Zinc finger CCCH-type containing 10

Data Sheet - T5327

a family of human ARE (AU-rich element found in 3’ UTR mRNA) binding protein that contains tandem CCCH zinc finger RNA-binding domains required for interaction with ARE. ARE sequences function as instability

Data Sheet - T5452

a family of human ARE (AU-rich element found in 3’ UTR mRNA) binding protein that contains tandem CCCH zinc finger RNA-binding domains required for interaction with ARE. ARE sequences function as instability

Examination of Non-Specifically Bound Proteins and Peptides Following Depletion of Twenty High Abundance Proteins from Human Plasma

Melanoma-derived leucine zipper-containing extranuclear factor 50 1 50 1 50 1 50 1 50 1 49 1 IPI00298971 Vitronectin precursor 51 1 112 2 99 2 IPI00329547 Zinc finger CCCH domain-containing protein 13 50 1 50

CompoZr Custom Zinc Finger Activators

effector domains Standard format for ZF-TF delivery is via the plasmid containing the p65 activation domain. Zinc finger motifs are cloned 5’ of this sequence using Acc65I and BamHI sites (see Figure

Biowire Fall 2010 - Breakthroughs in Biology

consist of two domains, a zinc finger DNA binding domain and a catalytic nuclease domain (Figure 1). The zinc finger domains used here are derived from the Cys(2)-His(2) zinc finger proteins that each recognize

Product Information Sheet - CSTZFN

CompoZr ZFN mRNAs are between 1,200 and 1,500 nt in length, dependent on how many zinc fingers the construct contains. Alternatively, RNA quality can be evaluated on agarose gel along with appropriate

Product Information Sheet - ZFNGS

chain of zinc finger proteins and a DNA-cleaving domain comprised of the nuclease domain of FokI. Each zinc finger DNA binding protein recognizes a 3 base pair target. By combining 4-6 zinc finger proteins

Product Information Sheet - ZFNDHFR

chain of zinc finger proteins and a DNA-cleaving domain comprised of the nuclease domain of FokI. Each zinc finger DNA binding protein recognizes a 3 base pair target. By combining 4-6 zinc finger proteins

Data Sheet - S4319

confirmed. Scratch (Scrt) is a member of the snail c2h2-type zinc- finger protein family of transcription factors and contains five c2h2 zinc finger motifs. It binds the E-box motif. Scratch is a transcriptional

Product Information Sheet - CTIR

site is present in every rat cell type, enabling immediate use in a broad range of research applications for rat genetics. ZFNs are composed of an engineered zinc finger DNA binding domain fused to the

Product Information Sheet - CTIM

present in every mouse cell type, enabling immediate use in a broad range of research applications for mouse genetics. ZFNs are composed of an engineered zinc finger DNA binding domain fused to

Product Information Sheet - ZFNSLC35A1

chain of zinc finger proteins and a DNA-cleaving domain comprised of the nuclease domain of FokI. Each zinc finger DNA binding protein recognizes a 3 base pair target. By combining 4-6 zinc finger proteins

An Application of Zinc Finger Nuclease Technology to Create Knock-in and Knock-out Cell Lines

’s Medium (Sigma D5671) containing 10% v/v fetal calf serum (Sigma F4135), 1mM sodium pyruvate (Sigma 8636), and 2mM L-glutamine (Sigma G7513) (DMEM complete media). Zinc-Finger Nuclease Design and Nucleofection

Data Sheet - SAB4200302

tumor suppression, depending upon the context in which it binds. The YY1 protein contains four C2H2- type zinc-finger motifs with two specific domains that characterize its function as activator or repressor

Data Sheet - SAB4200701

directing a DNA double-strand break (DSB) at a desired genomic location. Similar to DSBs induced by zinc finger nucleases (ZFNs), the cell then activates endogenous DNA repair processes, either non-homologous

Data Sheet - SAB4200531

ZNF746 (zinc finger protein 746, also known as PARIS, parkin interacting substrate), is a 644 amino acid protein that contains a Kruppel-associated box (KRAB) at its N-terminal and a C2HC/C2H2 type zinc

Data Sheet - SAB4200530

ZNF746 (zinc finger protein 746, also known as PARIS, parkin interacting substrate), is a 644 amino acid protein that contains a Kruppel-associated box (KRAB) at its N-terminal and a C2HC/C2H2 type zinc

Data Sheet - SAB4200751

directing a DNA double-strand break (DSB) at a desired genomic location. Similar to DSBs induced by zinc finger nucleases (ZFNs), the cell then activates endogenous DNA repair processes, either non-homologous

Data Sheet - G8669

GATA binding factor-5) is a member of the GATA family of transcription factors and contains 2 GATA-type zinc fingers. GATA5 is required for endothelial endocardial cell differentiation.1 Reagent

(CRISPR) - Technical Bulletin

life-science/zinc-finger-nuclease-technology/zfn- references.htmlhttp://www.sigmaaldrich.com/life-science/zinc-finger-nuclease-technology/zfn-references.html http://www.sigmaaldrich.com/life-science/zinc-finger-nuclease-technology

Data Sheet - L9669

family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity

Data Sheet - L9794

family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity

Data Sheet - L9544

family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity

Bulletin - HGECKO2G

References Chen et al. "High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases." Nature methods 8.9 (2011): 753-755. Duan, Z., et al. "Lentiviral shRNA screen

Product Information Sheet - CTI1

efficiency in some cell types,1 representing an improvement of three to four orders of magnitude in efficiency over normal homologous recombination events.2,3 Zinc finger nucleases are composed of

Bulletin - HWGCRISPR

References Chen et al. "High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases." Nature methods 8.9 (2011): 753-755. Duan, Z., et al. "Lentiviral shRNA screen

Product Information Sheet - HKCRISPR

References Chen et al. "High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases." Nature methods 8.9 (2011): 753-755. Duan, Z., et al. "Lentiviral shRNA screen

Product Information Sheet - I3411

lentiviral delivery. Key applications for transient gene expression have been the delivery of zinc finger nucleases (ZFNs) for genome editing (Lombardo, et al., 2007; Provasi, et al., 2012) and Cre protein

Data Sheet - SAB4200344

member of an RNA polymerase complex. SMYD3 contains a SET domain, which is critical for the methylation of histone H3 at Lys4, and a MYND-type zinc-finger domain, which is common to developmental proteins

Data Sheet - SAB1300002

retinoblastoma protein- interacting zinc finger gene RIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs

zinc finger CCCH-type containing 10