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  • Sensitive sugar detection using 4-aminophenylboronic acid modified graphene.

Sensitive sugar detection using 4-aminophenylboronic acid modified graphene.

Biosensors & bioelectronics (2013-07-25)
Qi Wang, Izabela Kaminska, Joanna Niedziolka-Jonsson, Marcin Opallo, Musen Li, Rabah Boukherroub, Sabine Szunerits
ABSTRACT

A sensitive electrochemical active interface for sugar sensing based on the specific boronic acid-diol binding was established. The sensing matrix was formed by stirring a suspension of graphene oxide (GO) with 4-aminophenylboronic acid (APBA). The resulting composite consists of a water insoluble precipitate of reduced graphene oxide (rGO) with APBA incorporated into the rGO matrix. Differential pulse voltammetry (DPV) on glassy carbon electrodes modified with rGO/APBA was used for the detection of fructose, mannose and glucose. The fabricated sensor exhibited a wide linear range with detection limits of 100 nM for fructose, and around 800 nM for mannose and glucose.

MATERIALS
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Product Description

Sigma-Aldrich
4-Aminophenylboronic acid hydrochloride, 95%