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  • Dual-emissive quantum dots for multispectral intraoperative fluorescence imaging.

Dual-emissive quantum dots for multispectral intraoperative fluorescence imaging.

Biomaterials (2010-07-14)
Patrick T K Chin, Tessa Buckle, Arantxa Aguirre de Miguel, Stefan C J Meskers, René A J Janssen, Fijs W B van Leeuwen
ABSTRACT

Fluorescence molecular imaging is rapidly increasing its popularity in image guided surgery applications. To help develop its full surgical potential it remains a challenge to generate dual-emissive imaging agents that allow for combined visible assessment and sensitive camera based imaging. To this end, we now describe multispectral InP/ZnS quantum dots (QDs) that exhibit a bright visible green/yellow exciton emission combined with a long-lived far red defect emission. The intensity of the latter emission was enhanced by X-ray irradiation and allows for: 1) inverted QD density dependent defect emission intensity, showing improved efficacies at lower QD densities, and 2) detection without direct illumination and interference from autofluorescence.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
InP/ZnS quantum dots, stabilized with oleylamine ligands, fluorescence λem 590 nm, 5 mg/mL in toluene
Sigma-Aldrich
InP/ZnS quantum dots, stabilized with oleylamine ligands, fluorescence λem 560 nm, 5 mg/mL in toluene
Sigma-Aldrich
InP/ZnS quantum dots, stabilized with oleylamine ligands, fluorescence λem 620 nm, 5 mg/mL in toluene
Sigma-Aldrich
InP/ZnS quantum dots, stabilized with oleylamine ligands, fluorescence λem 530 nm, 5 mg/mL in toluene
Sigma-Aldrich
InP/ZnS quantum dots, stabilized with oleylamine ligands, fluorescence λem 650 nm, 5 mg/mL in toluene