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Showing 1-30 of 247 results for "W398500" within Papers
Matthew Di Rago et al.
Forensic science international, 243, 35-43 (2014-05-06)
The aim of this study was to develop an LC-MS/MS based screening technique that covers a broad range of acidic and neutral drugs and poisons by combining a small sample volume and efficient extraction technique with simple automated data processing.
Kyle W Bender et al.
The Biochemical journal, 457(1), 127-136 (2013-10-10)
Many signalling pathways in plants are regulated by the second messenger calcium (Ca(2+)). In the standard model, Ca(2+)-sensor proteins, such as CaM (calmodulin), detect Ca(2+) signals and subsequently regulate downstream targets to advance the signal transduction cascade. In addition to
Lawrence Green et al.
Journal of drugs in dermatology : JDD, 12(2), 180-185 (2013-02-05)
Acne vulgaris is a common dermatologic disease that most frequently affects adolescents and young adults. Over-the-counter (OTC) acne treatment regimens are increasingly being used by individuals with acne. To compare the efficacy, user satisfaction, and tolerability of the OTC regimens
Magdalena Kotzé et al.
AAPS PharmSciTech, 16(4), 835-845 (2015-01-13)
Oil-in-water (o/w) emulsions are commonly converted into solid-like powders in order to improve their physical and chemical stabilities. The aim of this study was to investigate whether whey protein/polysaccharide-stabilized o/w emulsions could be converted into stable oil powders by means
Shunping Yan et al.
Molecular cell, 52(4), 602-610 (2013-11-12)
DNA damage is normally detrimental to living organisms. Here we show that it can also serve as a signal to promote immune responses in plants. We found that the plant immune hormone salicylic acid (SA) can trigger DNA damage in
Jinyoung Kwak et al.
Langmuir : the ACS journal of surfaces and colloids, 29(14), 4477-4484 (2013-03-20)
Photoluminescent spherical nanostructures were prepared through the self-assembly of a tyrosine-containing bolaamphiphilic molecule, and their antenna effect was examined. The photoluminescent spherical nanostructures were simply prepared by self-assembly of bolaamphiphile molecules in an aqueous solution in which water-soluble photosensitizers and
Ping Huang et al.
Plant science : an international journal of experimental plant biology, 203-204, 98-106 (2013-02-19)
Plant receptor-like protein kinases are thought to be involved in various cellular processes mediated by signal transduction pathways. There are about 45 lectin receptor kinases in Arabidopsis, but only a few have been studied. Here, we investigated the effect of
Masanori Matsuoka et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 31(7), 629-634 (2015-07-15)
This paper for the first time reports on novel and non-enzymatic method for studying the free radical-scavenging properties of phenolic compounds against superoxide anion radicals (O2·(-)) by using the cathodic electrochemiluminescence (ECL) of lucigenin (Luc(2+)). The ECL of Luc(2+) at
Jose Pedro Fonseca et al.
PloS one, 9(12), e114119-e114119 (2014-12-02)
Nudix hydrolases comprise a large gene family of twenty nine members in Arabidopsis, each containing a conserved motif capable of hydrolyzing specific substrates like ADP-glucose and NADH. Until now only two members of this family, AtNUDX6 and AtNUDX7, have been
A Corina Vlot et al.
Annual review of phytopathology, 47, 177-206 (2009-04-30)
For more than 200 years, the plant hormone salicylic acid (SA) has been studied for its medicinal use in humans. However, its extensive signaling role in plants, particularly in defense against pathogens, has only become evident during the past 20
Suneela S Dhaneshwar et al.
European journal of medicinal chemistry, 44(10), 3922-3929 (2009-05-16)
Colon-specific mutual azo prodrugs of 5-aminosalicylic acid with essential amino acids were synthesized for the management of inflammatory bowel disease. The structures were confirmed by elemental and spectral analyses. 85-88% release of 5-aminosalicylic acid was achieved in rat fecal matter
Michelle A Ouimet et al.
Macromolecular bioscience, 15(3), 342-350 (2014-10-22)
Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In
Mathias Herrmann
The Journal of clinical investigation, 112(2), 149-151 (2003-07-17)
Aspirin has been shown to cause a reduction in the virulence of Staphylococcus aureus-associated endocarditis. A new study reveals that salicylic acid, the major metabolite of aspirin, acts at the level of transcription to downregulate the production of fibrinogen, fibronectin
Salicylic acid as a peeling agent: a comprehensive review.
Clinical, cosmetic and investigational dermatology, 8, 455-455 (2015)
Bo Liu et al.
PloS one, 9(7), e102067-e102067 (2014-07-11)
Biotic and abiotic stresses are major unfavorable factors that affect crop productivity worldwide. NAC proteins comprise a large family of transcription factors that play important roles in plant growth and development as well as in responses to biotic and abiotic
Cristina Avonto et al.
Toxicology and applied pharmacology, 289(2), 177-184 (2015-10-13)
Skin sensitization is an important toxicological end-point in the risk assessment of chemical allergens. Because of the complexity of the biological mechanisms associated with skin sensitization, integrated approaches combining different chemical, biological and in silico methods are recommended to replace
Ashish Ranjan et al.
Functional & integrative genomics, 15(3), 363-373 (2014-12-17)
Xanthomonas oryzae pv. oryzae, the causal agent of bacterial blight of rice, secretes several cell wall degrading enzymes including cellulase (ClsA) and lipase/esterase (LipA). Prior treatment of rice leaves with purified cell wall degrading enzymes such as LipA can confer
Andrés Olivares-Morales et al.
The AAPS journal, 17(5), 1177-1192 (2015-05-20)
Regional intestinal effective permeability (P(eff)) values are key for the understanding of drug absorption along the whole length of the human gastrointestinal (GI) tract. The distal regions of the GI tract (i.e. ileum, ascending-transverse colon) represent the main sites for
Rajeev Kumar Kapoor et al.
Bioresource technology, 189, 99-106 (2015-04-16)
Laccases have wide range of substrate specificity and find applications from pulp industry to waste water remediation. Laccases have also been used in combined pretreatment of biomass hydrolyzates to remove enzymatic and fermentation inhibitors. In this study, laccase production by
A Kunkel et al.
Archiv der Pharmazie, 332(5), 175-178 (1999-06-15)
Capillary electrophoresis (CE) is often regarded as a separation technique of choice because of its high selectivity and its cost advantages compared to LC.RSD% of 0.5% have become standard for quality control assays. Using CE, sample pretreatment can often be
Guozhang Kang et al.
Molecular genetics and genomics : MGG, 288(11), 591-599 (2013-08-15)
Basic transcription factor 3 (BTF3), the β-subunit of the nascent polypeptide-associated complex, is responsible for the transcriptional initiation of RNA polymerase II and is also involved in cell apoptosis, translation initiation regulation, growth, development, and other functions. Here, we report
Thorsten E Fisher et al.
Bioorganic & medicinal chemistry letters, 17(23), 6511-6515 (2007-10-13)
A series of potent novel 8-hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors was identified. These compounds inhibited the strand transfer process of HIV-1 integrase and viral replication in cells. Compound 12 is active against replication of HIV-1 in cell culture with a CIC(95)
Themba T Ndovi et al.
Clinical pharmacology and therapeutics, 80(2), 146-158 (2006-08-08)
The male genital tract is a complex collection of anatomically and biochemically distinct compartments that contribute to the ejaculate. Understanding the pharmacokinetics in these compartments should inform rational therapeutics involving these glands. Nineteen men were administered a single dose of
Sylwia Magiera et al.
Journal of AOAC International, 97(6), 1526-1537 (2015-01-30)
A rapid and sensitive ultra-HPLC/MSIMS (UHPLC/MSIMS) assay method for the simultaneous determination in human urine of 22 drugs belonging to different pharmaceutical groups was developed. The drugs were extracted from urine samples and then separated on a Zorbax Rapid Resolution
Michael Groszmann et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(46), E6397-E6406 (2015-11-04)
Plant hybrids are extensively used in agriculture to deliver increases in yields, yet the molecular basis of their superior performance (heterosis) is not well understood. Our transcriptome analysis of a number of Arabidopsis F1 hybrids identified changes to defense and
Pankaj Aggarwal et al.
Journal of chromatography. A, 1364, 96-106 (2014-09-07)
Highly cross-linked monolithic networks (i.e., polyethylene glycol diacrylate, PEGDA) synthesized from monomers containing varying ethylene oxide chain lengths were fabricated inside fused silica capillary columns for use in liquid chromatography (LC) of small molecules. Tergitol was used as a surfactant
Ganesan Karthikeyan et al.
British journal of haematology, 146(2), 142-149 (2009-05-15)
Guidelines differ on whether acetyl salicylic acid (ASA, aspirin) should be used for prophylaxis in patients at high-risk of venous thromboembolism (VTE), principally because of differences in perceptions of its efficacy. ASA is an attractive therapeutic option because it is
Artem O Surov et al.
Molecular pharmaceutics, 12(11), 4154-4165 (2015-10-20)
Salts of the antiviral drug Arbidol (umifenovir) with pharmaceutically relevant benzoate and salicylate anions were obtained, and their crystal structures were described. For Arbidol salicylate, an unstable solvate with acetonitrile was also found and characterized. Analysis of the conformational preferences
N H Yoshida et al.
The Journal of pharmacy and pharmacology, 47(11), 883-890 (1995-11-01)
Solute concentration, buffer concentration, applied pH and buffer constituents affect the cathodal iontophoresis of salicylate, benzoate and butyrate across excised skin. Experiments were conducted in which the iontophoretic flux of salicylate was measured across excised human skin with variations in
[10-year-old boy with blackish brown skin alterations].
C Guarneri et al.
Deutsche medizinische Wochenschrift (1946), 139(50), 2585-2586 (2014-12-04)
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