JMD to mitochondria
Sara Fuentelsaz-Romero et al.
Frontiers in immunology, 12, 776879-776879 (2021-11-23)
The identification of "trained immunity/tolerance" in myeloid cells has changed our perception of the performance of monocytes and macrophages during inflammatory and immune responses. Pemetrexed (PMX) and methotrexate (MTX) are blockers of the one-carbon metabolism (OCM) and commonly used therapeutic
R J Pelham et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(25), 13661-13665 (1998-02-12)
Responses of cells to mechanical properties of the adhesion substrate were examined by culturing normal rat kidney epithelial and 3T3 fibroblastic cells on a collagen-coated polyacrylamide substrate that allows the flexibility to be varied while maintaining a constant chemical environment.
Xia Liu et al.
Genesis (New York, N.Y. : 2000), 56(3), e23093-e23093 (2018-02-08)
BMP signaling plays a critical role in craniofacial development. Augmentation of BMPR1A signaling through neural crest-specific expression of constitutively active Bmpr1a (caBmpr1a) results in craniofacial deformities in mice. To investigate whether deletion of Tak1 may rescue the craniofacial deformities caused
Fatmah I Ghuloum et al.
Biomaterials advances, 154, 213652-213652 (2023-10-15)
Polymer microparticles possess great potential as functional building blocks for advanced bottom-up engineering of complex tissues. Tailoring the three-dimensional architectural features of culture substrates has been shown to induce osteogenesis in mesenchymal stem cells in vitro, but the molecular mechanisms
E F Rocnik et al.
The Journal of clinical investigation, 101(9), 1889-1898 (1998-06-13)
Migration of smooth muscle cells (SMCs) and collagen synthesis by SMCs are central to the pathophysiology of vascular disease. Both processes can be induced shortly after vascular injury; however, a functional relationship between them has not been established. In this
Hong Li et al.
Materials (Basel, Switzerland), 14(21) (2021-11-14)
The most appropriate surface treatment to enhance gingival connective tissue formation on the abutment of dental implants remains undefined, with healing associated with a scar-like response. We have previously shown that topographies with an arithmetic average of the absolute profile
J K Crean et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18(13), 1541-1543 (2004-08-21)
Connective tissue growth factor [CTGF]/CCN2 is a prototypic member of the CCN family of regulatory proteins. CTGF expression is up-regulated in a number of fibrotic diseases, including diabetic nephropathy, where it is believed to act as a downstream mediator of
Dominik Ternes et al.
Nature metabolism, 4(4), 458-475 (2022-04-20)
The gut microbiome is a key player in the immunomodulatory and protumorigenic microenvironment during colorectal cancer (CRC), as different gut-derived bacteria can induce tumour growth. However, the crosstalk between the gut microbiome and the host in relation to tumour cell
Tapio Röning et al.
Journal of molecular and cellular cardiology, 164, 148-155 (2021-12-18)
We have previously demonstrated protection against obesity, metabolic dysfunction, atherosclerosis and cardiac ischemia in a hypoxia-inducible factor (HIF) prolyl 4-hydroxylase-2 (Hif-p4h-2) deficient mouse line, attributing these protective effects to activation of the hypoxia response pathway in a normoxic environment. We
Manuela Moriggi et al.
International journal of molecular sciences, 25(13) (2024-07-13)
Pericytes are a distinct type of cells interacting with endothelial cells in blood vessels and contributing to endothelial barrier integrity. Furthermore, pericytes show mesenchymal stem cell properties. Muscle-derived pericytes can demonstrate both angiogenic and myogenic capabilities. It is well known
Chung C W Lee et al.
Journal of the Endocrine Society, 2(12), 1381-1394 (2018-12-12)
Despite the amenability of early-stage prostate cancer to surgery and radiation therapy, locally advanced and metastatic prostate cancer is clinically problematic. Chemical castration is often used as a first-line therapy for advanced disease, but progression to the castration-resistant prostate cancer
Muyu Xu et al.
Biochimica et biophysica acta, 1859(4), 553-563 (2016-01-30)
Gene-specific activation by enhancers involves their communication with the basal RNA polymerase II transcription machinery at the core promoter. Core promoters are diverse and may contain a variety of sequence elements such as the TATA box, the Initiator (INR), and
Rishi R Agrawal et al.
Cellular and molecular neurobiology (2022-12-27)
Traumatic brain injury (TBI) can lead to neurodegenerative diseases such as Alzheimer's disease (AD) through mechanisms that remain incompletely characterized. Similar to AD, TBI models present with cellular metabolic alterations and modulated cleavage of amyloid precursor protein (APP). Specifically, AD
Sabrina Rizzolio et al.
Cancer research, 78(4), 1058-1068 (2017-12-13)
Neuropilins are a class of cell surface proteins implicated in cell migration and angiogenesis, with aberrant expression in human tumors. Here, we show that the expression of Neuropilin-2 (NRP2) controls EGFR protein levels, thereby impinging on intracellular signaling, viability, and
Xiaofei Li et al.
Development (Cambridge, England), 150(2) (2023-01-10)
The cardiomyocyte phenotypic switch from a proliferative to terminally differentiated state results in the loss of regenerative potential of the mammalian heart shortly after birth. Nonmuscle myosin IIB (NM IIB)-mediated actomyosin contractility regulates cardiomyocyte cytokinesis in the embryonic heart, and
Pablo Mendoza et al.
Journal of cell science, 126(Pt 17), 3835-3847 (2013-07-03)
Migration and invasion are essential steps associated with tumor cell metastasis and increasing evidence points towards endosome trafficking being essential in this process. Indeed, the small GTPase Rab5, a crucial regulator of early endosome dynamics, promotes cell migration in vitro
Angika Basant et al.
Microbiology spectrum, 11(6), e0152923-e0152923 (2023-10-19)
Vaccinia virus is a large double-stranded DNA virus and a close relative of Mpox and Variola virus, the causative agent of smallpox. During infection, Vaccinia hijacks its host's transport systems and promotes its spread into neighboring cells by recruiting a
Christina V Angeles et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 28(1), 175-186 (2021-10-21)
Dedifferentiated liposarcoma (DDLS), one of the most common and aggressive sarcomas, infrequently responds to chemotherapy. DDLS survival and growth depend on underexpression of C/EBPα, a tumor suppressor and transcriptional regulator controlling adipogenesis. We sought to screen and prioritize candidate drugs
Chao Mao et al.
Nature, 593(7860), 586-590 (2021-05-14)
Ferroptosis, a form of regulated cell death that is induced by excessive lipid peroxidation, is a key tumour suppression mechanism1-4. Glutathione peroxidase 4 (GPX4)5,6 and ferroptosis suppressor protein 1 (FSP1)7,8 constitute two major ferroptosis defence systems. Here we show that
Laura A Smith Callahan et al.
Biomacromolecules, 14(9), 3047-3054 (2013-07-13)
Stem cells have shown lineage-specific differentiation when cultured on substrates possessing signaling groups derived from the native tissue. A distinct determinant in this process is the concentration of the signaling motif. While several groups have been working actively to determine
Joell L Solan et al.
Oncogene, 40(10), 1909-1920 (2021-02-20)
Pancreatic ductal adenocarcinoma (PDA) is aggressive, highly metastatic and characterized by a robust desmoplasia. Connexin proteins that form gap junctions have been implicated in tumor suppression for over 30 years. Cx43, the most widely expressed connexin, regulates cell behaviors, including
Yohei Kawakami et al.
Molecular therapy. Methods & clinical development, 14, 64-76 (2019-07-18)
Aging-related loss of adult stem cell function contributes to impaired tissue regeneration. Mice deficient in zinc metalloproteinase STE24 (Zmpste24-/-) exhibit premature age-related musculoskeletal pathologies similar to those observed in children with Hutchinson-Gilford progeria syndrome (HGPS). We have reported that muscle-derived
Jian Hu et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(36), 14520-14527 (2013-08-07)
An immature state of cellular differentiation--characterized by stem cell-like tendencies and impaired differentiation--is a hallmark of cancer. Using glioblastoma multiforme (GBM) as a model system, we sought to determine whether molecular determinants that drive cells toward terminal differentiation are also
B Bouzahzah et al.
Molecular medicine (Cambridge, Mass.), 7(12), 816-830 (2002-02-15)
Relatively few genes have been shown to directly affect the metastatic phenotype of breast cancer epithelial cells in vivo. The Rho family of proteins, incluing the Rho, Rac and Cdc42 subfamilies, are related to the small GTP binding protein Ras
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