Skip to Content
MilliporeSigma

The Japanese toxicogenomics project: application of toxicogenomics.

Molecular nutrition & food research (2009-12-31)
Takeki Uehara, Atsushi Ono, Toshiyuki Maruyama, Ikuo Kato, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani
ABSTRACT

Biotechnology advances have provided novel methods for the risk assessment of chemicals. The application of microarray technologies to toxicology, known as toxicogenomics, is becoming an accepted approach for identifying chemicals with potential safety problems. Gene expression profiling is expected to identify the mechanisms that underlie the potential toxicity of chemicals. This technology has also been applied to identify biomarkers of toxicity to predict potential hazardous chemicals. Ultimately, toxicogenomics is expected to aid in risk assessment. The following discussion explores potential applications and features of the Japanese Toxicogenomics Project.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Ethanol, purum, absolute ethanol, denaturated with 2% 2-butanone, A15 MEK1, ≥99.8% (based on denaturant-free substance)
Sigma-Aldrich
Ethanol, purum, fine spirit, denaturated with 4.8% methanol, F25 METHYL1, ~96% (based on denaturant-free substance)
Sigma-Aldrich
Ethanol, puriss. p.a., absolute, ≥99.8% (GC)
Sigma-Aldrich
(S)-(+)-6-Methoxy-α-methyl-2-naphthaleneacetic acid, 98%
Sigma-Aldrich
Caffeine, anhydrous, tested according to Ph. Eur.
Sigma-Aldrich
Ciprofloxacin, ≥98% (HPLC)
Supelco
Naproxen, VETRANAL®, analytical standard
Sigma-Aldrich
N-Phenylanthranilic acid, 98%
Sigma-Aldrich
Allyl alcohol, ≥99%
Sigma-Aldrich
Allyl alcohol, ≥98.5%
Sigma-Aldrich
Caffeine, anhydrous, 99%, FCC, FG
Sigma-Aldrich
Caffeine, powder, ReagentPlus®
Sigma-Aldrich
Diazepam
Sigma-Aldrich
L-Ethionine, ≥99% (TLC)
Sigma-Aldrich
Crotaline
Sigma-Aldrich
Ketoconazole, 99.0-101.0% (EP, titration)
Sigma-Aldrich
D-Penicillamine, 98-101%
Sigma-Aldrich
N-Nitrosodiethylamine, ISOPAC®
Sigma-Aldrich
Caffeine, BioXtra
Sigma-Aldrich
Colchicine, ≥95% (HPLC), powder
Sigma-Aldrich
Captopril, meets USP testing specifications
Sigma-Aldrich
Captopril, ≥98% (HPLC), powder
Sigma-Aldrich
Glyburide, meets USP testing specifications
Sigma-Aldrich
5,5-Diphenylhydantoin, ≥98%
Sigma-Aldrich
Aspirin, meets USP testing specifications
Sigma-Aldrich
6-Propyl-2-thiouracil, enzyme inhibitor
Sigma-Aldrich
N-(2-Mercaptopropionyl)glycine
Supelco
Tolbutamide, analytical standard
Supelco
Ethanol standards 10% (v/v), 10 % (v/v) in H2O, analytical standard
Sigma-Aldrich
Phenobarbital