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  • Design, synthesis and identification of novel colchicine-derived immunosuppressant.

Design, synthesis and identification of novel colchicine-derived immunosuppressant.

Bioorganic & medicinal chemistry letters (2009-06-09)
Dong-Jo Chang, Eun-Young Yoon, Geon-Bong Lee, Soon-Ok Kim, Wan-Joo Kim, Young-Myeong Kim, Jong-Wha Jung, Hongchan An, Young-Ger Suh
ABSTRACT

Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A.

MATERIALS
Product Number
Brand
Product Description

Supelco
Cyclosporin A, VETRANAL®, analytical standard
Sigma-Aldrich
Cyclosporin A, from Tolypocladium inflatum, BioReagent, for molecular biology, ≥95%
Sigma-Aldrich
Cyclosporin A, from Tolypocladium inflatum, ≥95% (HPLC), solid
Sigma-Aldrich
Cyclosporin A, 97.0-101.5% (on dried basis)
Sigma-Aldrich
Colchicine, BioReagent, suitable for plant cell culture, ≥95% (HPLC)
Sigma-Aldrich
Colchicine, ≥95% (HPLC), powder