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zinc finger CCCH-type containing 12A
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Showing 1-28 of 28 results for "zinc finger CCCH-type containing 12A" within Papers
Fahu He et al.
Protein science : a publication of the Protein Society, 18(1), 80-91 (2009-01-30)
The muscleblind-like (MBNL) proteins 1, 2, and 3, which contain four CCCH zinc finger motifs (ZF1-4), are involved in the differentiation of muscle inclusion by controlling the splicing patterns of several pre-mRNAs. Especially, MBNL1 plays a crucial role in myotonic
Jordan D Pritts et al.
Biochemistry, 59(8), 970-982 (2020-02-07)
Cleavage and polyadenylation specificity factor 30 (CPSF30) is a "zinc finger" protein that plays a crucial role in the transition of pre-mRNA to RNA. CPSF30 contains five conserved CCCH domains and a CCHC "zinc knuckle" domain. CPSF30 activity is critical
Ling Liu et al.
The Biochemical journal, 451(1), 55-60 (2013-01-31)
Endothelial activation characterized by the expression of multiple chemokines and adhesive molecules is a critical initial step of vascular inflammation, which results in recruitment of leucocytes into the sub-endothelial layer of the vascular wall and triggers vascular inflammatory diseases such
Han Chiu et al.
Journal of virology, 96(1), e0166521-e0166521 (2021-10-14)
Zinc-finger protein 36, CCCH type-like 1 (ZFP36L1), containing tandem CCCH-type zinc-finger motifs with an RNA-binding property, plays an important role in cellular RNA metabolism mainly by RNA decay pathways. Recently, we demonstrated that human ZFP36L1 has potent antiviral activity against
Ruth S Phillips et al.
The Journal of biological chemistry, 277(13), 11606-11613 (2002-01-18)
Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger proteins can bind directly to certain types of AU-rich elements (AREs) in mRNA. Experiments in TTP-deficient mice have shown that TTP is involved in the physiological destabilization of at
Hiroshi Hamada et al.
International journal of oncology, 55(4), 896-904 (2019-08-23)
Human promyelocytic HL‑60 cells can be differentiated into macrophage‑like cells by treatment with 12‑O‑tetra decanoylphorbol‑13‑acetate (TPA). Certain 5' upstream regions of the zinc finger protein (ZNF)‑encoding genes contain duplicated GGAA motifs, which are frequently found in the TPA‑responding gene promoter
Rong Jiang et al.
Toxicology letters, 307, 26-40 (2019-03-04)
The epithelial to mesenchymal transition (EMT) contributes to fibrosis during silicosis. Zinc finger CCCH-type containing 4 protein (ZC3H4) is a novel CCCH-type zinc finger protein that activates inflammation in pulmonary macrophages during silicosis. However, whether ZC3H4 is involved in EMT
Seth Kelly et al.
RNA biology, 9(5), 555-562 (2012-05-23)
Polyadenosine RNA binding proteins (Pabs) play critical roles in regulating the polyadenylation, nuclear export, stability, and translation of cellular RNAs. Although most Pabs are ubiquitously expressed and are thought to play general roles in post-transcriptional regulation, mutations in genes encoding
John L Goodier et al.
PLoS genetics, 19(7), e1010795-e1010795 (2023-07-05)
Retrotransposons have generated about half of the human genome and LINE-1s (L1s) are the only autonomously active retrotransposons. The cell has evolved an arsenal of defense mechanisms to protect against retrotransposition with factors we are only beginning to understand. In
Silvia B V Ramos
The Journal of biological chemistry, 287(16), 13116-13127 (2012-03-01)
The zinc finger protein 36-like 2, Zfp36l2, has been implicated in female mouse infertility, because an amino-terminal truncation mutation (ΔN-Zfp36l2) leads to two-cell stage arrest of embryos derived from the homozygous mutant female gamete. Zfp36l2 is a member of the
A Velyvis et al.
The Journal of biological chemistry, 276(7), 4932-4939 (2000-11-18)
PINCH is a recently identified adaptor protein that comprises an array of five LIM domains. PINCH functions through LIM-mediated protein-protein interactions that are involved in cell adhesion, growth, and differentiation. The LIM1 domain of PINCH interacts with integrin-linked kinase (ILK)
Jinbo Huang et al.
Protein & cell, 10(4), 272-284 (2018-03-16)
N6-methyladenosine (m6A), a ubiquitous RNA modification, is installed by METTL3-METTL14 complex. The structure of the heterodimeric complex between the methyltransferase domains (MTDs) of METTL3 and METTL14 has been previously determined. However, the MTDs alone possess no enzymatic activity. Here we
Wi S Lai et al.
The Journal of biological chemistry, 277(11), 9606-9613 (2002-01-10)
Tristetraprolin (TTP), the prototype of a small family of CCCH tandem zinc finger (TZF) domain proteins, is a physiological stimulator of instability of the mRNAs encoding tumor necrosis factor-alpha and granulocyte/macrophage colony-stimulating factor in certain cell types. TTP stimulates mRNA
Perry J Blackshear et al.
The Journal of biological chemistry, 278(22), 19947-19955 (2003-03-18)
Tristetraprolin (TTP) and its two known mammalian family members are tandem CCCH zinc finger proteins that can bind to AU-rich elements (AREs) in cellular mRNAs and destabilize those transcripts, apparently by initiating their deadenylation. Previous studies have shown that the
Xiaoyong Chen et al.
Virus research, 319, 198876-198876 (2022-07-26)
Influenza a virus exploits host machinery to benefit its replication in host cells. Knowledge of host factors reveals the complicated interaction and provides potential targets for antiviral treatment. Here, instead of the traditional proteomic analysis, we employed a 4D label
Tatsuya Kozaki et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(10), 2681-2686 (2017-02-19)
The innate immune system senses RNA viruses by pattern recognition receptors (PRRs) and protects the host from virus infection. PRRs mediate the production of immune modulatory factors and direct the elimination of RNA viruses. Here, we show a unique PRR
Shady Younis et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(16), E3808-E3816 (2018-04-04)
The zinc finger CCCH-type containing 11A (ZC3H11A) gene encodes a well-conserved zinc finger protein that may function in mRNA export as it has been shown to associate with the transcription export (TREX) complex in proteomic screens. Here, we report that
Matteo Audano et al.
The Journal of cell biology, 220(3) (2021-02-11)
The commitment of mesenchymal stem cells to preadipocytes is stimulated by hormonal induction. Preadipocytes induced to differentiate repress protein synthesis, remodel their cytoskeleton, and increase mitochondrial function to support anabolic pathways. These changes enable differentiation into mature adipocytes. Our understanding
Chuxiao Zhang et al.
Carcinogenesis, 40(3), 474-486 (2018-10-30)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Genomic copy number deletion at chromosome 14q31.1-32.13 was frequently observed in HCC; however, the relevant functional target(s) at that locus is not well determined. Here, we performed integrative
Silvia B V Ramos et al.
Development (Cambridge, England), 131(19), 4883-4893 (2004-09-03)
The CCCH tandem zinc finger protein, Zfp36l2, like its better-known relative tristetraprolin (TTP), can decrease the stability of AU-rich element-containing transcripts in cell transfection studies; however, its physiological importance is unknown. We disrupted Zfp36l2 in mice, resulting in decreased expression
Jessica A Hurt et al.
The Journal of cell biology, 185(2), 265-277 (2009-04-15)
Coupling of messenger RNA (mRNA) nuclear export with prior processing steps aids in the fidelity and efficiency of mRNA transport to the cytoplasm. In this study, we show that the processes of export and polyadenylation are coupled via the Drosophila
Clare Gooding et al.
Nucleic acids research, 41(9), 4765-4782 (2013-03-21)
Exon 3 of the rat α-tropomyosin (Tpm1) gene is repressed in smooth muscle cells, allowing inclusion of the mutually exclusive partner exon 2. Two key types of elements affect repression of exon 3 splicing: binding sites for polypyrimidine tract-binding protein
Clare Gooding et al.
Nucleic acids research, 41(9), 4765-4782 (2013-03-21)
Exon 3 of the rat α-tropomyosin (Tpm1) gene is repressed in smooth muscle cells, allowing inclusion of the mutually exclusive partner exon 2. Two key types of elements affect repression of exon 3 splicing: binding sites for polypyrimidine tract-binding protein
Jian Liang et al.
The Journal of biological chemistry, 284(43), 29383-29390 (2009-09-10)
Tristetraprolin (TTP) is a CCCH zinc finger-containing protein that destabilizes mRNA by binding to an AU-rich element. Mice deficient in TTP develop a severe inflammatory syndrome mainly because of overproduction of tumor necrosis factor alpha. We report here that TTP
P J Blackshear
Biochemical Society transactions, 30(Pt 6), 945-952 (2002-11-21)
The tristetraprolin (TTP) family of CCCH tandem zinc-finger proteins is composed of three known members in mammals, with a fourth member recently identified in frogs and fish. Although TTP was first cloned more than 10 years ago as a growth
Matteo Audano et al.
EMBO reports, 19(4) (2018-03-07)
Mitochondria are the energy-generating hubs of the cell. In spite of considerable advances, our understanding of the factors that regulate the molecular circuits that govern mitochondrial function remains incomplete. Using a genome-wide functional screen, we identify the poorly characterized protein
Jixiao Niu et al.
The EMBO journal, 32(24), 3206-3219 (2013-11-26)
DNA damage-induced activation of the transcription factor NF-κB plays an important role in the cellular response to genotoxic stress. However, uncontrolled NF-κB activation upon DNA damage may lead to deleterious consequences. Although the mechanisms mediating genotoxic NF-κB activation have been
Thierry J Horner et al.
Molecular and cellular biology, 29(8), 1999-2010 (2009-02-04)
Polo-like protein kinase 3 (Plk3) has been proposed to regulate entry into S phase and promote apoptosis in response to oxidative stress. Its mRNA contains three AU-rich elements (AREs) in its 3' untranslated region (3'-UTR) that can contribute to the
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