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  • Maternal and fetal toxicity of N-methylmorpholine by oral administration in rats.

Maternal and fetal toxicity of N-methylmorpholine by oral administration in rats.

Teratogenesis, carcinogenesis, and mutagenesis (1999-12-10)
K Sitarek
ABSTRACT

N-methylmorpholine, which is used as a catalyst in polyurethane foams producing, in solvents, stabilizing agents, and corrosion inhibitors, was administered to female rats by gavage at 100, 200, 600, and 900 mg/kg during organogenesis. It did not exhibit selective toxicity toward the developing conceptus. This compound administered to pregnant females was fetotoxic and teratogenic in the presence of maternal toxicity. N-methylmorpholine induced anophthalmia, internal hydrocephalus, and hydronephrosis but only at one dose which was also maternotoxic. Teratogenesis Carcinog. Mutagen. 19:369-376, 1999.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
4-Methylmorpholine, purum, ≥98.0% (GC)
Sigma-Aldrich
4-Methylmorpholine, BioXtra, suitable for protein sequencing, ≥99.5% (GC)
Sigma-Aldrich
4-Methylmorpholine, purified by redistillation, ≥99.5%
Sigma-Aldrich
4-Methylmorpholine, ReagentPlus®, 99%