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  • Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line.

Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line.

Brain research (1994-07-25)
J B Davis, P Maher
ABSTRACT

A neuronal cell line, HT-22, is sensitive to glutamate cytotoxicity via a non-receptor mediated oxidative pathway. 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C, blocks this glutamate-induced cell death. Down-regulation of protein kinase C eliminates the protection against glutamate cytotoxicity afforded by TPA. The data suggest that protein kinase C activation blocks an early step in the cytotoxic pathway.

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HT-22 Mouse Hippocampal Neuronal Cell Line, HT-22 mouse neuronal cell line is a valuable cell model for studies of glutamate-induced toxicity in neuronal cells.