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Antidiabetic effects of corosolic acid in KK-Ay diabetic mice.

Biological & pharmaceutical bulletin (2006-03-02)
Toshihiro Miura, Naoya Ueda, Koutaro Yamada, Mitsuo Fukushima, Torao Ishida, Tetsuo Kaneko, Futoshi Matsuyama, Yutaka Seino
ABSTRACT

The antidiabetic effects of corosolic acid (CA) were investigated in KK-Ay mice, an animal model of type 2 diabetes. CA (2 mg/kg body weight) reduced the blood glucose levels of KK-Ay mice 4 h after a single oral dose. CA (2 mg/kg) reduced the blood glucose levels in KK-Ay mice 2 weeks after a single oral dose and also significantly lowered plasma insulin levels were in KK-Ay mice under similar conditions. CA-treated KK-Ay mouse blood glucose significantly decreased in an insulin tolerance test. These results support the hypothesis that CA improves glucose metabolism by reducing insulin resistance. Therefore CA may be useful for the treatment of type 2 diabetes.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Corosolic acid from Lagerstroemia speciosa, ≥98% (HPLC)