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Showing 1-30 of 279 results for "V9264" within Papers
Gwen R Buel et al.
The Journal of biological chemistry, 298(6), 102030-102030 (2022-05-17)
The mechanistic target of rapamycin complex 1 (mTORC1) is a serine/threonine kinase complex that promotes anabolic processes including protein, lipid, and nucleotide synthesis, while suppressing catabolic processes such as macroautophagy. mTORC1 activity is regulated by growth factors and amino acids
Wiskott-Aldrich syndrome protein interacts and inhibits diacylglycerol kinase alpha promoting IL-2 induction.
Velnati, et al.
Frontiers in Immunology, 14, 1043603-1043603 (2023)
Costanza Giampietro et al.
The Journal of cell biology, 211(6), 1177-1192 (2015-12-17)
Vascular endothelial (VE)-cadherin transfers intracellular signals contributing to vascular hemostasis. Signaling through VE-cadherin requires association and activity of different intracellular partners. Yes-associated protein (YAP)/TAZ transcriptional cofactors are important regulators of cell growth and organ size. We show that EPS8, a
Esther Marchena-Cruz et al.
Cell reports, 42(3), 112148-112148 (2023-02-25)
Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic approaches and cellular analysis of specific mutants have uncovered factors potentially involved in R-loop homeostasis, we report a more open screening of
Yashoda Chandorkar et al.
Nature communications, 10(1), 4027-4027 (2019-09-08)
Cells feel the forces exerted on them by the surrounding extracellular matrix (ECM) environment and respond to them. While many cell fate processes are dictated by these forces, which are highly synchronized in space and time, abnormal force transduction is
Melanie Vogler et al.
PloS one, 8(7), e69128-e69128 (2013-07-23)
Cells can adapt to hypoxia by various mechanisms. Yet, hypoxia-induced effects on the cytoskeleton-based cell architecture and functions are largely unknown. Here we present a comprehensive analysis of the architecture and function of L929 fibroblasts under hypoxic conditions (1% O2).
Maria Carmela Filomena et al.
eLife, 10 (2021-09-25)
Myopalladin (MYPN) is a striated muscle-specific immunoglobulin domain-containing protein located in the sarcomeric Z-line and I-band. MYPN gene mutations are causative for dilated (DCM), hypertrophic, and restrictive cardiomyopathy. In a yeast two-hybrid screening, MYPN was found to bind to titin
Eliene Albers et al.
Cell reports, 24(12), 3274-3284 (2018-09-21)
PICH is a DNA translocase necessary for the resolution of ultrafine anaphase DNA bridges and to ensure the fidelity of chromosomal segregation. Here, we report the generation of an animal model deficient for PICH that allowed us to investigate its
Nataliya Basalova et al.
Non-coding RNA, 9(5) (2023-09-22)
Non-coding RNA (ncRNAs) genes have attracted increasing attention in recent years due to their widespread involvement in physiological and pathological processes and regulatory networks. The study of the function and molecular partners of ncRNAs opens up opportunities for the early
Andrea David Re Cecconi et al.
Cancers, 14(7) (2022-04-13)
Cancer cachexia consists of dramatic body weight loss with rapid muscle depletion due to imbalanced protein homeostasis. We found that the mRNA levels of apelin decrease in muscles from cachectic hepatoma-bearing rats and three mouse models of cachexia. Furthermore, apelin
Elizabeth A Brooks et al.
ACS biomaterials science & engineering, 4(2), 707-718 (2018-02-12)
Tunable biomaterials that mimic selected features of the extracellular matrix (ECM) such as its stiffness, protein composition, and dimensionality are increasingly popular for studying how cells sense and respond to ECM cues. In the field, there exists a significant trade-off
Tanya Schild et al.
Cell reports, 35(11), 109238-109238 (2021-06-17)
Metabolic adaptations and the signaling events that control them promote the survival of pancreatic ductal adenocarcinoma (PDAC) at the fibrotic tumor site, overcoming stresses associated with nutrient and oxygen deprivation. Recently, rewiring of NADPH production has been shown to play
Shotaro Sakakibara et al.
The Journal of cell biology, 219(5) (2020-04-01)
Actomyosin-undercoated adherens junctions are critical for epithelial cell integrity and remodeling. Actomyosin associates with adherens junctions through αE-catenin complexed with β-catenin and E-cadherin in vivo; however, in vitro biochemical studies in solution showed that αE-catenin complexed with β-catenin binds to
Claudia Tonelli et al.
Oncotarget, 6(28), 24611-24626 (2015-09-16)
The tumor suppressor p53 is a transcription factor that coordinates the cellular response to DNA damage. Here we provide an integrated analysis of p53 genomic occupancy and p53-dependent gene regulation in the splenic B and non-B cell compartments of mice
Ana P Gomes et al.
Cancer cell, 36(4), 402-417 (2019-10-01)
Metastasis is the leading cause of cancer mortality. Chromatin remodeling provides the foundation for the cellular reprogramming necessary to drive metastasis. However, little is known about the nature of this remodeling and its regulation. Here, we show that metastasis-inducing pathways
Salima Nedjari et al.
Journal of tissue engineering and regenerative medicine, 14(10), 1428-1437 (2020-07-18)
Mimicking the complex organization of the extracellular matrix (ECM), especially its structure and dimensionality, is necessary to produce living tissues from stem cells. In compliance with a previously established role of nanofiber organization for the osteogenic differentiation of stem cells
Yan Wang et al.
Frontiers in cardiovascular medicine, 7, 582890-582890 (2020-12-17)
Cardiac hypertrophy is a pathophysiological response to harmful stimuli. The continued presence of cardiac hypertrophy will ultimately develop into heart failure. The mitochondrion is the primary organelle of energy production, and its dysfunction plays a crucial role in the progressive
Sarah K Gersing et al.
PLoS genetics, 17(4), e1009539-e1009539 (2021-04-30)
Canavan disease is a severe progressive neurodegenerative disorder that is characterized by swelling and spongy degeneration of brain white matter. The disease is genetically linked to polymorphisms in the aspartoacylase (ASPA) gene, including the substitution C152W. ASPA C152W is associated
Madeline A Lancaster et al.
Nature, 501(7467), 373-379 (2013-09-03)
The complexity of the human brain has made it difficult to study many brain disorders in model organisms, highlighting the need for an in vitro model of human brain development. Here we have developed a human pluripotent stem cell-derived three-dimensional
Bart Kolendowski et al.
Cells, 9(11) (2020-11-07)
Ovarian clear cell carcinoma (OCCC) is a rare subtype of gynecological cancer for which well-characterized and authenticated model systems are scarce. We provide an extensive characterization of '105C', a cell line generated from an adenocarcinoma of the clear cell histotype
Edouard Mullarky et al.
Proceedings of the National Academy of Sciences of the United States of America, 113(7), 1778-1783 (2016-02-03)
Cancer cells reprogram their metabolism to promote growth and proliferation. The genetic evidence pointing to the importance of the amino acid serine in tumorigenesis is striking. The gene encoding the enzyme 3-phosphoglycerate dehydrogenase (PHGDH), which catalyzes the first committed step
Biomimetic calcium carbonate concentric microgrooves with tunable widths for promoting MC3T3-E1 cell functions
Wu X and Wang S
Advanced Helathcare Materials, 2(2), 326-333 (2013)
Josef Večeřa et al.
Stem cells international, 2017, 8715798-8715798 (2018-02-10)
Extensive research in the field of stem cells and developmental biology has revealed evidence of the role of hypoxia as an important factor regulating self-renewal and differentiation. However, comprehensive information about the exact hypoxia-mediated regulatory mechanism of stem cell fate
Kinga Tylek et al.
Cells, 12(21) (2023-11-10)
Microglial cells have been demonstrated to be significant resident immune cells that maintain homeostasis under physiological conditions. However, prolonged or excessive microglial activation leads to disturbances in the resolution of inflammation (RoI). Formyl peptide receptor 2 (FPR2) is a crucial
Archana Bommi-Reddy et al.
PloS one, 17(3), e0262378-e0262378 (2022-03-31)
Therapeutic targeting of the estrogen receptor (ER) is a clinically validated approach for estrogen receptor positive breast cancer (ER+ BC), but sustained response is limited by acquired resistance. Targeting the transcriptional coactivators required for estrogen receptor activity represents an alternative
V J Sanchez-Arévalo Lobo et al.
Oncogene, 32(45), 5261-5271 (2013-01-16)
The tyrosine kinase c-Abl (or Abl) and the prolyl-isomerase Pin1 cooperatively activate the transcription factor p73 by enhancing recruitment of the acetyltransferase p300. As the transcription factor c-Myc (or Myc) is a known target of Pin1 and p300, we hypothesized
Christian Schölz et al.
Nature biotechnology, 33(4), 415-423 (2015-03-10)
Lysine deacetylases inhibitors (KDACIs) are used in basic research, and many are being investigated in clinical trials for treatment of cancer and other diseases. However, their specificities in cells are incompletely characterized. Here we used quantitative mass spectrometry (MS) to
Andrea David Re Cecconi et al.
Journal of cachexia, sarcopenia and muscle, 13(4), 2225-2241 (2022-05-26)
The p97 complex participates in the degradation of muscle proteins during atrophy upon fasting or denervation interacting with different protein adaptors. We investigated whether and how it might also be involved in muscle wasting in cancer, where loss of appetite
Jason D Roh et al.
Science translational medicine, 11(482) (2019-03-08)
Activin type II receptor (ActRII) ligands have been implicated in muscle wasting in aging and disease. However, the role of these ligands and ActRII signaling in the heart remains unclear. Here, we investigated this catabolic pathway in human aging and
A kindred with mutant IKAROS and autoimmunity.
Erika Van Nieuwenhove et al.
The Journal of allergy and clinical immunology, 142(2), 699-702 (2018-05-01)
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