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  • Widespread expression of γ-glutamyl cyclotransferase suggests it is not a general tumor marker.

Widespread expression of γ-glutamyl cyclotransferase suggests it is not a general tumor marker.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society (2011-12-30)
Tomonari Amano, Yoshinobu Eishi, Tetsuo Yamada, Keisuke Uchida, Kana Minegishi, Tomoki Tamura, Daisuke Kobayashi, Kawachi Hiroshi, Takashige Suzuki, Philip G Board
ABSTRACT

γ-Glutamyl cyclotransferase (GGCT) contributes to the γ-glutamyl cycle that regulates glutathione metabolism. Although GGCT has been implicated in several studies as a possible cancer marker, little is known about its distribution in cells and tissues. The authors investigated GGCT expression in normal tissues and tumors using Western blots and immunohistochemistry with a novel anti-GGCT monoclonal antibody. GGCT was detected in most organs and was mainly found in epithelial cells. Although the intracellular distribution was mainly cytoplasmic, in some situations, nuclear staining was strong. A significant increase in the expression of GGCT was found in tumors of the lung, esophagus, stomach, bile duct, and uterine cervix. In contrast, there was a significant decrease in expression in renal and urothelial tumors. These results suggest that GGCT may be a biomarker of tumors in a limited range of organs.