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Showing 1-30 of 135 results for "V8012" within Papers
Maria Derkacheva et al.
The EMBO journal, 32(14), 2073-2085 (2013-06-20)
Polycomb group (PcG) proteins form essential epigenetic memory systems for controlling gene expression during development in plants and animals. However, the mechanism of plant PcG protein functions remains poorly understood. Here, we probed the composition and function of plant Polycomb
Zoë A Feder et al.
The Journal of cell biology, 220(1) (2020-12-17)
Cells exposed to heat shock induce a conserved gene expression program, the heat shock response (HSR), encoding protein homeostasis (proteostasis) factors. Heat shock also triggers proteostasis factors to form subcellular quality control bodies, but the relationship between these spatial structures
Vivian Delcourt et al.
EBioMedicine, 21, 55-64 (2017-06-21)
Recently, it was demonstrated that proteins can be translated from alternative open reading frames (altORFs), increasing the size of the actual proteome. Top-down mass spectrometry-based proteomics allows the identification of intact proteins containing post-translational modifications (PTMs) as well as truncated
María Florencia Ogara et al.
Biochimica et biophysica acta, 1843(7), 1309-1324 (2014-04-08)
DNA damage, which perturbs genomic stability, has been linked to cognitive decline in the aging human brain, and mutations in DNA repair genes have neurological implications. Several studies have suggested that DNA damage is also increased in brain disorders such
Rui Ye et al.
The Journal of biological chemistry, 286(29), 25891-25902 (2011-05-27)
The current consensus model for the circadian clock in mammals is based on a transcription-translation feedback loop. In this model, CRY and PER proteins repress their own transcription by suppressing the transactivator function of the CLOCK:BMAL1 heterodimer directly (physical model)
Heidi A Butz et al.
mBio, 10(3) (2019-06-06)
CsrA, an RNA-binding global regulator, is an essential protein in Vibrio choleraeV. cholerae CsrA is regulated by three small RNAs (sRNAs), namely, CsrB, CsrC, and CsrD, which act to sequester and antagonize the activity of CsrA. Although the sRNAs were
Xinjun Zhang et al.
The Journal of biological chemistry, 291(5), 2435-2443 (2015-12-04)
The Wnt family of secreted glycolipoproteins plays pivotal roles in development and human diseases. Tiki family proteins were identified as novel Wnt inhibitors that act by cleaving the Wnt amino-terminal region to inactivate specific Wnt ligands. Tiki represents a new
Shengqiang Xu et al.
PloS one, 9(7), e100824-e100824 (2014-07-06)
Apoptosis-inducing factor (AIF) plays a crucial role in caspase-independent programmed cell death by triggering chromatin condensation and DNA fragmentation. Therefore, it might be involved in cell homeostasis and tumor development. In this study, we report significant AIF downregulation in the
Daniel P Ball et al.
Science immunology, 7(77), eabm7200-eabm7200 (2022-11-05)
The danger signals that activate the NLRP1 inflammasome have not been established. Here, we report that the oxidized, but not the reduced, form of thioredoxin-1 (TRX1) binds to NLRP1. We found that oxidized TRX1 associates with the NACHT-LRR region of
Jiao Wang et al.
EMBO reports, 18(3), 437-450 (2017-02-09)
Protein phosphatase 2A (PP2A) is a critical human tumor suppressor. Cancerous inhibitor of PP2A (CIP2A) supports the activity of several critical cancer drivers (Akt, MYC, E2F1) and promotes malignancy in most cancer types via PP2A inhibition. However, the 3D structure
Ki-Hyun Kim et al.
Molecular and cellular biology, 33(10), 2078-2090 (2013-03-20)
Liver fibrosis occurs as a wound-healing response to chronic hepatic injuries irrespective of the underlying etiology and may progress to life-threatening cirrhosis. Here we show that CCN1, a matricellular protein of the CCN (CYR61/CTGF/NOV) family, is accumulated in hepatocytes of
Bei Wang et al.
Frontiers in microbiology, 12, 684953-684953 (2021-05-29)
Enterovirus 71 (EV71) is the major causative pathogen of hand, foot, and mouth disease. The lack of understanding of the virus's pathogenesis hinders the development of anti-virus drugs and the control of EV71 infection. Our previous studies have demonstrated that
Maria Benitez-Guijarro et al.
The EMBO journal, 37(15) (2018-07-01)
Long INterspersed Element class 1 (LINE-1) elements are a type of abundant retrotransposons active in mammalian genomes. An average human genome contains ~100 retrotransposition-competent LINE-1s, whose activity is influenced by the combined action of cellular repressors and activators. TREX1, SAMHD1
Frank Sleutels et al.
Epigenetics & chromatin, 5(1), 8-8 (2012-06-20)
CTCF is a highly conserved and essential zinc finger protein expressed in virtually all cell types. In conjunction with cohesin, it organizes chromatin into loops, thereby regulating gene expression and epigenetic events. The function of CTCFL or BORIS, the testis-specific
Munmun Chowdhury et al.
Developmental and comparative immunology, 95, 50-58 (2019-02-09)
An important innate immune response in Drosophila melanogaster is the production of antimicrobial peptides (AMPs). Expression of AMP genes is mediated by the Toll and immune deficiency (IMD) pathways via NF-κB transcription factors Dorsal, DIF and Relish. Dorsal and DIF
Weiyu Luo et al.
PLoS pathogens, 14(1), e1006851-e1006851 (2018-01-21)
Transcription and replication of the influenza A virus (IAV) genome occur in the nucleus of infected cells and are carried out by the viral ribonucleoprotein complex (vRNP). As a major component of the vRNP complex, the viral nucleoprotein (NP) mediates
Ting-Fang Lee et al.
Biochimica et biophysica acta. Molecular cell research, 1868(2), 118891-118891 (2020-10-24)
Lung cancer is the leading cause of cancer death, and therefore the discovery of novel therapeutic targets is crucial. P21-activated kinase (PAK1) is an important oncogene involved in the signaling of actin cytoskeleton organization. Although PAK1 inhibition has been shown
Bryan T MacDonald et al.
The Journal of biological chemistry, 289(26), 18122-18136 (2014-05-21)
Secreted Wnt lipoproteins are cysteine-rich and lipid-modified morphogens that bind to the Frizzled (FZD) receptor and LDL receptor-related protein 6 (LRP6). Wnt engages FZD through protruding thumb and index finger domains, which are each assembled from paired β strands secured
Sun-Young Kim et al.
Applied and environmental microbiology, 89(5), e0033523-e0033523 (2023-04-20)
Small proteins perform a diverse array of functions, from microbial competition, to endocrine signaling, to building biomaterials. Microbial systems that can produce recombinant small proteins enable discovery of new effectors, exploration of sequence activity relationships, and have the potential for
Kai Wu et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(42), E9889-E9898 (2018-10-03)
Human CMV (HCMV) exhibits a broad cell tropism that depends on two virion glycoprotein complexes: a trimeric complex (gH/gL/gO) that facilitates viral infection primarily in fibroblasts and a pentameric complex (gH/gL/pUL128-pUL130-pUL131A) that mediates infection in epithelial and endothelial cells. We
Julia Fueller et al.
The Journal of cell biology, 219(6) (2020-05-15)
Here we describe a time-efficient strategy for endogenous C-terminal gene tagging in mammalian tissue culture cells. An online platform is used to design two long gene-specific oligonucleotides for PCR with generic template cassettes to create linear dsDNA donors, termed PCR
Merve Deniz Abdusselamoglu et al.
eLife, 8 (2019-07-23)
Neural progenitors undergo temporal patterning to generate diverse neurons in a chronological order. This process is well-studied in the developing Drosophila brain and conserved in mammals. During larval stages, intermediate neural progenitors (INPs) serially express Dichaete (D), grainyhead (Grh) and
Asma Mechakra et al.
The American journal of cardiology, 123(5), 787-793 (2018-12-19)
Genome-wide studies have associated several genetic variants upstream of PITX2 on chromosome 4q25 with atrial fibrillation (AF), suggesting a potential role of PITX2 in AF. Our study aimed at identifying rare coding variants in PITX2 predisposing to AF. The Polymerase
Penny M Anders et al.
PLoS pathogens, 12(11), e1005985-e1005985 (2016-11-10)
Kaposi's sarcoma herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS) as well as two lymphoproliferative diseases, primary effusion lymphoma and multicentric Castleman's disease. KSHV encodes viral proteins, such as K1, that alter signaling pathways involved in cell survival.
Felix D Weiss et al.
Nature communications, 12(1), 2919-2919 (2021-05-20)
Cornelia de Lange Syndrome (CdLS) is a human developmental disorder caused by mutations that compromise the function of cohesin, a major regulator of 3D genome organization. Cognitive impairment is a universal and as yet unexplained feature of CdLS. We characterize
Shuang Tao et al.
Journal of experimental & clinical cancer research : CR, 42(1), 194-194 (2023-08-05)
RNA binding proteins (RBPs)-regulated gene expression play a vital role in various pathological processes, including the progression of cancer. However, the role of RBP in hepatocellular carcinoma (HCC) remains much unknown. In this study, we aimed to explore the contribution
Yongzhi Hua et al.
Frontiers in immunology, 13, 932268-932268 (2022-08-02)
Negative regulators of the inflammatory responses are essential for the maintenance of immune homeostasis and organismal fitness. In Drosophila, the deubiquitinase (Dub) dTrbd selectively restricts the K63-linked ubiquitination modification of dTak1, a pivotal kinase of the IMD signaling pathway, to
Measurement of bioactive osteocalcin in humans using a novel immunoassay reveals association with glucose metabolism and $\beta$-cell function
Lacombe J, et al.
American Journal of Physiology. Endocrinology and Metabolism, 318(3), E381-E391 (2020)
Andreas M F Heilmann et al.
Journal of virology, 84(19), 9920-9931 (2010-07-16)
The switch from Epstein-Barr virus (EBV) latent infection to lytic replication is governed by two viral transactivators, Zta and Rta. We previously reported that the EBV protein LF2 binds Rta, inhibits Rta promoter activation, and blocks EBV replication in cells.
Sandra Bermeo et al.
Journal of cellular biochemistry, 118(12), 4425-4435 (2017-04-28)
Mutations in MAN1, a protein of the nuclear envelope, cause bone phenotypes characterized by hyperostosis. The mechanism of this pro-osteogenic phenotype remains unknown. We increased and decreased MAN1 expression in mesenchymal stem cells (MSC) upon which standard osteogenic and adipogenic
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